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Query: UMLS:C0242339 (dyslipidemia)
 13,927 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We sought to determine whether lipid levels in black patients with type II diabetes with and without hypertension differ from those in white patients. Lipid levels were screened in 207 blacks and 103 whites with type II diabetes visiting a weekly diabetes clinic in a southeastern US regional community hospital. Levels of high- and low-density lipoprotein cholesterol were significantly higher in blacks than in whites: 1.30 +/- 0.34 vs 1.05 +/- 0.27 mmol/L (P < .001) and 3.73 +/- 1.23 vs 3.31 +/- 1.11 mmol/L (P = .01), respectively; triglycerides were higher in whites: 3.90 +/- 4.58 vs 1.96 +/- 1.51 mmol/L (P < .001). White hypertensive women had higher cholesterol and triglyceride levels and lower high-density lipoprotein cholesterol levels than white normotensive women (adjusted for age); no differences existed between black hypertensive and normotensive women when we adjusted for age. Seventy-two percent of blacks and 85% of whites had an abnormal lipid value (P = .01). Phenotype distribution was significantly different: 58.7% of blacks with abnormal lipids were in phenotype IIA (elevated low-density lipoprotein cholesterol with normal triglycerides), and 16.7% in IVA and B combined (elevated triglycerides) (P < .001), whereas whites were 17.0% and 52.3%, respectively. Blacks demonstrated a different dyslipidemia compared to whites. The contrasting effect of hypertension on triglyceride and cholesterol levels in white women with diabetes compared to black women suggests a racial difference in the relationship between hypertension and lipids among patients with diabetes.
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PMID:Lipid level differences and hypertension effect in blacks and whites with type II diabetes. 816 40

The type of dyslipidemia in patients with peripheral arterial disease (PAD) is still ill defined. PAD patients often show elevated triglycerides and reduced HDL-cholesterol, two lipid abnormalities usually accompanied by decreased LDL size in the "atherogenic lipoprotein phenotype" (ALP). We investigated (1) whether PAD patients have lower LDL size, (2) altered LDL subclass distribution and (3) the prevalence of ALP. We measured plasma lipids and LDL size and subclasses by gradient gel electrophoresis in 31 adults with intermittent claudication and 31 age-BMI-matched controls. Patients had higher prevalence of hypertension (p=.0132), smoking (p<.0020) and diabetes (p=.0024), with lower HDL-cholesterol (p<.0001) and increased triglycerides (p=.0057); LDL size was smaller (p<.0001), with decreased larger subclasses (LDL-I, p<.0001; LDL-IIA, p=.0068) and increased smaller particles (LDL-IIIA, p<.0001; LDL-IIIB, p=.0013; LDL-IVA, p=.0029; LDL-IVB, p<.0001). The presence of PAD was independently associated with smoking (OR 7.2, p=.0099), hypertension (OR 6.5, p=.0362), diabetes (OR 5.5, p=.0450) and elevated small, dense LDL (OR 6.7, p=.0497). The concomitant presence of high triglycerides, low HDL-cholesterol and elevated small, dense LDL in patients was 26% (versus 0% controls, p=.0024). ALP seems to characterize PAD dyslipidemia, but prospective studies are needed to test whether this lipoprotein phenotype may represent a risk factor too.
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PMID:Atherogenic lipoprotein phenotype and LDL size and subclasses in patients with peripheral arterial disease. 1748 96

Metabolic syndrome characterized by insulin resistance and obesity is accompanied by severe lipid metabolism perturbations and chronic low-grade inflammation. However, many unresolved questions remained regarding the regulation that underlie dyslipidemia, particularly the regulation of the metabolic cascade (synthesis and release) leading to eicosanoid precursors release. This study was undertaken to investigate the regulation of desaturases/elongases and phospholipases A(2) during the establishment of metabolic syndrome. Our results showed that delta-6 desaturase as well as elongase-6 expressions were upregulated in 3-month-old Zucker fatty rats as compared to lean littermates, independently of SREBP-1c activation. We also demonstrated for the first time an increase of liver group VII phospholipase A(2) gene expression in the obese animals together with a strong specific inhibition of type IVA and VIA phospholipases A(2). These results suggest that the regulation of unsaturated fatty acids biosynthesis and signalling cascade could contribute to the development of liver lipid dysregulation related to metabolic syndrome and may be considered as new potential targets in such pathological conditions.
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PMID:The metabolic cascade leading to eicosanoid precursors--desaturases, elongases, and phospholipases A2--is altered in Zucker fatty rats. 2117 52