Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0242339 (dyslipidemia)
 13,927 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Chronic diseases of gall-bladder are found in 3-5% of pregnancies. Lipid metabolism also undergoes essential changes. The aim of our investigation was to study the peculiarities of lipid metabolism in pregnant patients with chronic cholecystitis. 33 pregnant patients with chronic cholecystitis have been investigated. The duration of pregnancy was 36,8+/-0,4 weeks. Control group consisted of 30 practically healthy pregnant patients in the third trimester. All parameters of lipid metabolism have been determined by biochemical analysis. The parameters of lipid metabolism became significantly impaired in patients with chronic cholecystitis in comparison with controls. They revealed significant both direct and inverse correlations with sex hormones. Obtained results point the organism adaptive mechanisms expressed in the increase of antiatherogenic fraction of total cholesterol; also the influence of sex hormones. In pregnancy, physiological dyslipidemia increases, which is metabolic basis for the development of "prestage" of gall-stone--cholestasis of gall-bladder.
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PMID:[Peculiarities of lipid metabolism in pregnant patients with chronic cholecystitis]. 1726 78

The aim of investigation was to study the influence of obesity on the development of cholelithiasis and chronic cholecystitis in pregnant patients. The type of investigation was case-control study. Inclusion criteria were cholelithiasis and chronic cholecystitis. Exclusion criteria were severe maternal diseases (preeclampsy, eclampsy, haemorrhagia) during pregnancy and in past. The main group consisted of 30 cases. For each case 2-4 pregnant patients served as control. Obesity was assessed by body mass index (BMI), and visceral obesity before pregnancy--by waist circumference (WC, criterium of WC>88 cm). In main group obesity by BMI was observed in 19 cases (63.3%), in control group--in 18 subjects (20.0%); therefore statistically significant odds ratio was OR=6.90 (95%CI--2.80/17.07). In main group obesity by WC was observed in 12 cases (40.0%), in control group--in 18 subjects [20.0%; OR=2.67 (95%CI--1.09/6.52)]. Increment of BMI during pregnancy in main group was 7.5+/-1.6 kg/m2; in control group--4.5+/-1.6 kg/m2 (p<0.001). As for WC increment during pregnancy, in main group it was 23.2+/-1.9 cm; and in control--18.1+/-3.8 cm (p<0.001). BMI, WC values and their increment are significantly increased in patients with diseases of gall bladder during pregnancy. Physiological dyslipidemia during pregnancy is more aggravated, but in patients with diseases of gall bladder lipid characteristics are even greater deteriorated.
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PMID:[Relationship of cholelithiasis with obesity in pregnancy]. 1766 May 99

We herein report an 87-year-old woman who was taking clonazepam at 1.5 mg/day. She was hospitalized with an old cerebral infarction complicated with symptomatic epilepsy, dementia, dyslipidemia, and chronic cholecystitis. Electrocardiogram revealed severe bradycardia at 31 beats/min. The bradycardia disappeared on day 3 after clonazepam withdrawal, although the serum clonazepam level had been within normal limits. She was diagnosed with clonazepam-associated bradycardia, which was likely related to the potential calcium channel-blocking properties of clonazepam. Because of age-related pharmacokinetic and pharmacodynamic changes, the adverse effects of clonazepam should be considered, especially in disabled elderly individuals with multiple comorbidities.
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PMID:Clonazepam-associated Bradycardia in a Disabled Elderly Woman with Multiple Complications. 2879 60