Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0241981 (loss of balance)
 452 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Suriclone selectively displaces benzodiazepines from their binding sites but is structurally unrelated to benzodiazepines. Neurologic effects of suriclone were compared to those of diazepam in 54 subjects in a sequential, double-blind, single dose, randomized study (placebo; diazepam 10 mg; suriclone 0.2, 0.4, 0.6, or 0.8 mg). Data were collected on-line by microcomputer. Suriclone 0.2 mg did not differ from placebo. Suriclone 0.4 mg and 0.6 mg did not differ from diazepam 10 mg. Suriclone 0.8 mg caused significantly more decrement than diazepam 10 mg (p less than 0.05) in manual tracking, force platform stability, and Heath rail walking and in total severity of symptoms. Suriclone 0.8 mg caused nausea (p = 0.02), clumsiness (p = 0.02), and loss of balance (p = 0.01) more frequently than diazepam 10 mg. Suriclone 0.8 mg produced symptoms and signs qualitatively and quantitatively different from diazepam 10 mg, such as vomiting, unusual ocular movement effects, and difficulty walking. Possibly the differences in CNS drug binding for anxiolytics are associated with clinical differences in toxicity.
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PMID:Comparative neurologic effects of diazepam and suriclone, a cyclopyrrolone anxiolytic. 289 78

The purpose of this study was to determine whether or not employed women, during pregnancy or the immediate postpartum period, differ from nonpregnant employed women in reaction time and upper extremity strength. Differences in reaction time, strength, and/or physical work capacity during pregnancy could have implications for maternal and fetal safety, and for job assignment, tool design, and work process design for expectant mothers. Balance is affected by changes in weight, body contour, and center of gravity shift (National Safety News 1979; 119:77-80). Awkwardness, fatigue, and tendency toward loss of balance could become critical, especially when rapid movement or reaction is required for safety or task performance.
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PMID:Reaction time and strength in pregnant and nonpregnant employed women. 337 51