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Query: UMLS:C0241981 (loss of balance)
 452 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A neurological disease of cattle (maldronksiekte), occurring in a localized area of the Northern Transvaal, was experimentally reproduced by feeding Solanum kwebense plants to cattle. The disease is characterized by temporary loss of balance and transient epileptiform seizures precipitated by a variety of stimuli, such as exercise, handling (dipping, loading, etc) and fright. When not disturbed, most affected animals appear to be completely normal. The most conspicuous histopathological lesion is a neuronopathy manifested by vacuolar degeneration and eventual necrosis of neurones, particularly of the Purkinje cells in the cerebellum. An atrophy of the cerebellar cortex is seen grossly. The history, clinical signs and experimental reproduction of the disease, as well as the pathology of 4 experimental and 18 natural cases, are described.
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PMID:Maldronksiekte in cattle: a neuronopathy caused by Solanum kwebense N.E. Br. 101 91

The structured clinical history is the most sensitive test for diagnosing vertigo. Its diagnostic effectiveness on the first visit was analyzed and key signs and symptoms with high predictive value for common causes of vertigo were identified. One hundred outpatients who complained of dizziness or loss of balance were evaluated using a structured clinical interview. Each questionnaire was examined independently by three blinded investigators, who assigned a diagnosis and identified the elements of the history that figured most prominently in the diagnosis. The gold standard was defined as independent selection of the same diagnostic category by all three investigators. A first-visit diagnosis was obtained in 40% of patients (95% confidence interval 30-50%): 38% women and 42% men. Causes included benign positional paroxysmal vertigo (BPPV, 13 patients), headache-associated vertigo (9), Meniere disease (7), cervical vertigo (3), psychiatric dizziness (2), post-traumatic vertigo (2), vertebro-basilar transient ischemic attack (1), vestibular neuritis (1), convulsive seizure (1), and presyncope (1). The best predictors of BPPV were the precipitating mechanism (specificity [SP] 100%), positional nystagmus (sensitivity [SE] 90%, SP 63%), and the Dix-Hallpike test (SE 82%, SP 71%). Elements predictive of headache-associated vertigo were duration of the attack (minutes) and a personal history of headache (both, SP 100%). Other predictors were facial hypoesthesia (SE 92%, SP 47%) and associated neurological disease (SE 82%, SP 58%).
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PMID:[Diagnosis of common causes of vertigo using a structured clinical history]. 1079 28