Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0241981 (
loss of balance
)
452
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Finely tuned excitation-inhibition balance is essential for proper brain function, and
loss of balance
resulting from reduced synaptic inhibition is associated with neurological disorders. Savardi and colleagues have discovered a novel inhibitor of a cation-chloride transporter that is required for synaptic inhibition, and which restores behaviors associated with
Down syndrome
(DS) and autism spectrum disorder (ASD).
...
PMID:A Novel Small Molecule Targets NKCC1 To Restore Synaptic Inhibition. 3309 85
