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Pivot Concepts:
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Target Concepts:
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Query: UMLS:C0241981 (
loss of balance
)
452
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The Pogo (pogo/pogo) mouse is a naturally occurring neurological mutant from a Korean wild-type mouse characterized by
loss of balance
and motor coordination due to dysfunction of the cerebellum. The Pogo mutation is believed to be an allele of P/Q-type
calcium channel
mutants such as tottering, leaner, and rolling mouse Nagoya. These mutants have been served as mouse models for a group of neurodegenerative diseases. The overall aim of this minireview is to summarize our current understanding of the ataxic Pogo mouse. To address this issue, we first describe the discovery of Pogo mouse and its morphological and behavioral defects. Then, we focus on the abnormal expression of several molecules in the Pogo cerebellum, including tyrosine hydroxylase, glutamate, corticotrophin-releasing factor, and 5-hydroxytryptamine. Much of this review is concerned with the functional implications of these ectopic molecules in the Pogo cerebellum.
...
PMID:Pogo: a novel spontaneous ataxic mutant mouse. 1922 8
