Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0240066 (iron deficiency)
 7,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The subjects for this study were 24 female, well-trained distance runners and 41 sedentary, female university students. On the basis of haematological measurements, the subjects were divided into four groups: a group with iron deficiency, non-anemic (normal haemoglobin and red cell count but serum ferritin less than 20 micrograms degrees 1-1) runners (IDR, n = 11), a group of runners with normal iron status (NR, n = 13), a group of sedentary women with normal iron status (NC, n = 26) and a group of iron deficient, non-anemic sedentary subjects (IDC, n = 15). Maximal oxygen uptake (VO2max) and lactate thresholds were determined during incremental bicycle ergometer exercise testing and on separate occasions the ratings of perceived exertion (RPE) were assessed at 25, 50, 75 and 90% VO2max using Borg's scale. There were no differences in the relationship between RPE and work load groups of runners or sedentary subjects with normal and deficient iron status. Iron deficiency did not affect VO2max and lactate thresholds. However, low body iron stores (serum ferritin level below 20 micrograms degrees 1-1) without overt anemia was associated with increased venous blood lactate concentration after maximal exercise load. This study demonstrated that physical work capacity and RPE were not affected by iron deficiency without anemia either in trained or untrained women.
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PMID:The relationship between iron status and perceived exertion in trained and untrained women. 812 89

In soybean [Glycine max (L.) Merr.], iron deficiency results in interveinal chlorosis and decreased photosynthetic capacity, leading to stunting and yield loss. In this study, gene expression analyses investigated the role of soybean replication protein A (RPA) subunits during iron stress. Nine RPA homologs were significantly differentially expressed in response to iron stress in the near isogenic lines (NILs) Clark (iron efficient) and Isoclark (iron inefficient). RPA homologs exhibited opposing expression patterns in the two NILs, with RPA expression significantly repressed during iron deficiency in Clark but induced in Isoclark. We used virus induced gene silencing (VIGS) to repress GmRPA3 expression in the iron inefficient line Isoclark and mirror expression in Clark. GmRPA3-silenced plants had improved IDC symptoms and chlorophyll content under iron deficient conditions and also displayed stunted growth regardless of iron availability. RNA-Seq comparing gene expression between GmRPA3-silenced and empty vector plants revealed massive transcriptional reprogramming with differential expression of genes associated with defense, immunity, aging, death, protein modification, protein synthesis, photosynthesis and iron uptake and transport genes. Our findings suggest the iron efficient genotype Clark is able to induce energy controlling pathways, possibly regulated by SnRK1/TOR, to promote nutrient recycling and stress responses in iron deficient conditions.
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PMID:Replication protein A subunit 3 and the iron efficiency response in soybean. 2374 35