Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0240066 (iron deficiency)
 7,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The relationship between iron status and capacity for IL-2 production by lymphocytes was assessed in 81 children from 6 mo to 3 yr of age selected at random from a population with low socioeconomic status, undergoing free systematic examination in four children's health centers in the Paris area. Iron deficiency was defined by the existence of at least two abnormal values among the three indicators of iron status: serum ferritin level less than or equal to 12 micrograms/L, transferrin saturation less than 12%, and erythrocyte protoporphyrin concentration greater than 3 micrograms/g hemoglobin. According to this definition, 53 children were classified as iron deficient and 28 as iron sufficient. No differences were observed between the iron-deficient and iron-sufficient groups in terms of the IL-2 concentration without stimulation by PHA. IL-2 production by lymphocytes stimulated with PHA, as well as the stimulation index (ratio of IL-2 concentration following stimulation by PHA to that of IL-2 concentration without stimulation by PHA) were significantly lower in iron-deficient children. The reduction in IL-2 production by activated lymphocytes observed in our study of iron-deficient children may be responsible for impairments in immunity found by other authors, particularly in cell-mediated immunity.
 ...
PMID:Interleukin 2 production in iron-deficient children. 137 84

To delineate the alterations of the immune function induced by iron deficiency male Sprague-Dawley rats were obtained at 3 weeks of age and fed an iron-deficient diet. By the end of the 3rd week on this diet the animals were anemic and ferropenic. A marked increase in the proliferative response of splenic lymphocytes at optimal doses of mitogen (PHA, Con A, and PWM) was observed. On the contrary, thymic lymphocytes showed a decreased proliferative response. Time-course experiments demonstrated significant alterations in these proliferative responses after only 1 week of iron deprivation, at a time when the level of hemoglobin was normal. Nutritional rehabilitation after 5 weeks of iron deprivation showed complete recovery of the response after 11/2 weeks on normal diet.
 ...
PMID:Effect of iron deficiency on the mitogen-induced proliferative response of rat lymphocytes. 714 18