Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0240066 (
iron deficiency
)
7,156
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Acyl carrier proteins (ACPs) are a group of small acidic proteins functioning as important cofactors in the
de novo
synthesis of fatty acids. In
Arabidopsis
, ACPs are encoded by a small gene family comprising five plastid members,
AtACP1
to
AtACP5
, and three mitochondrial members. The biological functions and the transcriptional responses to abiotic stresses of most AtACPs have yet to be elucidated. The present study extends previous findings and provides new knowledge on the function of ACPs by examining the responses of AtACP-encoding genes to several abiotic stresses and, in particular, the role of
AtACP5
in the adaptation to salt stress. Phylogenetic analysis showed that AtACP1, AtACP2, AtACP3, and AtACP5 can be classified into one group and separated from a group comprising AtACP4 and
ACP
homologs from related species. Quantitative RT-PCR analysis revealed that the expression of
AtACP1, AtACP2
, and
AtACP3
was induced by drought. Both
iron deficiency
and nitrogen starvation resulted in down-regulation of
AtACP4
. The most pronounced response was observed for
AtACP5
, the expression of which was dramatically decreased by salt stress. Knock-out of
AtACP5
showed increased sensitivity to NaCl stress, whereas transgenic lines overexpressing
AtACP5
displayed increased salt tolerance relative to the wild-type. Overexpression of
AtACP5
further led to an altered composition of fatty acids, mainly a decrease of oleic acid (C18:1) and an increase of palmitic acid (C16:0), and to a lower Na
+
/K
+
ratio when compared to the salt stressed wild-type. The comprehensive transcriptional information on the small plastid AtACP gene family in response to various abiotic stresses and the further investigation of the
AtACP5
indicate that
AtACP5
might be critical for salt tolerance through alterations of the composition of fatty acids and, subsequently, the Na
+
/K
+
ratio.
...
PMID:Genes of ACYL CARRIER PROTEIN Family Show Different Expression Profiles and Overexpression of ACYL CARRIER PROTEIN 5 Modulates Fatty Acid Composition and Enhances Salt Stress Tolerance in
Arabidopsis
. 2864 82
