Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0240066 (iron deficiency)
 7,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A patient with lung cancer treated by radiation and in remission presented with a two-month history of compulsive eating of raw, chilled potatoes. Suspicion of a pica due to iron-deficiency anemia was confirmed after complete laboratory evaluation. The source of iron loss was found to be gastrointestinal bleeding. Therapy with iron sulfate was begun, with a subsequent increase in the hemoglobin level; the pica ceased within one week of initiation of therapy. If searched for, pica is a common manifestation of iron deficiency; however, this patient apparently represents the first report of geomelophagia. Appropriate investigation of compulsive eating habits might lead to the diagnosis of iron deficiency and also allay patients' anxieties toward their behavior.
Am J Med 1982 Dec
PMID:Geomelophagia. An unusual pica in iron-deficiency anemia. 714 84

Rheumatoid arthritis is a systemic disease in which anaemia is common. The origin of the anaemia is usually multifactorial. Iron deficiency, a defect of release of iron from the reticulo-endothelial system is discussed. Ferritin content of monocytes, lymphocytes and polymorphs is found altered and mostly elevated in monocytes affected by serum iron deficiency. In all cell types iron uptake is related to transferrin saturation. Alterations against normal subjects in iron uptake, ferritin synthesis and iron incorporation into ferritin are mostly found in patients with serum iron deficiency.
Clin Rheumatol 1982 Dec
PMID:Serum ferritin and iron uptake by peripheral blood leucocytes in patients with active rheumatoid arthritis. 718 34

In an attempt to investigate the relationship of iron deficiency and mental status, cognitive development and attending behavior were assessed in nonanemic children aged 11 to 13 months who were severely or mildly iron deficient or were iron replete. Using two different approaches to the assessment of cognitive development and an habituation measure as an index of attending behavior, no statistically significant differences could be demonstrated in the overall level of performance between the iron-depleted and the iron-replete children. Isolated differences were demonstrated on a scale that measured fearfulness and on several of the scales that measured sensory areas of interest displayed.
Pediatrics 1981 Dec
PMID:Iron deficiency and behavioral deficits. 732 19

Until recent years, main biologic markers of inflammation used in current practice were limited to erythrocyte sedimentation rate, fibrinogen, and serum protein electrophoresis. A better understanding of inflammatory mechanisms and improvement of laboratories technologies helped in better understanding of the role and potential usefulness of inflammatory reaction proteins. Arrival of proteic profile and, more recently, the development of automation, still improved analysis of variations of different inflammatory reaction proteins. These proteins are then analyzed as an element of a "functional biological system", with known and so expected kinetics and ranges. The analyze of proteic profile combines the analyze of proteins variations, with elected but not exclusive associations, as Immunoglobulins and Complement, Orosomucoid and Haptoglobin, or Albumin and Transferrin. In Internal Medicine, proteic profile may help in solving daily problems. These problems may be so schematized: when the fundamental pathology is not yet known in an unraveling check-up, facing clinical symptoms, with a normal or fewly disrupted usual biologic panel, proteic profile may help to choose investigations necessary for the diagnosis; in the follow-up of patients treated for known inflammatory pathology facing new symptoms, part has to be done between complication of the disease and/or of the treatment, new pathology associated or unefficiency of the treatment. We report herein part of our experience of proteic profile in an Internal Medicine department, from some particularly demonstrative case reports: congenital or acquired abnormality of iron metabolism, with normal usual iron panel (iron deficiency, hemochromatosis); severe evolutive inflammatory or infectious disease with normal erythrocyte sedimentation rate (temporal arteritis, infectious endocarditis).
Allerg Immunol (Paris) 1993 Dec
PMID:[Importance of the protein profile in internal medicine]. 751 44

Animal experimentation has shown that early iron deficiency irreversibly affects brain iron content and distribution, resulting in neutransmitter and behavioural alterations. Even though extrapolation of animal data is often misleading, iron-deficiency anaemia has been consistently shown to be associated with psychomotor delays in infancy. The areas most involved are language and body balance. In these infants iron therapy, in most cases was not sufficient to reverse psychological effects even after complete correction of haematological measures. These findings may imply that the impact of iron-deficiency anaemia during infancy may be associated with irreversible adverse effects on cognitive performance. Careful follow-up studies of these infants at 5-6 years of age has shown that cognitive disadvantages persist, now assessed with a comprehensive set of psychological tests that reliably predict future competence. Thus, if once anaemia ensues, even timely and adequate iron therapy seems to be ineffective in reversing these behavioural and cognitive disadvantages; the only practical way to approach this problem is by prevention of iron deficiency in infancy. Health authorities, having been shown that treatment of iron deficiency anaemia is already too late to reverse potential deficits, should strive to prevent iron deficiency with adequate food fortification strategies or by supplementing targeted population groups.
Baillieres Clin Haematol 1994 Dec
PMID:Effect of iron-deficiency anaemia on cognitive skills in infancy and childhood. 753 64

A table was made of the composition of mineral and trace elements in different classes of French food items. The P, Ca, Mg, Fe, Cu, Zn, Mn, I and Se contents of the main categories of food are presented. The mineral and trace element intakes of the average French consumer were calculated from national survey data concerning all food items purchased by households. The intakes and the sources of the different elements are given related to the energy. These results were calculated for male and female adults receiving 2700 kcal and 2000 kcal, respectively, and compared with the recommended dietary allowances (RDA). Phosphorus and calcium intakes were adequate, as was iron for men. The intakes of Mg, Cu, Mn were between 80 and 100% of the RDA. For Zn, I, Se the intakes were lower (50-80% of the RDA). The iron deficiency observed in women is serious, and the selenium deficit in men may induce real biochemical subdeficiencies with clinical consequences.
J Trace Elem Electrolytes Health Dis 1994 Dec
PMID:The mineral and trace element composition in French food items and intake levels in France. 759 12

Magnesium (Mg) and iron (Fe) deficiency frequently develop during pregnancy. Therefore these factors were studied alone (Mg-L, resp. Fe-L) or in combination (Mg-L/Fe-L) on 16 female and 8 male adult fertile Sprague-Dawley rats. The animals were offered a basal diet containing 30 per cent and 17 per cent of the rat's requirement for magnesium and iron, respectively, starting 21 days before mating (2:1) until 49 days after mating. Offspring were also kept on this regimen during a 3-week lactation period and 7 days post weaning. Drinking water was either enriched with 101 ppm Fe2+ (ferrous gluconate): Mg-L, or 365 ppm magnesium (magnesium-L-aspartate hydrochloride trihydrate, MAH): Fe-L, or with any: Mg-L/Fe-L or with both electrolytes: Controls. Fertility remained unaffected under these conditions. Clinically, Fe-L induced iron deficiency and growth retardation of offspring. Pronounced reproductive toxicity was elicited by Mg-L and was even potentiated by Mg-L/Fe-L. In the parental generation, too, adverse effects of Mg-L were aggravated by Mg-L/Fe-L despite the fact that no iron accumulation occurred. Bioavailability of iron was not impaired by magnesium as MAH. With respect to human pregnancy magnesium supplementation has higher priority over iron supplements. To improve tolerance and compliance both minerals are suggested to be taken simultaneously.
Magnes Res 1994 Dec
PMID:Potentiation of magnesium-deficiency-induced foetotoxicity by concomitant iron deficiency and its prevention by adequate supply via drinking water. 778 87

Well-child care provides opportunities for nutrition education and the prevention of nutritional diseases. It is important to look at not only the food that is eaten but the relationships in which the food is offered. Significant impacts on the prevalence of iron deficiency and poverty-related malnutrition are possible. More research is needed on cholesterol reduction and on the prevention and treatment of obesity.
Prim Care 1994 Dec
PMID:Childhood nutrition: from breastmilk to burgers. 785 57

This chapter discusses different methods to prevent iron deficiency--to reduce iron losses (e.g. reducing menstrual iron losses by using a contraceptive pill or combating of hookworm infestation) or to increase iron absorption. Iron absorption can be increased (1) by modifying the composition of meals--increasing the content of dietary factors enhancing iron absorption (e.g. meat and ascorbic acid) or reducing the content of factors inhibiting iron absorption such as phytate and iron-binding phenolic compounds, (2) by increasing the iron content of the diet by fortification with iron, or by (3) supplementation with iron tablets. Several factors to consider in the choice of strategy are discussed such as the importance of the bioavailability of the diet for the efficacy of iron fortification, the choice of vehicle for iron fortification that is compatible with the iron compound used, the feasibility to increase the bioavailability of the dietary iron by modification of the composition of the diet and the short time available in pregnancy to ensure a sufficient supply of the extra iron needed limiting the effective measures available to supplementation with iron tablets.
Baillieres Clin Haematol 1994 Dec
PMID:Prevention of iron deficiency. 788 Nov 55

Serum iron concentrations were studied in two groups of Hausa women, one of pregnant subjects attending the antenatal clinics at a health centre and one of lactating subjects attending the centre's postnatal clinics. It was thought possible that the normal diet of the pregnant women had sufficient iron content to meet the women's increased demands for this metal. Of the pregnant women, 17% had serum iron concentrations of < or = 490 micrograms/litre [14% with microcytic hypochromia and a mean cell haemoglobin concentration (239 +/- 2 g/litre) indicative of iron deficiency, plus 3% with normocytic-microcytic hypochromia] and 7% had normocytic-microcytic cells and 525 +/- 25 micrograms iron/litre of serum. The low serum iron in 17% of the pregnant women may be the result of repeated pregnancies without proper child spacing, leading to maternal iron deficiency syndrome, or of infestation by the parasites that are prevalent in rural areas, or to both. None of the lactating mothers was found to be iron deficient and there were apparently no cases of haemosiderosis. Mean (+/- S.D.) blood haemoglobin concentrations (87.5 +/- 1.3 g/litre), packed cell volumes (32 +/- 3.2%), mean cell haemoglobin concentrations (274 +/- 37 g/litre) and serum iron concentrations (735 +/- 261 micrograms/litre) were all significantly lower in the pregnant women (P < 0.001) than in the lactating women (105.7 +/- 12.9 g/litre, 36.8 +/- 3.4%, 288 +/- 32 g/litre and 1154 +/- 277 micrograms/litre, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
Ann Trop Med Parasitol 1994 Dec
PMID:Diet and serum iron status in pregnant and lactating Hausa women in Kano State, Nigeria. 789 83


<< Previous 1 2 3 4 5 6 7 8 9 10