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Query: UMLS:C0240066 (iron deficiency)
 7,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hemodialysis (HD) patients with functional iron deficiency (FID) often develop resistance to recombinant human erythropoietin (Epo). The contributory role of chronic inflammation and oxidative stress in its pathogenesis is poorly understood. We assessed the effect of vitamin C, an antioxidant, on Epo-hyporesponsive anemia in hemodialysis patients with un-explained hyperferritinemia levels. Thirty-one of 132 with Hb 15 patients received standard care and 300 mg of intravenous vitamin C with each dialysis session (group 1) and 15 patients received standard care (group 2). After 3 months, Hb and transferrin saturation levels significantly increased in group 1 but not in group 2 (p < 0.05%). Hemoglobin content in reticulocyte and serum ferritin decreased significantly in group 1 but not in control group. In conclusion, hemodialysis patients with refractory anemia and adequate iron stores, vitamin C improved responsiveness to Epo by augmenting iron mobilization and possibly via antioxidant effect.
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PMID:Effect of intravenous ascorbic acid in hemodialysis patients with anemia and hyperferritinemia. 1897 79

The present study was designed to evaluate the effect of a new iron tonic (squid ink melanin-Fe [SM-Fe]) on remission of iron deficiency anemia (IDA) using a rat model of IDA. The rat IDA model was established with low-iron diet feeding and caudal vein blooding. Then different dosages of SM-Fe were given to the rats once a day by intragastric administration, with FeSO4 and FeCl3 as positive control. The content of Hemoglobin (Hb), red blood cell (RBC), hematocrit (HCT), and mean corpuscular volume (MCV) were analyzed in addition to the contents of serum iron (SI) and intracellular free erythrocyte protoporphyrin (FEP). The content of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in serum was also measured. The results showed that anemia caused by iron deficiency was established as a consequence of the low-iron diets. SM-Fe showed an effective restoration action by returning Hb, RBC, HCT, MCV, SI, and FEP in IDA animals to normal values. An antioxidant effect was also observed that reduced MDA level, enhanced the activities of SOD and GSH-Px in serum, and protected erythrocytes from the injury of reactive oxygen species as a consequence of SM-Fe intake. In comparison with FeSO4 and FeCl3, higher bioavailability of iron and fewer side effects were also observed. In conclusion, SM-Fe remitted iron deficiency anemia symptoms significantly, suggesting that SM-Fe might contribute to improving hemopoietic function in IDA rats and might be exploited as a safe, efficient new iron tonic.
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PMID:Effect of squid ink melanin-Fe on iron deficiency anemia remission. 1901 17

The main purpose of this study was set up to determine iron deficiency and anemia due to iron deficiency among the women in villages around of Gorgan. The comparison of three groups (Fars-native, Turkman and Sistanee) that living in this area and comparison of pregnant and non-pregnant about hematological indexes are other objectives of this study. By random-clustering method were chosen 415 women of 18-35 years old in 20 villages of Gorgan. Gorgan district located in north of Iran and south-east of Caspian sea. In the pregnant women, serum Iron less than 30 microg dL(-1), Hemoglobin (Hb) less than 11 g dL(-1), transferrin saturation (T.S) less than 16% were be consider as anemia point and in non-pregnant women, this point is the serum iron less than 40 microg dL(-1), Hb less than 12 g dL(-1) and TS less than 16%. The prevalence of Iron Deficiency (ID), Anemia and Iron Deficiency Anemia (IDA) were 35.6% (149), 25.8% (107) and 13.5% (56), respectively. Positive correlation exist between serum Iron and Hb (p < 0.0001, r = 0.335), HCT (p < 0.01, r = 0.1581), MCH (p < 0.01, r = 0.1661) and MCHC (p < 0.001, r = 0.262). The prevalence of ID in Fars-native, Turkman and Sistanee women were 33.6, 47.6 and 26.2%, respectively. The rate of anemia on the same women were 27.7, 18.75 and 22.33% and IAD were 15.6, 11.9 and 11.3%, respectively. Chi2-test showed a meaningful difference in regard to ID and anemia among the three groups of women (p < 0.005). A statistical significant correlation was seen between Hb and MCHC (r = 0.467, p < 0.001). In pregnant women, the prevalence of the anemia on the basis of serum iron index, T.S and Hb were seen 24.2, 42.4 and 18.2%, respectively, versus non-pregnant women were 21.2, 34.55 and 20.98%. In summary, can be concluded that the prevalence of anemia its characteristic also is one of the women nutritional problems in the villages around the Gorgan and it is different among the three groups of women and in Fars-native is higher than other groups. Too, anemia is a nutritional problem in pregnant women.
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PMID:Anemia in north of Iran (south-east of Caspian Sea). 1908 21

Infants and toddlers are particularly vulnerable to developing iron deficiency, which can cause irreversible deficits in neurodevelopment. Children at highest risk include premature and low birth weight infants, those who are fed cow's milk rather than breast milk or formula prior to age one, and those who drink large amounts of cow's milk as toddlers. It is important to detect iron deficiency before it becomes frank anemia through the use of appropriate laboratory tests. Hemoglobin or hematocrit testing, at around age one, has been the usual screening test. These tests, however, do not become abnormally low until frank anemia has developed. Over the past decade, research has shown the assay for reticulocyte hemoglobin content to be a much earlier indicator of iron deficiency. This article provides an overview of the epidemiology, occurrence, and detection of iron deficiency and iron deficiency anemia in young children as well as a comparison of the utility of various laboratory tests.
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PMID:Occurrence and detection of iron-deficiency anemia in infants and toddlers. 1917 83

Hemoglobin E (HbE) is one of the most prevalent beta-globin variant, which is widely distributed in Southeast Asia especially in Thailand. Homozygosity for this variant is common and may occur with iron deficiency. In order to study clinical and hematological phenotypes without the confounding effect of iron deficiency, investigations were carried out before and after iron supplementation for 2 months. The effect of G6PD deficiency and coinheritance of alpha-thalassemia in homozygous HbE were also studied. HbE homozygotes were clinically benign, never had been transfused and had no hepatosplenomegaly. Out of 76 HbE homozygotes, hematological parameters of 7 individuals with iron deficiency improved after iron supplementation. Hemoglobin analysis revealed that HbE was the main hemoglobin detected, but 12 subjects were found to have a substantial percentage of HbF, which might lead to misdiagnosis as HbE/beta-thalassemia. Both clinical and hematological phenotypes of simple homozygous HbE did not differ from those who also inherited alpha-thalassemia and/or G6PD deficiency. It is necessary to perform a comprehensive DNA analysis for alpha-thalassemia in cases of homozygous HbE when their partner is suspected of having alpha-thalassemia 1 gene.
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PMID:Clinical and hematological phenotype of homozygous hemoglobin E: revisit of a benign condition with hidden reproductive risk. 1932 16

One hundred and three patients from Gilan Province, Iran, presenting with hypochromic and microcytic anemia parameters without iron deficiency were included in this study. Using gap-polymerase chain reaction (gap-PCR), reverse hybridization StripAssay and DNA sequencing, we detected a total of 113 alpha-globin mutations in 94 (91.3%) of these patients. Most prevalent of the 16 different alpha-thalassemia (alpha-thal) alleles was -alpha(3.7) (42.5%), followed by the polyadenylation signal (poly A2) (AATAAA>AATGAA) (12.4%), Hb Constant Spring [Hb CS, alpha142, Term-->Gln (TAA>CAA in alpha2] (10.6%), --(MED) (8.8%), IVS-I donor site [GAG GTG AGG>GAG G-----, alpha(-5 nt) (-TGAGG)] (7.1%), -alpha(4.2) (4.4%) and poly A1 (AATAAA>AATAAG) (3.5%). An additional nine mutations were observed at frequencies below 2%. We also found two novel alpha1 gene mutations: alpha(-9) (HBA1: c.-9 G>C) and alpha(IVS-I-4) (HBA1: c.95+4 A>G). Our new findings will be valuable for improving targeted thalassemia screening and prevention strategies in this area.
Hemoglobin 2009
PMID:Alpha-thalassemia mutations in Gilan Province, North Iran. 1965 38

Blood samples were collected from 699 patients attending out patient clinics in Sana'a City, Yemen, to obtain some idea of the prevalence of the thalassemias in our country. Complete blood count, hemoglobin (Hb) electrophoresis, quantitation of Hb A(2) and Hb F, and serum ferritin were determined. Microcytic, hypochromic red cells were found in 103 subjects (14.7%). Iron deficiency alone accounted for only a small proportion of these (n = 12), whereas features suggestive of beta-thalassemia (beta-thal) were present in 31 patients (4.43%) and features suggestive of alpha-thal trait were found in 60 patients (8.6%). The study showed that thalassemia probably accounts for most red cell microcytosis in these out patient clinics, and could represent a significant health problem through births of homozygotes and compound heterozygotes with severe disorders. This pilot study should be repeated with improved technology, and extended to include globin gene analysis to define the nature of the disorders that remain poorly diagnosed.
Hemoglobin 2009
PMID:Thalassemia trait in outpatient clinics of Sana'a City, Yemen. 1965 39

Hemoglobin (Hb) levels and mean corpuscular volume (MCV) are abnormal in some persons with hemochromatosis or thyroid disorders. We sought to determine whether serum free thyroxine (T4) affects erythrocyte measures in euthyroid adults with or without C282Y homozygosity. We evaluated 488 white HFE C282Y homozygotes and controls (no HFE C282Y or H63D; normal serum iron measures) identified in screening; we excluded those with thyroid disorders, anemia, erythrocytosis, or serum ferritin (SF) <34 pmol/l. In the remaining 141 C282Y homozygotes and 243 controls, we evaluated correlations of log(10) free T4 with Hb, RBC, MCV, and red blood cell distribution width (RDW). C282Y homozygotes had lower mean age, higher mean Hb, MCV, and log(10) SF, and lower mean RBC and RDW than controls; mean log(10) free T4 did not differ significantly. In HFE C282Y homozygotes, there was no significant correlation of log(10) T4 with erythrocyte measures. In controls, there was a positive correlation of log(10) T4 with Hb (P = 0.0096) and a negative correlation with RDW (P = 0.0286). Among euthyroid white adults without iron deficiency, there are significant correlations of log(10) free T4 with Hb and RDW in controls, but not in HFE C282Y homozygotes.
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PMID:Relationships of serum free thyroxine and erythrocyte measures in euthyroid HFE C282Y homozygotes and control subjects: the HEIRS study. 1970 67

Iron deficiency anemia (IDA) remains a word public health problem, particularly in children and child-bearing-age women. Iron demands need to be covered by adolescent women due to the increased physical growing, menstruation, pregnancy and fetal growing tissues at this life stage. This study was proposed to investigate the prevalence of iron deficiency and IDA in pregnant adolescent women from Northwestern Mexico. Participated 186 women under 19 years old during the first or second trimester of pregnancy who attended the local health institutions in Hermosillo Sonora. Questionnaires and 24 hr recalls were administered to collect socioeconomic and dietary information respectively. Hemoglobin (Hb), hematocrit, ferritin and eritrocytic protoporphyrin were measured. Hb and ferritin values were used to categorize the recruited women into normal (37.4%), iron deficient (55.5%) and IDA (7.1%) groups. Six and seven women showed moderated and light anemia status in the IDA group. Fe and fiber intake and weeks of pregnancy were associated with the biochemical indicators of iron at least in two women groups. The high percentage of iron deficient women in this study is demanding the identification and attention of maternal factors and food habits that are risk of iron deficiency in pregnant women.
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PMID:[Prevalence of iron deficiency and iron deficiency anemia in pregnant adolescents from northwest Mexico, 2007-2008]. 1971 10

The study enrolled 177 women with gynecological cancer and 132 with gynecological disease. Hemoglobin (Hb), mean corpuscular hemoglobin (MCH), red blood cells (RBC), and erythrocyte sedimentation rate (ESR) were analyzed. The gynecological patients with anemia showed a correlation between Hb and MCH (p < 0,05), which is indicative of iron deficiency. In the gynecological cancer patients, the correlation between Hb and MCH was significant (p < 0,01), that between Hb and RBC was strong (p < 0,001), suggesting the reductions in both erythropoiesis and Hb synthesis in the erythrokaryocytes. In these patients, anemia results from chronic diseases. The gynecological cancer patients were found to have higher ESR and lower Hb, RBC, and MCH than the gynecological patients.
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PMID:[Comparative analysis of erythrocytic indices in patients with gynecological diseases and gynecological neoplasms]. 2020 73


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