Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0240066 (
iron deficiency
)
7,156
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Bisphenol A
(
BPA
), an estrogenic environmental contaminant is also known for oxidative stress-inducing effect. Malnutrition is recognized as a confounding factor in oxidative stress. However, little is known about effect of malnutrition on oxidative stress induced by
BPA
or other endocrine disrupting chemicals (EDCs). We studied effect of malnutrition (
iron deficiency
) in rats chronically exposed to low levels of
BPA
taking into consideration the oxidative stress and antioxidant status in liver, kidney and gonads.
Iron deficiency
significantly elevated level of lipid peroxidation in
BPA
-exposed rats. Similarly, decrease in reduced glutathione level was more significant in rats maintained on iron deficient diet compared to those maintained on normal diet.
Iron deficiency
also significantly modulated activities of vital antioxidant enzymes in all the tissues. Female rats showed more vulnerability than males to iron-deficiency modulated effects of
BPA
on the above parameters. This study demonstrated that malnutrition, especially
iron deficiency
, might act as a confounding factor in EDC-induced oxidative stress. However, more studies may be needed to confirm effect of nutritional factors on estrogenic activity of
BPA
or other EDCs.
...
PMID:Iron deficiency augments bisphenol A-induced oxidative stress in rats. 1904 62
