Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0240066 (iron deficiency)
 7,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This article discusses the living environment and nutritional status of the girl child in India: dwelling, water source, toilet facilities, diet, literacy status, physical growth pattern, infant mortality, and micronutrient deficiencies. During 1974 and 1980, the normal nutritional pattern of pre-school age children improved. Stunting fluctuated and gradually declined from 57.9% to 44.8%. Wasting declined from 3.5% to 2.4%. Stunting and wasting declined from 3.3% to 2.0%. 8% of children 0-3 years old had vitamin A deficiencies, and 20% of children 3-6 years old had vitamin A deficiencies. Vitamin A deficiencies were highest at 41% among children 10-15 years old. Iron deficiencies ranged from 12% to 48%. The highest deficits were in younger age groups. Girl children begin household chores at the age of 5 years. By the age of 15 years, girls may work 10 hours a day at housework. Girls who obtain water at a distance from the home experience drains in energy from an undernourished body. Women who fetch water are not able to look after their children properly. Unsafe water, unsanitary toilet facilities, and poor sanitation contribute to morbidity and ill health. The proportion of boys reaching secondary levels of schooling was 2-4 times higher than girls. Girls tend to be about 2 cm shorter at birth. Gender gaps in height were wider at 3 years of age. Weight deficits of girls increased from about 5 kgs at 6 years of age to 20 kgs at 15 years of age. Height deficits of almost 8 cm at 6 years of age doubled by 15 years of age. Poorly nourished mothers tend to give birth to low birth weight (LBW) babies (under 145 cm and below 40 kg). LBW babies tend to show poor growth in weight and height over time. The cycle of poor nutrition, poor health, and unsanitary living conditions repeats itself.
 ...
PMID:Girl child and environment. 1215 12

Table salt can now be fortified with iodine and iron without interaction and without loss of potency. According to Levente Diosady, professor of Food Engineering at the University of Toronto, the amounts of the two micronutrients available to the human body have been significantly reduced when the two interacted. In the new technology, the iodine is covered with a dextrin (a water soluble starch) capsule that serves as a physical barrier to the iron. Micronutrient Initiative (an international secretariat based at IDRC that works to eliminate health problems resulting from iron, iodine, and vitamin A deficiencies) and IDRC supported the development of the technology. The efficiency of absorption of the two micronutrients in the new double fortified salt in the human body is being tested at the Hospital for Sick Children in Toronto. Later testing will be conducted by University of Ghana scientists in IDRC-funded trials that will focus on women and their families in areas of Ghana where these deficiencies are endemic. Iodine is part of thyroid hormone, which contributes to brain development in the fetus and regulates human metabolism; iodine deficiency is the most frequent cause of preventable mental retardation. Related disorders include lethargy, physical disabilities, goiter, stillbirth, and neonatal death. Iron deficiency, the most common nutritional problem in the world (particularly among women, infants, and children), is associated with anemia, fatigue, learning problems, pregnancy complications, premature births, and maternal mortality. The two deficiencies together affect more than one-third of the world's population. Approximately 1.6 billion people, in more than 100 countries, live in areas where iodine is not available in sufficient amounts; those most at risk include about one-third of China's population. It is also a severe problem in the Himalayas, the Andes, India, and West Africa.
 ...
PMID:Micronutrient deficiencies. Reports from the field -- Africa. 1229 Mar 27

India has achieved self-sufficiency in the production of food grains, yet the production of milk, legumes, vegetables, oils and fats, eggs, and meat is far short of the needs of the population. The Indian diet predominantly comprises cereals, and the diets of expectant and nursing mothers as well as children are grossly deficient in protective foods. Serious nutritional inadequacies have resulted in low birth weight, retarded growth, and nutritional deficiencies (protein energy malnutrition in preschool children, vitamin A deficiency, iron deficiency in women of reproductive age, and iodine deficiency disorders among neonates and schoolchildren). General malnutrition is prevalent in 25% of the rural and 20% of the urban population. Deficiency symptoms of vitamin B complex and vitamin C are also not uncommon. 37% of the population of India lives below the poverty limit, the literacy rate is only 52.1% (39.4% for women), safe drinking water is scarce, nutritional ignorance is rampant, there is a lack of personal hygiene, and poor sanitation all account for malnutrition. A number of government and nongovernmental organizations' programs have attempted to raise the level of nutrition and the standard of living of the people. Some of them include the integrated child development services, special nutritional program, national vitamin A deficiency prophylaxis program, national anemia prophylaxis program, national goiter control program, midday meal program, special class feeding programs, universal immunization program, nutritional and health education through the mass media as well as the observance of world food day and world health day. The national health policy gives high priority to the promotion of family planning, the provision of primary health care, and the acceleration of welfare programs for women and children. As a result of policies and programs of health and nutrition, the infant, child, and maternal mortality rates have declined and life expectancy at birth has risen.
 ...
PMID:Strategies for nutritional improvement. 1234 51

Iron deficiency and iron-deficiency anemia are common in the developing world. We evaluated the feasibility of iron fortification of domestic drinking water to prevent and control iron deficiency and iron-deficiency anemia. Twenty-one families representing 88 persons, including children, were selected to participate in this study. Twelve families added an iron solution plus ascorbic acid to their domestic drinking water over a four months period and nine families added a placebo. Blood samples were collected, before and after the four months, for hemoglobin and serum ferritin measurements. Iron-fortified drinking water increased hemoglobin (children 10.9 +/- 1.1 g/dl to 11.7 +/- 1.1 g/dl p < .01, adults 12.9 +/- 1.7 g/dl to 13.7 +/- 1.7 g/dl p < .01) and ferritin (children 27.6 +/- 21.6 ng/dl to 33.8 +/- 22.1 ng/dl, adults 74.8 +/- 41.3 ng/dl to 106.2 +/- 93.9 ng/dl p < .05). No significant changes in hemoglobin and ferritin were found in the placebo group after 4 months. Preparation, distribution, and consumption of the solutions were successful. Iron fortification of household drinking water can be a simple and effective alternative to deal with iron deficiency and iron-deficiency anemia in less developed areas.
 ...
PMID:Domestic drinking water--an effective way to prevent anemia among low socioeconomic families in Brazil. 1236 99

Spatone Iron-Plus is a naturally occurring mineral water from Trefriw Wells Spa in Conwy County, North Wales, UK. It contains approximately 0.20 mg of iron per millilitre as ferrous sulphate and has been shown to provide iron in a highly bio-available form. A 24 ml sachet contains approximately 5 mg of iron. Iron deficiency is common in the obstetric population. However, compliance with traditional iron supplements is poor because of gastrointestinal side-effects. We designed a randomized, double-blind, placebo-controlled trial. A total of 102 low-risk antenatal patients, who were noncompliant with routinely prescribed ferrous sulphate tablets, were randomized to receive 48 ml of Spatone water or placebo. The study was conducted between 22 and 28 weeks gestation. Primary outcome measures were compliance, gastrointestinal side-effects and changes in ferritin levels during the trial period. Compliance in the intervention group was 57% compared with 67% in the control group, P = 0.22. Dyspepsia scores, as determined by a recognized and well-validated questionnaire, did not differ between the two groups. During the trial period, mean ferritin levels fell by 24% in the Spatone Iron-Plus group compared with a mean fall of 51% in ferritin levels among the control group, P = 0.016.
 ...
PMID:A randomized trial investigating an iron-rich natural mineral water as a prophylaxis against iron deficiency in pregnancy. 1264 13

The authors assessed the effect of water reconstitution in the workplace by evaluating the iron status of manganese mine workers during a long-term study. Subsequent analyses and biological monitoring were performed in a group of 150 manganese miners before, and 2.8 yr after, reconstitution of drinking water in the miners' workplace. The authors found significantly high concentrations of manganese in the workplace well water, as well as in the miners' blood, urine, and hair. There was a considerable prevalence of epithelial lesions, which resulted from iron deficiency, in the miners, compared with controls. The authors assessed the prevalence of iron deficiency grades (i.e., I > II > III > IV) before and after water reconstitution. Reconstitution of drinking water for the ultimate attainment of healthy levels of manganese and other minerals resulted in a significant improvement in the miners' iron status and a decreased prevalence of epithelial lesions. The authors concluded that alterations in iron status may result from the cumulative effect of high levels of manganese in consumed water, as well as in airborne dust, in the workplace. Such elevated levels should be considered as an occupational hazard because they have an ability to interfere with iron absorption.
 ...
PMID:Long-term follow-up of workplace and well water manganese effects on iron status indexes in manganese miners. 1269 48

Iron deficiency (ID) is among the most common nutritional diseases, causing deleterious effects that include decreases in cognitive function and weight loss. The ID also induces a reduction in the number and affinity of dopaminergic D2 receptors. The new finding that ID induces an increase in the pancreas cells, leads to the hypothesis that cholecystokinin-8 (CCK-8) is involved in the ID effects. The level of CCK-8 was higher among ID rats, compared with normal rats. The ID rats in our study were anorectic and performed poorly in learning tests (Morris water maze and passive avoidance learning). Essential fatty acids (EFA) mediate dopamine activity and have been found to rehabilitate learning deficits. Treatment with a fatty acid compound blocked both the learning deficits and the anorexia, while a CCK-8 antagonist was successful only against the anorectic effects.
 ...
PMID:The effects of an essential fatty acid compound and a cholecystokinin-8 antagonist on iron deficiency induced anorexia and learning deficits. 1527 94

Phytic acid is a potent inhibitor of native and fortification iron absorption and low absorption of iron from cereal- and/or legume-based complementary foods is a major factor in the etiology of iron deficiency in infants. Dephytinization of complementary foods or soy-based infant formulas is technically possible but, as phytic acid is strongly inhibitory at low concentrations, complete enzymatic degradation is recommended. If this is not possible, the phytic acid to iron molar ratio should be decreased to below 1:1 and preferably below 0.4:1. Complete dephytinization of cereal- and legume-based complementary foods has been shown to increase the percentage of iron absorption by as much as 12-fold (0.99% to 11.54%) in a single-meal study when the foods were reconstituted with water. The addition of milk, however, inhibits iron absorption and overcomes the enhancing effect of phytic acid degradation. Dephytinization can therefore be strongly recommended only for cereal/legume mixtures reconstituted with water, especially low-cost complementary foods destined for infants in developing countries. In countries where infant cereals are consumed with milk, ascorbic acid addition can more easily be used to overcome the negative effect of phytic acid on iron absorption. Similarly with soy-based infant formulas, especially if manufactured from low-phytate isolates, ascorbic acid can be used to ensure adequate iron absorption.
 ...
PMID:Phytic acid degradation as a means of improving iron absorption. 1574 20

In 1985, Paterson and Bettger found hypoplastic hematopoiesis in severely zinc-deficient rats. Therefore, we investigated plasma erythropoietin concentration in zinc-deficient rats. Forty 4-wk-old male Sprague- Dawley rats were assigned into 4 dietary treatment groups of 10 for the 4-wk study: zinc-deficient group (4.5 mg zinc and 35 mg iron/kg; -Zn), iron-deficient group (30 mg zinc/kg, no supplemental iron; -Fe), zinc/ iron-deficient group (4.5 mg zinc/kg, no supplemental iron; -Zn-Fe), and control group (AIN-93G; Cont). Water intake determined at d 19 was similar among all treatment groups. At d 27-28, bioimpedance was measured. The intracellular water/extracellular water ratio was significantly increased in the -Zn group (p < 0.05). Compared to the Cont, group, the plasma erythropoietin concentration was increased by iron deficiency and decreased by zinc deficiency (p < 0.01). Hematocrit was significantly decreased in both the -Fe and -Zn-Fe groups and was significantly increased in the -Zn group (p < 0.01). Transferrin saturation in the -Fe and -Zn-Fe groups was significantly lower than the Cont group (p < 0.01), and that of the -Zn group was highest among all groups. The low plasma erythropoietin concentration might account for depressed hematopoiesis associated with zinc deficiency.
 ...
PMID:Zinc deficiency decreases plasma erythropoietin concentration in rats. 1628 84

Pica, the compulsive ingestion of non-food substances, is a common, yet less well known symptom of iron deficiency anemia (IDA). Ice eating or pagophagia is one of the most common forms of pica associated with iron deficiency and IDA, and has only recently been identified among patients who had undergone Roux-en-Y gastric bypass (RYGBP). This article presents additional cases of pagophagia in women which emerged after RYGBP and resolved with iron treatment. These cases, added to the literature, lead to further discussion of how healthcare providers can subtly probe patients for the presence of pica.
 ...
PMID:Emergence of pica (ingestion of non-food substances) accompanying iron deficiency anemia after gastric bypass surgery. 1635 33


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>