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Query: UMLS:C0240066 (iron deficiency)
 7,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The iron-containing protein cytochrome P-450 is present in high concentration in the adrenal cortex and is involved in the synthesis of corticosterone. This study was designed to determine the cortisol response to adrenocorticotropin (ACTH) in patients with severe iron deficiency. Eleven patients with iron deficiency and 15 normal controls were studied. Fasting blood samples were taken from all the subjects before and 30, 60 and 120 min after infusion of 25 units of ACTH for plasma cortisol determination. Six patients had blood samples collected at night, too. The same test was performed in 6 patients with iron deficiency, 7 days after therapy with 800 mg of ferrous sulfate. No significant differences were observed between patients and controls for the baseline cortisol values. The cortisol secretion and the increment at 30, 60 and 120 min after ACTH infusion were significantly lower in patients than in controls, either before or after ferrous sulfate therapy. There were no significant differences between baseline and stimulated cortisol values in patients before and after 7 days of ferrous sulfate therapy. There was no change in cortisol secretion rhythm in patients with iron deficiency (cortisol level at night = 5.1 +/- 4.3 micrograms/dl). In conclusion, the results of the present study showed that, in patients with severe iron deficiency, the cortisol secretion after ACTH stimulation was decreased.
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PMID:Reduced cortisol secretion in patients with iron deficiency. 165 78

This study was designed to determine the ACTH-corticosterone response to two types of stress in relation to the daily rhythm of food and water intake in the iron-deficient rat. Rats were fed diets containing 2, 10 or 50 mg iron/kg diet between weaning at 21 days and the stress experiments at 38 or 42 days of age. The two iron-deficient diets (2 and 10 mg iron/kg) resulted in mean hemoglobin concentrations of about 6.0 and 8.5 g/dl, respectively, in contrast to about 12.5 g/dl in the control group receiving 50 mg iron/kg diet. Food and water consumption followed the normal nocturnal pattern, irrespective of iron intake. ACTH and corticosterone showed the normal baseline peaks at the 2000 hour lights-out point in all groups. Responses to handling and placement into another cage were similar in most respects but suggested an inappropriately low corticosterone response despite high ACTH values only at the 2000 hour point. However, there was no evidence of similar differences in response to the more potent stress of an i.p. injection of histamine 1 mg/100 g body weight. In contrast to the reports of more clear-cut effects of iron deficiency on norepinephrine, the changes in ACTH and corticosterone response to stress seem relatively modest.
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PMID:The pituitary-adrenal response to stress in the iron-deficient rat. 609 Jun 19