Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0240066 (
iron deficiency
)
7,156
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Monoclonal antibodies ED1 and
ED2
can recognize epitopes on the spleen macrophage related with its antigen presenting activity. Immunohistochemical and histochemical methods were used to show the influence of iron overload and
iron deficiency
on the expression of ED1,
ED2
and phagocytic functions of the macrophages in the spleen. We found that iron overloaded rats had large amounts of hemosiderin deposits in the macrophages of red and white pulp with reduced expression of ED1,
ED2
and phagocytic function. It is suggested that iron concentration can regulate the expression of ED1,
ED2
and phagocytic activity of the macrophage, which may in turn influence its antigen presentation and anti-infection functions.
...
PMID:[Iron overload and iron deficiency regulate ED1 and ED2 expression in spleen macrophages of rats]. 778 Nov 10
