Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0240066 (
iron deficiency
)
7,156
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The vitamin B
12
status of infants depends on maternal B
12
status during pregnancy, and during lactation if breastfed. We present a 9-month-old girl who was admitted to the metabolic unit for assessment of developmental delay. She was exclusively breastfed and the introduction of solids at 5 months was unsuccessful. Investigations revealed pancytopenia, undetectable B
12
and highly elevated methylmalonic acid and homocysteine.
Methylmalonic acid
and homocysteine normalised following B
12
injections. Marked catch-up of developmental milestones was noted after treatment with B
12
. Investigations of parents showed normal B
12
in the father and combined B
12
and
iron deficiency
in the mother. Maternal B
12
deficiency, most likely masked by
iron deficiency
, led to severe B
12
deficiency in the infant. Exclusive breastfeeding and a subsequent failure to wean exacerbated the infant's B
12
deficiency leading to developmental delay. This case highlights the need for development of guidelines for better assessment of B
12
status during pregnancy.
...
PMID:An infant and mother with severe B
12
deficiency: vitamin B
12
status assessment should be determined in pregnant women with anaemia. 2853 76
