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Query: UMLS:C0240066 (iron deficiency)
 7,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Rats of Wistar strain, of same age, were kept on iron free diet up to nearly absolute iron deficiency in iron depots. Afterwards granuloma was produced by implantation of cotton pellets subcutaneously. For characterization of the collagen biosynthesis in the granuloma the neutral salt soluble collagen and the activity of the prolyl hydroxylase were measured in the granuloma 4, 8 and 12 days after cotton pellet implantation. At the same time "collagen-like" protein was determined in the serum of the animals. The enzyme activity was statistically significant lower in the granuloma of animals on iron deficiency than in the granuloma of the comparable groups on normal diet. Statistically significant higher concentration of neutral salt soluble collagen was found 8 and 12 days after cotton pellet implantation in the group on iron free diet. There was no significant difference as to the serum levels of "collagen-like" protein in serum.
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PMID:[Parameters of collagen biosynthesis in cotton pellet granuloma of rats on iron deficiency (author's transl)]. 21 Apr 87

In a random population of 198 pregnant women, detailed haematological determinations were performed at delivery. The prevalence of anaemia (haemoglobin less than 10 g/100 ml) is 20%. Iron deficiency is even more frequent. Malaria is shown to play an important role. Maternal anaemia is also correlated with nutritional status. Primiparae are shown to be at higher risk of anaemia. The effect of maternal anaemia on anthropometric and haematological variables of the newborn are discussed. Mothers with sickle-cell or HbC trait are not at special risk of anaemia.
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PMID:Maternal anaemia in Abidjan--Its influence on placenta and newborns. 21 75

The analysis of cord blood samples of 198 African newborns and their mothers confirmed the high prevalence of iron deficiency. A hypochromia and microcytosis of red cells was found in 40% of the pregnant women at term. In the majority of newborns the haemoglobin concentration was below 16 g/100 ml. Hb S was found in 11%, Hb C in 9% and alpha-thalassaemia in 2% of the population examined. Haemoglobin, packed cell volume and mean cell volume of erythrocytes were lower than results of newborns from developed countries. Foetal sex had no influence on haematological variables.
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PMID:Haematological data of African newborns and their mothers in Abidjan. 21 78

Iron deficiency causes cytological and enzymic changes in the gastrointestinal mucosa of animals and man that can be expected to impair the digestion and absorption of other nutrients. In experiment 1, healthy, weanling, female rats were grouped into pair-mates and pair-fed either an iron-deficient or an iron-supplemented diet for 19 weeks. In experiment 2, iron-deficient offspring reared by iron-deficient females were grouped into pair-mates and pair-fed either an iron-deficient or an iron-supplemented diet for 15 weeks. In experiment 1, apparent absorption of calcium was significantly depressed in week 9 (p less than 0.001) and slightly depressed in weeks 10 and 11. In experiment 2, the apparent absorption of calcium was significantly (p less than 0.001) depressed in weeks 6, 13, and 14. Absorption was not measured in other weeks in these experiments. The concentrations of calcium and magnesium were consistently higher in the fecal dry matter of the iron deficient rats in both experiments. It was concluded that any defects in digestion and absorption by the iron-deficient rats was confined primarily to the mineral nutrients because in both experiments apparent absorption of dry matter was consistently higher in these animals compared to their iron-supplemented pair-mates.
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PMID:Utilization of dietary calcium by iron-deficient rats. 24 Oct 35

In two separate trials, 140 cases of Pregnancy Anaemia were investigated in the University Teaching Hospital, Lusaka. The distribution of anaemia was as follows: Iron deficiency 118 (84.2%); dual deficiency 15 (19.7%); haemolytic five (35%); and megaloblastic 2 (1.4%). Anaemia with megaloblastic change was more common in the second study.
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PMID:Anaemia in pregnancy--a report of two trials. 26 63

Longitudinal studies of physical development in the first year of life were carried out in the group of children born with low body weight. Results were compared with those obtained in the control group. The examined group consisted of 73 children born from single pregnancies in hospitals from families living in Wola district of Warsaw. Out of 73 children, 35 were born t term as small-for-date children (DW). Remaining 38 children were prematurely born (W). The control group (K) consisted of 40 children born in hospital at term, from single pregnancy, with body-weight at birth corresponding to foetal age (25-75 centiles). They came also from families living in Wola district. Analysis of physical development was based on the results of anthropometric measurements carried out at monthly intervals through the first year of life, considering required age tolerance, using standardized measuring methods and instruments. The principles of feeding, nursing, prophylaxis of rickets and iron deficiency as well as preventive vaccinations were the same for all children. Variability with age as well as monthly and yearly gains and the index of sexual dimorphism of the following parameters were analysed: body-weight, body-length, head and chest circumference thorax and head length, shoulders width, hip width. Longitudinal observation of these children through evaluation of growth increments made the analysis of the dynamics of somatic development possible. The analysis showed differences in physical development in the first year of life in children under examination. These differences concerned both the variability of separate traits with age, and the dynamics of development, development of sexual dimorphism index in relation to the control group. The differences ere also observed between the small-to-date and prematurely born children. Developmental differences ere noted among the children born with low body-weight dependent on the achieved foetal age at birth. No tendency in small-for-date infants to decrease the differences as compared to the control group was noted. This tendency was typical of the prematurely born children. The highest developmental rate was observed in prematurely born infants.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:[Longitudinal studies on the physical development of low birth weight children. Growth dynamics and sexual dimorphism during the first year of life]. 26 35

Levels of erythrocyte delta-aminolevulinate dehydratase [ALA-dehydratase; porphobilinogen synthase; 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing), EC 4.2.1.24], UROPORPHYRINOGEN-I synthase [Uro-synthase; porphobilinogen ammonia-lyase (polymerizing), EC 4.3;1.8], AND PROTOPORPHYRIN IX (Proto) were measured by sensitive semimicroassays using 2-5 mul of whole blood obtained from normal and anemic mutant mice. The levels of erythrocyte ALA-dehydratase and Uro-synthase showed marked developmental changes and ALA-dehydratase was influenced by the Lv gene. Mice with overt hemolytic diseases (ja/ja, sph/sph, nb/nb, ha/ha) had 10- to 20-fold increases in ALA-dehydratase, Uro-synthase, and Proto compared with their normal controls. Mice with an iron deficiency (mk/mk) and mice with hypoplastic anemias (W/Wv, Sl/Sld, an/an) had mild to moderate increases in these parameters. Elevated enzyme activities and Proto correlated well with the number of reticulocytes. Because all mice with anemias possessed elevated levels of ALA-dehydratase, Uro-synthase, and Proto independent of differences in their genotypes, the increase in these parameters is not likely to be the result of a specific gene defect. The increased enzyme activities and Proto concentration probably reflect increased frequency of young red cells that are still active in heme biosynthesis.
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PMID:Levels of delta-aminolevulinate dehydratase, uroporphyrinogen-I synthase, and protoporphyrin IX in erythrocytes from anemic mutant mice. 26 62

One-third of a group of young children admitted to hospital had levels of ascorbic acid indicative of a deficiency state. The average haemoglobin of these children was 91g/1, and there was also evidence of iron deficiency.
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PMID:The leucocyte ascorbic acid levels of children in hospital. 26 52

The metabolism of iron-poly (sorbitol-gluconic acid) complex (Ferastral) was studied in 6 blood donors with latent iron deficiency and 13 patients with manifest iron deficiency anaemia. Between 125 and 1 000 mg of iron were injected. In latent deficiency an average of 19% of the dose given was excreted during the first two weeks. The corresponding figure for patients with manifest iron deficiency was 11%. An average of 8% of the dose was retained at the site of injection after 40 days. In the two groups, respectively, 61% (range 47%-70%) and 58% (range 24%-86%) of the iron retained was incorporated into red cells after 40 days, which is judged to be quite satisfactory. Some local side effects were observed.
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PMID:Metabolic studies of iron-poly (sorbitol-gluconic acid) complex, Ferastral. 27 25

This paper is a progress report on our present understanding of iron nutrition in man, particularly in developing countries. We will be concerned with the quantitative aspects of iron balance and in particular with the availability of dietary iron, the recognition of iron deficiency and its prevalence, the effects of iron deficiency on the well being of the individual, and the feasibility of modifying the iron balance of man by dietary means.
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PMID:Iron nutrition. 27 70


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