Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0240066 (iron deficiency)
 7,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Therapy with recombinant human erythropoietin (rEPO) can correct anemia in RDT patients. However, iron deficiency can develop making treatment unsuccessful. Eighteen non-transfused RDT patients with hematocrit less than 26% were treated with rEPO to raise the HCT to 30-35%; then the dose was individually adjusted to maintain the HCT. The mean HCT rose from 22.3% to 31.5%. Ten patients received iron substitution before rEPO. During rEPO therapy five further patients had to be supplemented with iron; all patients needed an increase in the oral iron doses and three required i.v. iron. During the correction phase mean serum ferritin dropped from 203 micrograms/l to a minimum of 71 micrograms/l and was 102 micrograms/l after six months. Serum iron and TIBC changed only moderately. It thus appears that iron demand rises markedly during rEPO therapy, requiring iron substitution in most patients. Serum ferritin is the most sensitive parameter for development of iron deficiency.
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PMID:Iron metabolism under rEPO therapy in patients on maintenance hemodialysis. 234 53

Studies of ferrokinetics, iron status and serum erythropoietin levels were undertaken in 28 Asian patients on RDT as they appeared to be more anaemic and to have a poorer response to treatment than their Western counterparts. The main aetiological factor seemed to be inadequate bone marrow function which tended to be worst in those who had been on dialysis the longest. In addition it is possible that there was also a relative lack of erythropoietin. Dietary factors and iron deficiency were not important. The possible roles of a progressive accumulation of a toxic factor, or of relative underdialysis in patients who were profoundly uraemic prior to the institution of regular haemodialysis, are discussed.
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PMID:Studies on the anaemia of Asian patients with chronic renal failure undergoing regular haemodialysis. 707 23