Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0240066 (iron deficiency)
 7,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The presence of anaemia and serum protein alteration frequently makes the treatment of pressure ulcers more difficult. Several haemato-chemical parameters were observed in 40 patients with sacral pressure ulcers in order to determine the pathogenesis of these complications. All of the patients showed mild-moderate anaemia with low serum iron and normal or increased ferritin and hypoproteinemia with hypoalbuminemia. Our results suggest that both anaemia and serum protein alteration depend on the chronic inflammatory state due to the presence of pressure ulcers. Both anaemia and hypoproteinemia disappeared after pressure ulcer healing. A correct diagnosis is important for the treatment. Iron therapy is useless and potentially dangerous (iatrogenic haemochromatosis) since anaemia is the result of the inability to use iron stores and not iron deficiency. The treatment of serum protein alterations should be based on a dietary therapy rich in protein and calories; the administration of albumin should be reduced, since albumin is low in essential amino-acids and too expensive; albumin administration should be limited to cases with severe hypoproteinemia and oedema.
Spinal Cord 1997 Jan
PMID:Anaemia and serum protein alteration in patients with pressure ulcers. 902 23

Restless legs syndrome (RLS) is characterized by discomfort and paresthesias in the legs with urge to move the legs, worsening of the symptoms with the rest or inactivity, present or exacerbation in the evening or night and partial or total relief with movement. The diagnosis is primarily clinical. RLS is idiopathic, with family history in 40-60% of the cases, or symptomatic associated conditions such as iron deficiency, uremia, pregnancy, Parkinson's disease, neuropathy or myelopathy. Although the pathophysiology of RLS remains unknown, it has been implicated a central dopaminergic dysfunction. In the last years it has increased the interest and has been published several papers about RLS, that make significant contributions to the current understanding of the syndrome. The aim of this paper is to review the cur-rent advances in the field of RLS, with special emphasis on symptomatic causes of the syndrome, from both epidemiological and pathophysiological points of view.
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PMID:[Symptomatic causes of restless legs syndrome.]. 2034 60