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Query: UMLS:C0240066 (iron deficiency)
 7,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Anthropometric measurements of alcoholics and non alcoholics of similar economic background were compared and the results reveal that there are no marked differences between the two. However, the biochemical analyses indicates that alcohol predisposes to fat storage, may contribute to iron deficiency and plays a direct etiologic role in liver disease.
West Afr J Med
PMID:Assessment of anthropometric measurements, blood analytes and liver enzymes in Ghanaian alcoholics. 130 90

Hypochromic anaemia is very common among the island populations of Vanuatu in the South-West Pacific. Results of a large-scale survey show that, unexpectedly, this form of anaemia is seldom due to iron deficiency or coexistent parasitic disease. Rather, it results from a previously unsuspected high incidence of alpha-thalassaemia which has been identified only by application of DNA analysis to the populations studied. These findings suggest that hypochromic anaemia in tropical or subtropical populations should not necessarily be attributed to iron deficiency; detailed studies of iron status should be carried out before major dietary changes or fortification of food with iron are implemented.
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PMID:Relative roles of genetic factors, dietary deficiency, and infection in anaemia in Vanuatu, South-West Pacific. 286 13

Plasma ferritin is a secretory component of intracellular ferritin synthesis. In normal persons its amount reflects the size of iron stores. A decrease to less than 12 mug per liter indicates iron deficiency. Increased iron stores are associated with an increased plasma ferritin level. Various other conditions, however, can increase the plasma ferritin concentration including increased metabolism, inflammation, tissue damage and neoplastic disease. The use of the plasma ferritin determination in diagnosing iron overload depends on excluding these other causes, leaving storage iron as the only explanation for the increased plasma ferritin. It is then necessary to establish the parenchymal nature of the iron overload by showing an elevated transferrin saturation and, if elevated, the more definitive liver biopsy should be done.
West J Med 1986 Nov
PMID:Plasma ferritin determination as a diagnostic tool. 354 87

The laboratory evaluation of anemia begins with a complete blood count and reticulocyte count. The anemia is then categorized as microcytic, macrocytic or normocytic, with or without reticulocytosis. Examination of the peripheral smear and a small number of specific tests confirm the diagnosis. The serum iron level, total iron-binding capacity, serum ferritin level and hemoglobin electrophoresis generally separate the microcytic anemias. The erythrocyte size-distribution width may be particularly helpful in distinguishing iron deficiency from thalassemia minor. Significant changes have occurred in the laboratory evaluation of macrocytic anemia, and a new syndrome of nitrous oxide-induced megaloblastosis and neurologic dysfunction has been recognized. A suggested approach to the hemolytic anemias includes using the micro-Coombs' test and ektacytometry. Finally, a number of causes have been identified for normocytic anemia without reticulocytosis, including normocytic megaloblastic anemia and the acquired immunodeficiency syndrome.
West J Med 1987 Apr
PMID:Laboratory evaluation of anemia. 357 35

Research was conducted in Liberia, West Africa to ascertain which hematinics produce the best Hb response in women during the 3rd trimester of pregnancy. After obtaining background information, each of the 621 subjects was randomly assigned to one of four treatment groups. Group 1 was given 60 mg iron once daily, group 2 was given 60 mg iron 3 times daily, group 3 was given 60 mg iron 3 times daily plus a 5-mg folic acid tablet once daily, and group 4 was given the same treatment as group 3 but also a weekly antimalarial prophylactic. For comparison, 58 untreated women in their 3rd trimester were also studied. Before therapy the five groups were similar with respect to selected socioeconomic status, health, and dietary variables. Hb response to therapy was measured at 4-wk intervals from the 24th wk of gestation until term. The Hb rises in all four treatment groups were significantly (p less than 0.001) higher than the base-line values at 4, 8, and 12 wk after the interventions. The percentage of anemic women was reduced from 78 to 45% over the 12 wk of supplementation. Hb rises in groups 3 and 4 were not significantly different from those in groups receiving iron alone. It is concluded that iron deficiency is the main cause of anemia in this population.
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PMID:Anemia of pregnancy in Liberia, West Africa: a therapeutic trial. 707 24

Mild iron deficiency is common among infants, adolescents and women during the childbearing years. Practical and economical approaches toward its identification, treatment and prevention are needed. Laboratory screening is based on hemoglobin or hematocrit determinations compared with age-specific and sex-specific reference standards. If blood specimens have been analyzed by electronic counter, the presence of a normal or low-normal value for red cell volume increases the likelihood that anemia is due to iron deficiency. Other laboratory tests that may be helpful in selected cases include determining serum ferritin, transferrin saturation or erythrocyte protoporphyrin values. However, in most cases, a simple therapeutic trial with ferrous sulfate may be instituted on the basis of history and a screening test alone. If repeat laboratory studies after a month show no improvement, iron treatment should be stopped and other causes of anemia should be considered.
West J Med 1981 Jun
PMID:Iron deficiency: diagnosis and treatment. 725 64

Nutritional anaemia, thought to be caused by iron deficiency, affects 50-70% of pregnant women in the developing world. The influence of vitamin A and iron supplementation was studied in anaemic pregnant women in West Java, in a randomised, double-masked, placebo-controlled field trial. 251 women aged 17-35 years, parity 0-4, gestation 16-24 weeks, and haemoglobin between 80 and 109 g/L were randomly allocated to four groups: vitamin A (2.4 mg retinol) and placebo iron tablets; iron (60 mg elemental iron) and placebo vitamin A; vitamin A and iron; or both placebos, all daily for 8 weeks. Maximum haemoglobin was achieved with both vitamin A and iron supplementation (12.78 g/L, 95% Cl 10.86 to 14.70), with one-third of the response attributable to vitamin A (3.68 g/L, 2.03 to 5.33) and two-thirds to iron (7.71 g/L, 5.97 to 9.45). After supplementation, the proportion of women who became non-anaemic was 35% in the vitamin-A-supplemented group, 68% in the iron-supplemented group, 97% in the group supplemented with both, and 16% in the placebo group. Improvement in vitamin A status may contribute to the control of anaemic pregnant women.
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PMID:Supplementation with vitamin A and iron for nutritional anaemia in pregnant women in West Java, Indonesia. 790 29

The authors investigated the effect of weekly iron supplementation with and without deworming upon hemoglobin in a double-blind, placebo-controlled field trial conducted in the West Javanese village of Setia Asih. 289 children aged 2-5 years were randomly divided into three equal-sized treatment groups for the study. Groups one and two received 30 mg iron once weekly, while group three received a placebo. Group one also received anthelminthic treatment. Supplements were administered by the mothers who were taught about iron deficiency beforehand. In the iron-supplemented groups, the prevalence of anemia decreased from 37.2% to 16.2% and hemoglobin increased by an average of 6.9 +or- 9.8 g/l. However, hemoglobin increased only 1.9 +or- 8.0 g/l in the placebo group. No subjects had hookworms, so anthelminthic treatment had no additional effect.
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PMID:Effective community intervention to improve hemoglobin status in preschoolers receiving once-weekly iron supplementation. 909 93

We undertook this study to determine if culturally influenced feeding practices are associated with iron deficiency in infants and toddlers from low-income families. We obtained a dietary survey, illness history, hematocrit, and zinc protoporphyrin-to-heme ratio (ZPP/H) from 35 Southeast Asian children and 73 children of other ethnicities between ages 5 and 30 months. We confirmed iron deficiency by serum ferritin measurement in children with ZPP/H > 80 mmol/mol or evaluated them after a 3-month iron treatment. Sixty percent of the Southeast Asian children had elevated ZPP/H ratios, compared with 14% of children of other ethnicities. Follow-up studies confirmed iron deficiency in 12 of 21 Southeast Asian children with elevated ZPP/H; 75% (eight) of those with confirmed iron deficiency were 24 to 30 months of age. We found that toddler feeding practices differ between Southeast Asians and other ethnic groups. All 17 Southeast Asian toddlers were still bottle fed at their second birthday, compared with 10 of 21 same-age children of other ethnicities. Persistence of bottle feeding after 2 years of age was highly associated with elevation of ZPP/H in Southeast Asian children but not in other children. Clinicians need to be aware of this problem and carefully monitor iron status in children not weaned from the baby bottle by age 2 years. Changes in education practices and policies are needed to prevent iron deficiency from the overintake of cow's milk that results from prolonged bottle feedings in this ethnic group.
West J Med 1997 Jul
PMID:Delayed bottle weaning and iron deficiency in southeast Asian toddlers. 926 57

Algorithms for the differential diagnosis of anemias are commonly based on suspected incidences and simple laboratory parameters. Especially microcytic anemias are diagnosed using algorithms created in Mediterranean or Northern American regions. In a West German region we observe relatively high diagnostic uncertainty regarding common forms of anemias. As a hypothesis, this may be a result of inadequate algorithms not designed for regions with high incidences of anemias of chronic disease and low incidences of thalassemias. To further elucidate diagnostic problems we here report the frequencies of anemias in university hospital outpatients. Based on these data, the diagnostic values of different erythrocyte indices and of red cell distribution width in the differential diagnosis of anemias were calculated. 4525 patient files were reviewed retrospectively. 872 patients presented with anemia, 107 of which were hereditary forms and 765 of other forms. In hereditary anemias the frequency of thalassaemias (50 patients) and corpuscular hemolytic anemias (49 patients) was the same. Nearly half of the other anemias were covered by anemias of chronic disease and true iron deficiency anemias. Several indices intended to separate thalassemias from other microcytic anemias were tested for relevance. Sensitivity was between 0.75 and 0.85. Specificity was between 0.78 and 0.95. Red cell distribution width was not significantly different between thalassemias and iron deficiency. Only a red cell distribution width above 17.0 resulted in a specificity for iron deficiency of 0.91. Red cell distribution width is considered to be an unreliable screening test in a population with a low incidence of thalassemias. The high incidence of anemias of chronic disease in the region investigated should lead to more complex diagnostic procedures than offered by blood count values alone.
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PMID:Erythrocyte indices as screening tests for the differentiation of microcytic anemias. 939 91


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