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Query: UMLS:C0240066 (iron deficiency)
 7,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Absolute or functional iron deficiency decreases the effectiveness of erythropoietin in patients undergoing hemodialysis. We describe a patient who developed pica associated to a ferritin level of 800 ng/ml during recombinant human erythropoietin treatment. The symptom subsided after supplementation with iron dextran. Therefore we recommend iron supplementation during the initial phase of treatment with erythropoietin until serum ferritin levels raise above 1000 ng/ml.
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PMID:[Reappearance of pica symptoms during erythropoietin treatment]. 134 83

Iron deficiency, the most common cause of anemia, is prevalent in 10 percent to 30 percent of the world's population. Inadequate intake of iron may be an important causative factor, particularly when the body requires more iron than usual (e.g., during infancy, early childhood, adolescence, pregnancy and periods of blood loss). The popular increase of fiber in diets may increase the incidence of iron-deficiency anemia because too much fiber in the diet renders available iron unabsorbable. Symptoms in children include skin or conjunctival pallor, excessive sleepiness, learning disabilities, diminished attention span, tiredness, irritability or inappropriate behavior, and pica. Adults may have shortness of breath, decrease in exercise tolerance, palpitations, tachycardia, angina, congestive heart failure, orthopnea and edema. Iron deficiency occurs in sequential states and is measured by many laboratory tests. The levels of hemoglobin and hematocrit are both decreased, while the red blood cell count may be normal initially, but will decrease as the iron-deficiency state continues. The steps of treatment include correction of the underlying disorder, administration of the amount of iron needed and observation of the response to treatment.
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PMID:A guide to primary care of iron-deficiency anemia. 143 77

Deficiency of nutritional iron represents a public health problem recognized throughout much of the world. The overall prevalence rate of patients with iron deficiency (ID) who need supplementary iron therapy ranges markedly from less than 10% to as high as 70% among various ethnic and socioeconomic groups. Dermatologically, the iron-deficit state can be a secondary condition or trigger a wide range of mucocutaneous alterations. Early appreciation of adverse cutaneous manifestations of ID seems to have commensurate significance not only in predicting the presence of undiagnosed ID, but also for providing specified avenues for rational therapeutic approaches to patients with ID. Dermatopathic anemia has attracted the attention of clinicians because ID was found to be a metabolic consequence of skin diseases such as erythroderma, exfoliative dermatitis, psoriasis, eczema, and many others. Previous studies had suggested that iron may be lost in accelerated turnover of the keratinocyte from scaling; currently, malabsorption of iron is accepted implication accounting for dermatopathic anemia. However, mucocutaneous affections adversely manifested by ID have not been extensively reviewed and published in the current dermatologic literature because of the potentially benign course of the adverse conditions and the limited degree of clinical expression. Therefore, changes in hair, nails, mucosa and tongue, pruritus, chronically sustained inflammation, dermatitis herpetiformis, and photodermatitis are among the adverse cutaneous sequelae whose relation to ID are highlighted and discussed in the present review. Because of their clinical and diagnostic importance, other extracutaneous physical signs of ID, such as blue sclerae and pica, are also included in this review.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Iron deficiency: structural and microchemical changes in hair, nails, and skin. 176 60

Persistent pica may be either a cause or a result of iron deficiency. Three children are described with long-standing pica and iron-deficiency anemia and in whom total villous atrophy consistent with celiac disease was found on jejunal biopsy. Additional findings included short stature, delayed bone age, and impaired xylose absorption. A dramatic growth spurt and complete resolution of pica were observed after a gluten-free diet. In these cases pica evidently resulted from iron deficiency secondary to malabsorption. Underlying celiac disease should be considered in children with persistent pica and growth failure even if gastrointestinal disturbances are minimal.
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PMID:Pica as a presenting symptom in childhood celiac disease. 230 99

We present 2 patients with carotenemia who also suffered from iron deficiency anemia. A causal relationship between the ingestion of excessive quantities of carrots and iron deficiency is postulated, since iron deficiency is known to be responsible for change of appetite (pica). A knowledge of this condition, which follows an indolent, reversible course, is necessary for the clinician mainly in view of the differential diagnostic aspects.
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PMID:[Icterus due to carotene associated with iron deficiency anemia]. 275 8

Pica was a surprise finding in 8 cases of severe iron deficiency anaemia of unknown cause and 2 patients with pregnancy-related anaemia who had a mixed picture of iron deficiency and megaloblastic features owing to folic acid deficiency. The pica cases demonstrated an apparently consistent pattern: severe anaemia, young age, normal psychiatric assessment, good nutrition and lack of an overtly disadvantaged background. Pica was significantly absent in other forms of anaemia in a series of 53 subjects. The literature is briefly reviewed to highlight the unanswered questions about this disorder. The cases reported do not furnish any clues to the enigma of pica, but reveal an obscure form of idiopathic iron deficiency anaemia. Pica may be commoner than is thought.
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PMID:Iron deficiency anaemia and pica. 377 86

A young woman was referred for nephrologic evaluation of hypertension and a curious desire for table salt. Suspicion of iron-deficiency anemia arose only after it was determined that sodium balance was achievable during supervised sodium restriction. This salt craving abated within 2 weeks of initiation of iron replacement therapy. Although pica is a common manifestation of iron deficiency, this appears to be the first reported case of salt pica secondary to iron deficiency.
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PMID:Sodium chloride pica secondary to iron-deficiency anemia. 396 72

Erythrocyte protoporphyrin levels are high in lead poisoning, iron deficiency and erythropoietic porphyria. On-site fluorometric assay was used to screen for raised blood levels in three groups of children in one city: 166 who were severely mentally retarded and lived in an institution, 88 who were moderately to severely mentally retarded and attending special schools but lived at home, and 128 who were of normal intelligence and attended a regular school. High erythrocyte protoporphyrin levels (40 micrograms/dl [0.7 mumol/l] or greater) were found in 14 of the children, each of whom was tested for further evidence of lead poisoning and iron deficiency. The two children found to have high blood lead levels (above 30 micrograms/dl [1.5 mumol/l]) were both living in the institution, were ambulatory and had pica. Of the other 12 children 8 had evidence of iron deficiency, though in 4 the probability of a true deficiency was low. The fluorometric assay of erythrocyte protoporphyrin may prove to be a simple method of screening for lead poisoning and iron deficiency.
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PMID:Fluorometric assay of erythrocyte protoporphyrin: simple screening test for lead poisoning and iron deficiency. 713 5

A patient with lung cancer treated by radiation and in remission presented with a two-month history of compulsive eating of raw, chilled potatoes. Suspicion of a pica due to iron-deficiency anemia was confirmed after complete laboratory evaluation. The source of iron loss was found to be gastrointestinal bleeding. Therapy with iron sulfate was begun, with a subsequent increase in the hemoglobin level; the pica ceased within one week of initiation of therapy. If searched for, pica is a common manifestation of iron deficiency; however, this patient apparently represents the first report of geomelophagia. Appropriate investigation of compulsive eating habits might lead to the diagnosis of iron deficiency and also allay patients' anxieties toward their behavior.
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PMID:Geomelophagia. An unusual pica in iron-deficiency anemia. 714 84

We describe two new forms of pica associated with iron deficiency and a new variant of a third. Previous reports on pica are tabulated. The value of a sympathetic, nonjudgmental approach to eliciting the medical history is emphasized.
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PMID:Pica, iron deficiency, and the medical history. 794 44


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