Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0240066 (
iron deficiency
)
7,156
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Iron deficiency
has far reaching consequences on systemic functions apart from the well known feature of anemia. Because iron deficiency anemia is easy to recognize and treat, the non-hematological manifestations of this trace element deficiency have been overlooked. There is a large body of evidence accumulated from animal and human studies to indicate that
iron deficiency
states are associated with alterations in cellular function, growth, motor development, behaviour and cognitive function. There are consequences for the host's level of immunocompetence against infection, for physical work and metabolic stress, for altered fetal outcome and
premature labour
in pregnant women. The gastrointestinal functions and other organ systems are also affected as a result of
iron deficiency
. The purpose of this review is to emphasize the importance of the non-hematological manifestations of
iron deficiency
and to highlight areas of interest, both to basic scientists and health care professionals.
...
PMID:Iron deficiency; non-hematological manifestations. 178 38
In general, the diagnosis of pregnancy-related anemia relies on the estimation of the hemoglobin level. The findings of this study suggest that the additional estimation of serum ferritin - a reliable index of the iron stores - can improve the diagnosis of anemia. Hematological data of 150 pregnant women were retrospectively related to the courses of pregnancy, in particular to the incidence of
premature labor
contractions. 70% of the pregnant women included in the investigation had a serum ferritin value below 20 micrograms/l and thus
iron deficiency
. If the hemoglobin value alone had been estimated, 50.6% of the women with
iron deficiency
(serum ferritin less than 20 micrograms/l) would not have been detected among those pregnant women with a hemoglobin value of more than 11 g/dl. These findings are also of particular relevance as a significant correlation has been found between the incidence of
premature labor
contractions and the serum ferritin level: only 11% of the pregnant women investigated whose serum ferritin values exceeded 20 micrograms/l had
premature labor
contractions, whereas
premature labor
was recorded in 48% of the pregnant women with serum ferritin values below 10 micrograms/l.
...
PMID:Premature labor contractions and the value of serum ferritin during pregnancy. 322 62
