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Query: UMLS:C0240066 (iron deficiency)
 7,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Iron deficiency in active men is well documented. To assess the relative importance of dietary iron intake, iron absorption, and iron loss in the pathogenesis of this iron deficiency, we compared a group of iron-deficient athletes to a group with normal iron stores. Iron absorption was assessed by an iron tolerance test. Serum haptoglobin was used as a measure of hemolysis. The presence of hemoglobinuria reflected urinary iron loss. Iron intake was determined by a 3-day dietary record as well as a food frequency questionnaire. Results showed iron absorption to be inversely correlated with iron stores. Iron-deficient athletes had higher absorption, suggesting a normal regulation mechanism. Major hemolysis (serum haptoglobin below 40 mg/dl) was found in 28% of subjects with no relationship to iron stores. No hemoglobinuria was detected after a usual training session. Iron intake was elevated in relation to high caloric intake, but iron intake in the form of meat was lower in iron-deficient athletes, as compared to those with normal or repleted iron stores. It is our opinion that inadequate iron intake is an important determinant of iron deficiency in athletes.
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PMID:Iron deficiency among active men. 276 Mar 51

We report the hematologic and clinical features of four adult patients (Pts.) with sickle cell anemia and iron-limited erythropoiesis. Two of the Pts. had spontaneous iron deficiency (chronic GI bleeding, low-grade hemoglobinuria). In the other two Pts. iron restriction was induced by periodic RBC aphereses as part of a pilot protocol designed to decrease intracellular HbS polymerization by MCHC reduction. Iron-limited erythropoiesis was defined by reduction in red cell indices (MCV range 60.4-67 fl) in the presence of low serum ferritin (range < 10-20 ng/ml). In these Pts. iron restriction did not cause clinically significant worsening of the anemia (Hb 7.8-9.0 g/dl). In two Pts. the anemia actually improved. Other hematologic effects of iron restriction were: decreased MCHC, reticulocyte count, RDW, and dense cells. A reduced hemolytic rate was suggested by a lowering of serum bilirubin and LDH. In one of the Pts. the 51Cr RBC T1/2 survival increased from 12 to 16 days. The intracellular HbS polymer fractions (fp) were determined at 25% O2 by Csat and with the use of the conservation of mass equation. The baseline fp values ranged from 0.48-0.53. After iron restriction they ranged from 0.33-0.48. The fp decreased even though iron-limited erythropoiesis also lowered the Hb F concentration in three of our Pts. In one of the two Pts. with induced iron depletion, hospitalization days for pain crises decreased from an average of 4.5 days/month (2 year baseline period) to an average of 0.5 days/month in the 3 year follow-up after iron depletion. The second patient with induced iron restriction experienced the rapid healing of a leg ulcer. Controlled iron restriction should be explored as a therapeutic strategy in selected SS patients.
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PMID:Improvement of sickle cell anemia by iron-limited erythropoiesis. 766 35

This paper discusses a case study of a 19-year-old male student who engaged in daily long distance running and presented with complaints of fatigue and dizziness. Laboratory test revealed a hemoglobin of 7.7 g/dl and a bone marrow negative for iron. After a complete evaluation no source of blood loss was identified. His iron deficient state may be caused by his exposure to long distance running for some years. Recent work from Sweden reports iron deficiency in eight runners, demonstrated by bone marrow examination. Further work in West Germany shows low ferritin values in runners. Source of iron loss may be from hemoglobinuria and/or excessive sweating. Hemoglobin and ferritin values should be monitored in runners every six to 12 months.
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PMID:Iron deficiency anemia in a distance runner. 2128 10