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Query: UMLS:C0240066 (iron deficiency)
 7,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to determine the nutritional adequacy of diets MIT 200 and NIH 2000 on the growth and development of experimental animals, these two diets were fed to two groups of animals during three periods of development: 1) pregnancy; 2) lactation, and 3) post-weaning. These diets were compared with a diet that satisfied the requirements of the National Research Council for growth and maintenance. It was found that for the two experimental diets, growth was compromised due to a caloric deficit in both diets. In addition, NIH 2000 was deficient in other nutrients such as iron. Analysis of other parameters such as hemoglobin, hematocrit, salivary protein, saliva flow and weight of vital organs upon autopsy revealed a picture of iron deficiency in the NIH 2000 group. Caries formation can be precipitated by a mechanism influenced by a nutrient deficit.
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PMID:Growth, development and dental caries in rats fed two experimental diets. 667 70

Nutritional surveys attempt to estimate the nutritional status of people from various physical (clinical, anthropometric) and biochemical (with respect to nutrients) measurements, whereas dietary surveys attempt to measure what people eat. Although dietary surveys help explain possible reasons for clinical and laboratory findings, the nutritional status of people cannot be inferred from the diet alone. The determinants of nutritional status and, for that matter, the health of the individual and the population as a whole, include a variety of factors, biologic (genetic), behavioral, sociocultural, economic, and environmental. Diet is one environmental factor of great importance in determining man's level of health and well-being. The 1971-1974 HANES showed that excessive weight or obesity is a major health problem affecting people at all age and economic levels. At the same time, the survey showed a trend toward low calorie intake among certain adults over age 45, particularly women over age 60. The data also indicate that iron deficiency occurs among young children, pregnant women, and the elderly and that dental caries is a prevalent condition. Vitamin and iodine deficiencies, for practical purposes, do not exist in the U.S. population, although several surveys have uncovered certain vitamin deficiencies among the elderly. Dietary deficiencies, where they occur, are related to socioeconomic and cultural factors, specific conditions, and disease states. Reliable data do not exist to estimate the extent of malnutrition among the hospitalized and institutionalized population.
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PMID:Overview of nutritional status in the United States. 730 53

Since the Nutrition Canada Survey (1973) there has been clear evidence that Aboriginal people have low intakes of many nutrients such as iron, vitamin D, calcium, folate, vitamin A, and fluoride. Recent surveys suggest that the situation has not changed. Children are most likely to be affected clinically. More than half of Aboriginal children in some subpopulations in Manitoba suffer a period of iron deficiency, which may affect development. Nutritional rickets is still a common problem in Manitoba. We have seen cases of megaloblastic anemia due to folate deficiency. The relationship of the well-described low folate intake in pregnancy and birth defects has received no attention for the Aboriginal population. In a recent survey of Inuit children, dental caries of the primary teeth were present in over 70% of children, with a mean DMF (decayed, missing, and filled) index of 1.8 teeth in children under 2 and 9.5 in children 6 to 8 years. Although clinical vitamin A deficiency is not seen, there is now good evidence that subclinical deficiency increases susceptibility to infections. Although not all Aboriginal populations suffer all of these deficiencies, the problems are sufficiently widespread to suggest this is an urgent problem. It will not be solved simply by education. There must be a political will and a coordinated effort to make a balanced diet available to all at an affordable cost.
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PMID:Current status of nutritional deficiencies in Canadian aboriginal people. 758 49

World Health Organization (WHO) estimates that 2.5 billion people have anemia caused by iron deficiency that could be prevented by fortification of food; sugar, for example, has been used successfully as a vehicle for dietary iron fortification. The inclusion of 88 ppm of iron (as FeSO4) co-crystallized with sugar has been shown to reduce the incidence of caries by more than 30% when rats are fed 17 meals daily at hourly intervals. The purpose of the present study was to determine the influence of varying the number of daily exposures to iron on caries in desalivated rats. Four litters of 12 Sprague-Dawley rats were desalivated when aged 25 days and caged in a programmed feeder. All animals received their essential nutrition by gavage and 17 meals of sucrose daily. In Group A, 6 meals contained 88 ppm Fe; in Group B, 3 meals continued iron: Group C had 2 meals, and in Group D, no iron was added. The investigation continued for 3 weeks. Smooth-surface and sulcal (in parentheses) caries scores were: Group A 60.8 (39.4); Group B 72.4 (41.3); Group C 73.1 (41.3), and Group D 92.9 (49.2). Caries scores in all the iron groups were statistically lower than in the control group. Severity scores followed a similar pattern. Thus, as few as 2 daily exposures to iron-sucrose had a significant effect on caries development; therefore the use of iron as a cariostatic agent is worthy of further exploration. The concept that two major public health problems could be alleviated by the addition of iron to sucrose is indeed attractive.
Caries Res 1997
PMID:Effects of frequency of exposure to iron-sucrose on the incidence of dental caries in desalivated rats. 916 97

Anaemia caused by iron deficiency and dental caries are still among the most prevalent diseases in some developing countries. Anaemia can be prevented by iron fortification of food. Previous studies demonstrated that iron-sucrose, which has been used for prevention of anaemia, reduces the incidence of caries in rats. The aim of the present study was to compare the influence of ferrous sulphate and ferric glycerophosphate co-crystallized with sucrose on the incidence of dental caries in rats. Forty-eight desalivated rats were caged in a programmed feeder and received their essential nutrition by gavage. The animals were fed 17 meals per day at hourly intervals of 88 parts/10(6) Fe++ or Fe co-crystallized with sucrose. Plain sucrose and calcium glycerophosphate with sucrose were used as control groups. Both ferric- and ferrous-sucrose meals reduced the incidence of smooth-surface and sulcal caries in rats. Stain formation, organic acid production and acidogenic activity of dental plaque in animals receiving iron-sucrose meals were also investigated. Ferric glycerophosphate did not induce extrinsic staining on the tooth surface. The concentration of organic acids did not differ significantly among the groups. The acidogenic activity of plaque in animals receiving either of the iron-sucrose meals tended to be lower than that of the control groups. The possibility that iron-sucrose might reduce the prevalence of two major public health problems, dental caries and anaemia, makes this preventive approach extremely attractive for additional investigation.
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PMID:Effects of iron salts in sucrose on dental caries and plaque in rats. 923 47

For more than three decades, it has been recognized that dental caries is an infectious and transmissible disease in which diet plays a key role. Nevertheless, in treating patients with early childhood caries, scant attention is placed on exploring the source of infection and the prevalence of caries in other family members. Results from studies conducted in animals clearly show that the virulence of mutans streptococci can be enhanced by a highly cariogenic environment. For example, offspring from a highly caries-active dam develop significantly more caries than pups from a low caries-active dam. Considerable attention has been placed on the role of the nursing bottle in early childhood caries. Milk and some infant formulas do not promote caries and the role of the remainder of the diet has been largely ignored. The nursing bottle can effectively block salivary access to tooth surfaces, thereby increasing the cariogenicity of any food remaining in the mouth. Recent evidence shows that salivary gland function is impaired by iron deficiency and by prenatal exposure to lead. Clearly, early childhood caries is a complex disease that requires careful and extensive investigation.
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PMID:Response to Seow: biological mechanisms of early childhood caries. 967 Nov 96

Micronutrient deficiency is a serious public health concern in most developing countries. In India, iron deficiency, vitamin A deficiency, and iodine deficiency disorder are of greatest public health significance. In addition, subclinical zinc deficiency, flourosis, and fluoride-deficient dental caries are important areas of concern. The National Pilot Program on Control of Micronutrient Malnutrition was launched in 1995 to address these problems and the Department of Biochemistry and Nutrition of the All India Institute of Hygiene and Public Health (Calcutta) was entrusted to coordinate its activities. The program presently covers one northeastern and four eastern states, namely Assam, Bihar (Jharkhand), Orissa, West Bengal, and Tripura. Baseline analyses were conducted on demographic situation, food and nutrient intake pattern, nutritional deficiency diseases (e.g., iron deficiency anemia), iodine deficiency disorder, and vitamin A deficiency. It was observed that except for cereals, the diet was deficient in all other food groups. Nutrient intake (i.e., energy, protein, vitamins, and minerals) was also deficient in almost the entire state. Anthropometric indices (e.g., weight-for-age and height-for-age data) indicated that large percentages of <5-year-old and 6-14-year-old children were in grade II or III malnutrition. Mean dietary zinc intakes in all the surveyed districts were much lower than the RDA. Large percentages of salt samples had iodine levels less than 15 ppm. The point prevalence of anemia in various age groups was found to be high. Bitot's spot was mainly noted in the age group of 6-71 months. Nightblindness was noted in young children as well as the children 24-71 months old. High prevalence of nightblindness in pregnant women is a point of concern. Actions needed to control micronutrient deficiencies include: intervention strategies, extensive nutrition and health education through innovative IEC materials to support problem-specific programs, strengthening of various state government programs and the role of NGOs.
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PMID:Prevalence of micronutrient deficiency based on results obtained from the national pilot program on control of micronutrient malnutrition. 1203 59

Nutritional deficiencies are still all too common in Native Canadian women and children. Protein-calorie malnutrition is rare, although the 1972 Nutrition Canada Survey found low intakes of these nutrients in many pregnant Native women, especially among the Inuit, who still have a high (8%) incidence of low-birth-weight infants. Clinically, we still see a great deal of iron deficiency and, although it is less common, of vitamin D-deficiency rickets in infants and toddlers. Breastfeeding rates are 50% or less at six months, and prolonged use of the nursing bottle contributes to iron deficiency and dental caries. Fluoride is not present in the water supply of most Native communities and must be given to combat dental caries, which is rampant in some areas. In adolescents we begin to see signs of overnutrition, with noticeable obesity that is highly prevalent in adults. The ultimate solution to these problems is improved economic circumstances and education. In the meantime, however, physicians treating Native patients must become familiar with the local circumstances.
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PMID:Nutritional problems of native canadian mothers and children. 2124 97

Ferumoxytol is a nanoparticle formulation approved by the U.S. Food and Drug Administration for systemic use to treat iron deficiency. Here, we show that, in addition, ferumoxytol disrupts intractable oral biofilms and prevents tooth decay (dental caries) via intrinsic peroxidase-like activity. Ferumoxytol binds within the biofilm ultrastructure and generates free radicals from hydrogen peroxide (H2O2), causing in situ bacterial death via cell membrane disruption and extracellular polymeric substances matrix degradation. In combination with low concentrations of H2O2, ferumoxytol inhibits biofilm accumulation on natural teeth in a human-derived ex vivo biofilm model, and prevents acid damage of the mineralized tissue. Topical oral treatment with ferumoxytol and H2O2 suppresses the development of dental caries in vivo, preventing the onset of severe tooth decay (cavities) in a rodent model of the disease. Microbiome and histological analyses show no adverse effects on oral microbiota diversity, and gingival and mucosal tissues. Our results reveal a new biomedical application for ferumoxytol as topical treatment of a prevalent and costly biofilm-induced oral disease.
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PMID:Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity. 3006 93