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Query: UMLS:C0240066 (iron deficiency)
 7,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The serum level of erythropoietin was measured in 31 patients with anemia secondary to chronic infection or malignancy and compared with erythropoietin levels in 23 patients with iron-deficiency anemia and 14 patients with primary hematopoietic diseases. Erythropoietin levels varied directly with the degree of anemia in patients with iron deficiency or primary hematopoietic disorders. There was no correlation of erythropoietin and the degree of anemia in patients with chronic infection or malignancy and the erythropoietin levels were significantly lower than in patients with iron deficiency or primary hematopoietic disease and the same degree of anemia. A major factor in the anemia of chronic disorders is a decrease in levels of erythropoietin.
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PMID:Serum level of erythropoietin in anemias associated with chronic infection, malignancy, and primary hematopoietic disease. 510 67

Normal and neoplastic cells have similar needs for iron, but the latter may exhibit altered mechanisms of iron acquisition that permit continued multiplication in host iron-restricted tissues. For example, neoplastic cells may form low molecular weight siderophores as well as increase the number of transferrin binding glycoproteins on their cell surfaces. The hosts attempt to withhold iron from neoplastic cells by preventing the return of the metal to plasma and diverting it to storage, by increasing the synthesis of ferritin to accommodate the added stores, and by surrounding tumor cells with macrophages that can ingest lactoferrin-bound iron, but these mechanisms are often not effective against the iron-accumulating mechanisms of the tumor. Persons or animals with iron overload (via ingestion, inhalation, injection, or pathophysiologic process) tend to be at greater risk than normal hosts in the development of neoplasms. The tumors are often associated with the site(s) of deposition of the metal. In addition to its neoplastic cell nutrient function, excess iron might suppress tumorcidal action of macrophages and interfere with lymphocyte traffic. Severe iron deficiency can interfere with the ability of the host to detoxify potential carcinogens as well as with its ability to activate antitumor lymphocytes.
Nutr Cancer 1983
PMID:Iron in neoplastic disease. 630 39

The effect of iron deficiency on oral carcinogenesis was investigated in 30 young adult male Charles River white rats. In 15 animals, prior to the start of carcinogen treatment, iron deficiency anaemia was produced and subsequently maintained by a combination of low iron diet (12 mg Fe2+ kg-1 diet) and repeated venesection. Fifteen control animals were fed the same diet supplemented with iron to approximately 140 mg FE2+ kg-1 diet. All animals were treated with the carcinogen 0.5% 4-Nitroquinoline-N-oxide in propylene glycol which was painted on the palate 3 times weekly. Animals were killed when tumours were grossly evident. The mean haemoglobin levels at the start of carcinogen applications were 10.1 g dl-1 in the anaemic group and 14.1 g dl-1 in the control group, and at the time of killing were 8.2 g dl-1 in anaemic animals and 13.8 g dl-1 in controls. The incidence of animals developing squamous cell carcinomas was similar in both groups, but tumour development was significantly earlier in iron-deficient animals (mean 183 days) compared to controls (mean 229 days). Iron-deficient animals showed a significantly greater incidence of tongue tumours and control animals showed a significantly greater incidence of palatal tumours.
Br J Cancer 1983 Mar
PMID:The effect of iron deficiency on experimental oral carcinogenesis in the rat. 640 24

While the prevalence of iron deficiency has remained relatively constant, there has been continuing refinement in its laboratory recognition, especially with the recent introduction of serum ferritin and FEP measurements. It is helpful to classify iron deficiency into three stages. Storage iron depletion is identified by marrow examination or serum ferritin, iron deficient erythropoiesis by TS, FEP, or MCV, and iron deficiency anemia by hemoglobin concentration or therapeutic iron trial. Combinations of these measurements have been used in prevalence studies to obtain a quantitative measure of body iron stores. The optimal laboratory approach to diagnosing iron deficiency depends on the clinical setting. In the office or outpatient clinic, iron depletion is best recognized by the serum ferritin, although the TS, FEP, and MCV are helpful in gauging its severity. In hospitalized patients with overt anemia, the TS, FEP, and MCV are much less helpful because similar changes are seen in the anemia of chronic disease. Examination of marrow iron remains the method of choice, especially in patients with infection, chronic disease, malignancy, or liver disease, although in many clinical situations the same information can be obtained from a serum ferritin. Serial measurements of serum ferritin have been particularly useful in monitoring patients at high risk of iron deficiency such as those with rheumatoid arthritis, chronic inflammatory bowel disease, or chronic renal failure.
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PMID:Clinical evaluation of iron deficiency. 676 40

We determined the platelet count and MPV in 100 normal subjects, in 147 subjects with thrombocytopenia or thrombocytosis due to other than primary hematologic disorders, and in smaller groups with immune or septic thrombocytopenia or iron deficiency. In these groups, the inverse, nonlinear relation between MPV and platelet count was the same as in a previous study of normal subjects. The same relation between platelet volume and count was found in individual patients as platelet counts rose during recovery from immune or septic thrombocytopenia. The concomitant progressive fall in MPV during recovery from thrombocytopenia, at which times rapidly rising platelets counts were necessarily associated with a population of young platelets, suggests that magnitude of stimulation of thrombopoiesis, not platelet age, is the major determinant of platelet volume. In contrast, as compared to normal persons with similar platelet counts, MPV was increased in subjects with heterozygous thalassemia but decreased in patients receiving chemotherapy for malignancy or renal transplantation. The undefined mechanism of regulation of platelet formation from megakaryocytes, reflected by the inverse relation of platelet size and count, thus seems altered in these disorders. Platelet volume is an easily obtained variable that appears to be useful in the evaluation of abnormal platelet production.
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PMID:The inverse relation between platelet volume and platelet number. Abnormalities in hematologic disease and evidence that platelet size does not correlate with platelet age. 682 64

Iron deficiency of 10 g/dl haemoglobin or less was found in 18 (3.5%) of 511 patients admitted in one year to the Middlesex Hospital Geriatric Unit. Three patients were frail and not investigated. Gastro-intestinal lesions were demonstrated in all remaining 15 patients and specific therapy was instituted in 10 cases. Surgery was performed for colonic cancer at a resectable stage (Dukes B) in two cases. Patients with iron deficiency require adequate gastro-enterological investigation.
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PMID:Gastro-intestinal bleeding--a major cause of iron deficiency in the elderly. 697 Oct 43

The accurate measurement of ferritin in the serum was first reported in 1972. Since then, the assay has become widely available to clinicians. However, the role of this assay in the diagnosis and treatment of various diseases is still poorly defined. Serum ferritin levels are clearly useful in the diagnosis of simple iron deficiency. Hepatic disease, malignancies, and other chronic diseases can cause an elevation in serum ferritin which does not represent an elevation in body iron stores. While markedly elevated in late hemochromatosis, the value of serum ferritin in the detection of early hemochromatosis or the carrier state is not certain.
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PMID:Clinical applicability and usefulness of ferritin measurements. 700 34

Five episodes of iron deficiency anemia associated with pruritus were observed in 4 women. In contrast to the majority of cases in the literature the pruritus in our patients was localized and not generalized. It disappeared 1--14 days after the beginning of iron replacement. --Iron deficiency should be considered in the differential diagnosis of both generalized and localized pruritus. The literature suggests that pruritus associated with low serum iron levels in malignancy may respond to iron therapy
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PMID:[Pruritus--a little known iron-deficiency symptom]. 728 Jun 39

The effect of iron deficiency on tumour growth and on host survival was studied in BALB/c mice with transplanted Merwin Plasma Cell-II tumors. Iron deficiency was induced by maintaining the animals on an iron-free diet consisting of milk-cornflour supplemented with CuCl2 and vitamins A and D. Iron deficiency resulted in retardation of both body and tumor growth in weanling BALB/c mice. Their survival, however, was not significantly different from that of iron supplemented controls. The inhibitory effect of iron deficiency on host and tumour growth could not be reproduced in adult BALB/c mice. The survival of tumor-bearing hosts maintained on a milk-cornflour diet (whether supplemented with iron or not) was significantly longer than that of animals maintained on a purina diet.
Nutr Cancer 1981
PMID:Effect of iron deficiency on transplantable murine plasmacytoma. 734 86

Noninvasive evaluation for iron deficiency is compromised in many individuals due to the presence of chronic inflammatory processes and/or malignancy, thus necessitating bone marrow examination for definitive diagnosis. However, bone marrow aspiration is not obtainable or is inadequate for interpretation (dry tap) in some individuals, and decalcified bone marrow biopsies require 24-48 hr to prepare, and may falsely indicate absence of iron. We evaluated the accuracy of bone marrow biopsy imprints (touch preparations) compared with aspirate particle smears for semiquantitation of bone marrow iron stores. Results indicate that Prussian blue-stained bone marrow biopsy imprints accurately reflect the quantity of iron, compared with bone marrow aspirate particle smears, allowing for rapid determination of iron stores in individuals in whom a bone marrow aspirate cannot be obtained.
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PMID:Bone marrow biopsy imprints (touch preparations) for assessment of iron stores. 753 54


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