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Query: UMLS:C0240066 (iron deficiency)
 7,156 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. A state of protein deficiency has been produced in rats by feeding a low protein diet, thereafter a period of rehabilitation with a normal protein but a low iron supply followed. 2. For characterization of the iron metabolism during both periods haemoglobin, total iron binding capacity, liver non-haemin iron, intestinal iron absorption and the uptake of 59Fe in the liver was determined. 3. Under these conditions the amount of 59Fe incorporated into the mucosal transferrin and the ferritin fractions has been measured. Both fractions were obtained from the supernatant of a mucosal homogenate after chromatography on sepharose 6B. 4. In anemia due to protein deficiency the typical increase of 59Fe incorporation into the fraction of mucosal transferrin--usually occuring in iron deficiency--could not be observed. This coincides with the absence of an increased iron absorption. Moreover a decrease of iron absorption is observed, which is associated with a decreased 59Fe ratio of transferrin/ferritin-fraction. 5. After normalization of the protein supply the ratio of 59Fe incorporated into the mucosal transferrin and ferritin fractions was changed remarkably in favor to transferrin together with a several fold increase of the intestinal iron absorption. 6. The conclusion is drawn that mucosal transferrin and ferritin enable the body not only to adapt the absorption to a higher but also to a lower requirement as it is the case in protein deficiency.
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PMID:The role of mucosal iron binding proteins in adaptation of iron absorption during protein deficiency and rehabilitation. 68 93

Newborn mice with X-linked anaemia (gene symbol sla) have lower haemoglobin levels at birth than normal and carrier mice but there is considerable overlap. Serial observations showed that the haemoglobin values of segregating male mice separate into a bimodal distribution of 42 d of age, and 50 d values were used to assign genotypes retrospectively. The anaemia in newborn sla mice is attributable to iron deficiency, since their total body iron is lower than in normal newborn mice, while their birth weights are almost identical. Haemoglobin levels at birth in normal, anaemic and carrier mice are also influenced by the mother's genotype and phenotype, and the haemoglobin value was progressively lower according to the sla gene dose of the mother. Materno-fetal iron transfer was examined by labelling pregnant carrier females with radioiron in various ways. When given as single or intermittent doses by injection no clearcut differences emerged in apparent iron transfer to anaemic as compared to non-anaemic fetuses. However, when radioiron was administered continuously in food a significant reduction in iron transfer to anaemic fetuses was demonstrated. The sla gene is already known to have a major effect in reducing iron transport in the small intestine. The present studies provide evidence of an analogous defect in placental iron transport.
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PMID:Iron deficiency anaemia in newborn sla mice: a genetic defect of placental iron transport. 70 46

The percentage of fat-cell areas in bone marrow particles from 22 patients with untreated myelomatosis was estimated. In only 1 patient was the mean fat cell area below 25% of the bone marrow area measured. A negative correlation was found between the area of fat cells and plasma cells, indicating a displacement of the fat cell area by the plasma cells. 28% of the patients had empty bone marrow deposits of iron. However, based on a normal iron saturation of S-transferrin and a normal sideroblast count in the bone marrow, the supply of iron to the erythropoiesis was considered sufficient. All patients but one had normoblastic bone marrows. Using a deoxyuridine suppression test in 10 patients, no biochemical defect could be demonstrated. To judge from the correlation coefficient a minor degree (9-14%) of the variation in Hb values could be predicted from the cellularity in the bone marrow while a major degree (70%) could be predicted from the renal glomerular filtration rate. The results do not support a displacement of blood-forming elements, iron deficiency, vitamin B12 or folic acid deficiency to be of general significance in the pathogenesis of anaemia, but agrees with a causal relationship between anaemia and renal failure.
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PMID:Bone marrow studies in myelomatosis. 71 78

We followed up 238 infants on 7 occasions during their first year of life. The diets of the infants were systematically either supplemented or not supplemented with iron. Developmental changes in serum ferritin were determined from a group with adequate intake of iron and without evidence of iron deficiency by three laboratory criteria: hemoglobin, mean corpuscular volume and transferrin saturation. The data indicate that the average level of serum ferritin correlates well with iron nutrition within groups of infants since the developmental changes are in accordance with the known changes in storage iron, the level of serum ferritin correlates with iron intake, and low ferritin levels are associated with lower transferrin saturation. The usefulness of serum ferritin as the sole criterion of iron deficiency in individual infants is limited, suggesting the use of more than one indicator to refine the diagnosis of iron deficiency without anemia.
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PMID:Serum ferritin in assessment of iron nutrition in healthy infants. 71 74

In a previous study of secondary lead smelter workers (males), a significant prevalence of low hemoglobin levels (less than 14 g/100 ml) was found; a statistically significant negative correlation between hemoglobin and zinc protoporphyrin was also detected. In the present study serum iron (Fe) levels and total iron binding capacity (TIBC) were included in the investigation of 111 secondary lead smelter workers and 37 nonexposed controls. The distribution and mean values of serum iron and TIBC were found to be in the normal range in the lead exposed workers; there was no significant difference when compared to the control population. There was no significant correlation between blood lead or zinc protoporphyrin and serum iron, TIBC and Fe/TIBC. A statistically significant negative correlation between hemoglobin and blood lead levels was found; the correlation between hemoglobin and zinc protoporphyrin reached a much higher level of significance. The results support the view that anemia (low hemoglobin levels) in lead exposed male workers is related to the heme synthesis inhibiting effects of lead, as reflected by elevated zinc protoporphyrin levels, and is not due to iron deficiency.
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PMID:Hemoglobin, serum iron, and zinc protoporphyrin in lead-exposed workers. 72 Mar 9

As part of a study of anemia associated with oral contraceptive use, serum vitamin B12 levels, unsaturated B12-binding capacity, and B12 binder fractionation were examined in 67 consecutive mildly anemic (hemoglobin levels below 13 gm%) women using oral contraceptives and 59 such women using other means of birth control. Results were correlated with hematologic parameters such as complete blood counts and evaluation of iron status. Hemoglobin levels were significantly lower (p 0.01) in the non-oral-contraceptive group, while serum iron levels were significantly higher (p 0.05) in the oral contraceptive group and fewer oral contraceptive users demonstrated iron-deficiency anemia. While no B12-deficient subjects were found, serum B12 levels were significantly lower among oral contraceptive users (p 0.05), but differences were more striking between iron-deficient and non-iron deficient subjects, regardless of oral contraceptive status (p 0.02). The role of iron status needs further clarification as the finding of higher serum B12 levels in iron-deficient subjects contrasts with previous reports of lower B12 levels in cases of disease-related iron deficiency. Moreover, the relationship between iron status and serum B12 level was significant only in the oral contraceptive group. Among pill users, iron deficiency was most frequent in those taking sequential rather than combination preparations (67 vs. 39%). Among non-oral-contraceptive subjects, iron deficiency incidence was 96% in IUD users. Serum unsaturated B12 binding capacity was unaffected by pill use, but pill users showed significantly higher transcobalamin I levels, correlating best with white blood cell counts. The assumption that this elevation reflects pill effect on protein synthesis is premature, even though a general increase in alpha 1-globulin has been reported in pill users. Transcobalamin II and 3rd binder levels were not affected and did not correlate with white blood counts. The correlation between UBBC levels and white blood cell counts was significant in both oral contraceptive and non-oral-contraceptive groups. In contrast to previous findings, UBBC could not correlated with any iron parameter.
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PMID:Serum vitamin B12 and B12-binding protein levels associated with oral contraceptives. 72 97

Anaemia is common in renal insufficiency and has various causes: 1) depressed marrow production of red cells, probably due to reduced production of erythropoietin, though the possibility of direct marrow inhibition on the part of uraemic toxins cannot be ruled out, together with iron deficiency, as occurs in prolonged dialysis management; 2) greater red cell destruction attributable to extraglobular factors and other mechanisms (microangiopathy, drugs, etc.); 3) greater blood loss following thrombocytopenia, reduced platelet adhesivity and agglutinability, dialysis. The main premisses on which the treatment of anaemia of uraemic patients is based are discussed.
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PMID:[Anemia in chronic renal insufficiency]. 73 54

A survey on the prevalence of iron deficiency anaemic was performed in 1160 pediatric out-patients of the General Hospital in Surabaya. Criteria for anaemia were haemoglobin concentrations of less than 10, 11 and 12g% for the age groups of 6 months to 2 years (I), 2 to 5 years (II) and 5 to 12 years (III), respectively. Criteria for Fe-deficiency among the anaemic children were serum transferrin saturation of less than 16% and a bone marrow devoid of iron. In group I 12,8% of the children had Fe-deficiency anaemia, in group II 10,7% and in group III 7,6%. The over-all prevalence of anaemia was 14,2% and of iron deficiency anaemia 9,8%.
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PMID:Prevalence of iron deficiency anaemia among Indonesian children. 73 60

Whole blood delta-aminolaevulinic acid (ALA) concentrations and erythrocyte ALA dehydratase activity have been measured in patients with iron deficiency anaemia, megaloblastic anaemia and secondary anaemia, and in normal subjects. ALA concentration was found to be significantly increased in all types of anaemia compared with normal. Erythrocyte ALA dehydratase activity was significantly increased in iron deficiency and megaloblastic anaemia but not in secondary anaemia.
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PMID:Erythrocyte delta-aminolaevulinic acid dehydratase activity and changes in delta-aminolaevulinic acid concentration in various forms of anaemia. 74 26

The diagnostic value of serum ferritin measurements in discriminating iron-deficiency anemia from thalassemia trait has been studied. In contrast to serum iron, percent transferrin saturation and total iron-binding capacity, where a high degree of overlap existed between the two groups, a clear-cut difference in serum ferritin levels was found between iron deficiency and thalassemia trait. The best separation of iron deficiency, thalassemia and normal controls was given by the combination of mean corpuscular volume and serum ferritin. Although definitive diagnosis of beta-thalassemia trait requires the demonstration of abnormal Hb A2 levels or beta-chain synthesis, serum ferritin is a useful screening test for the initial diagnosis of thalassemia trait. Because of the very small amounts of serum required for the measurement of ferritin, it is particularly suitable for surveying populations with a high prevalence of hypochromic-microcytic anemias.
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PMID:Serum ferritin in beta-thalassemia trait. 75 May 37


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