Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0239946 (liver fibrosis)
 8,268 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
collagen 1627
Mol 597
SMA 591
Sep 490
smooth muscle actin 480
aspartate aminotransferase 445
alanine aminotransferase 416
cytokine 356
interferon 329
insulin 279
TNF 227
AST 207
albumin 200
tumor necrosis factor 193
alpha-smooth muscle actin 192
matrix metalloproteinase 160
type I collagen 159
FIB 158
Smad3 150
IL-6 149
HSC 149
platelet-derived growth factor 145
fibronectin 144
alkaline phosphatase 141
Smad2 135
caspase-3 131
IFN 129
EPA 125
superoxide dismutase 103
GSH 102
PDGF 100
CD4 94
TGF-beta 92
serum albumin 91
connective tissue growth factor 89
IL-10 86
gut 84
TLR4 83
MMP-2 81
chemokine 77
Bcl-2 75
p38 75
transforming growth factor-beta 74
MRI 74
vascular endothelial growth factor 73
leptin 72
ERK 72
AKT 71
desmin 70
lipopolysaccharide 69
endoplasmic reticulum 68
PI3K 68
catenin 65
metalloproteinase 65
ferritin 63
vimentin 63
MMP-9 62
inducible nitric oxide synthase 61
hepatocyte growth factor 61
peroxisome proliferator-activated receptor 60
interleukin-6 59
MAPK 59
ERK1 58
renin 58
collagenase 57
JNK 55
IL-13 55
adiponectin 54
ECM 50
LPS 50
tissue inhibitor of metalloproteinases 50
catalase 49
STAT3 49
p53 49
glutathione peroxidase 48
Smad7 47
PPAR 46
prothrombin 46
HCC 46
surface antigen 45
alpha-fetoprotein 44
p65 44
TNF-alpha 43
ROS 43
TIMP-2 43
CD8 42
M2BP 42
angiotensin II 41
COL1A1 41
SOD 41
IL-4 41
transforming growth factor beta 1 40
histone 40
PEG 39
glycoprotein 39
E-cadherin 39
peroxisome proliferator-activated receptor gamma 38
mTOR 38
MMP-13 37
TIMP1 37
ATP 36
Nrf2 36
hemochromatosis 35
ALP 35
osteopontin 35
plasminogen activator inhibitor-1 35
erythroid 35
IL-17 35
cyclooxygenase-2 34
MMP9 34
MMP-1 34
Cytokine 34
tumor necrosis factor alpha 34
MCP-1 34
Ang II 33
proliferating cell nuclear antigen 33
tyrosine kinase 33
CCL2 33
p21 33
lactate dehydrogenase 33
VEGF 32
gamma-glutamyl transpeptidase 32
hemoglobin 31
CTGF 31
Leptin 31
AMPK 31
signal transducer and activator of transcription 3 30
UTR 30
transforming growth factor-beta 1 30
NLRP3 29
cytochrome P450 28
cyclin D1 28
extracellular signal-regulated kinase 28
PNPLA3 27
MMP2 27
GGT 27
c-Jun 27
endothelin-1 26
IL28B 26
smooth muscle alpha-actin 26
tissue inhibitor of metalloproteinase 1 25
transferrin 25
CCL4 25
IFN-gamma 25
kit 25
cytokeratin 19 25
CD34 25
IL-8 25
core protein 25
SMAD3 24
Sp1 24
LC3 24
ras 24
heme oxygenase-1 24
lymphoid 24
Pol 24
myeloperoxidase 23
IL-1 23
CD68 23
hedgehog 23
more...
Disease
liver fibrosis 8268
cirrhosis 2386
liver disease 1138
hepatocellular carcinoma 1026
chronic hepatitis 891
hepatitis C 743
chronic liver disease 565
fatty liver 512
cancer 375
hepatitis B 353
portal hypertension 316
hepatitis 294
obesity 268
viral hepatitis 259
tumor 244
diabetes 238
Nonalcoholic fatty liver 232
liver cancer 228
cholestasis 211
schistosomiasis 209
alcoholic fatty liver 201
HIV 181
liver cancer 181
metabolic syndrome 163
virus infection 150
type 2 diabetes 116
GSH 102
immunodeficiency 101
carcinogenesis 99
Schistosoma mansoni 96
iron overload 90
Schistosoma japonicum 87
Cirrhosis 81
hypertension 78
primary biliary cirrhosis 70
biliary atresia 70
alcohol abuse 68
Chronic hepatitis C 68
tumorigenesis 65
Hepatocellular carcinoma 62
cholangitis 61
atherosclerosis 58
esophageal varices 57
cardiovascular disease 52
HCC 46
primary sclerosing cholangitis 46
AIDS 45
acute hepatitis 45
pulmonary fibrosis 44
hemochromatosis 43
viremia 42
alcoholic hepatitis 41
renal disease 41
chronic active hepatitis 41
dyslipidemia 38
alcoholic cirrhosis 36
ischemia 36
heart failure 34
HCV coinfection 34
infectious diseases 34
rheumatoid arthritis 33
psoriasis 33
carcinoma 33
anemia 33
varices 33
tumor growth 33
hyperglycemia 32
alcoholism 31
Chronic hepatitis B 30
hyperlipidemia 28
malnutrition 26
chronic disease 25
thalassemia 25
Schistosoma mansoni infection 25
hepatic encephalopathy 25
biliary obstruction 24
thrombocytopenia 23
renal failure 23
sepsis 22
Blocking 22
NS3 22
gallstones 21
Best 21
pruritus 21
polycystic kidney 21
idiopathic pulmonary fibrosis 20
NPHP1 19
Infection 19
sepsis 19
tumor progression 19
hepatitis E 19
worms 19
thalassemia major 17
heart disease 17
Alcoholic liver disease 17
CCL 16
inflammatory bowel disease 16
HGF 16
Down syndrome 16
Chronic infection 16
parasitic disease 15
osteoporosis 15
renal cyst 15
NOD 14
stroke 14
hyperinsulinemia 14
vasculitis 14
encephalopathy 14
West 14
pulmonary hypertension 14
B-cell lymphoma 14
proteinuria 13
depression 13
glucose intolerance 13
ulcerative colitis 13
breast cancer 13
metastases 13
asthma 13
hypercholesterolemia 12
hyperbilirubinemia 12
hepatitis D 12
Wilson's disease 12
haemophilia 12
chronic persistent hepatitis 12
hypoglycemia 12
pancreatitis 12
cytomegalovirus 11
cystic fibrosis 11
chronic renal failure 11
cryoglobulinemia 11
FAS 11
EMT 11
cardiomyopathy 11
hereditary hemochromatosis 11
autoimmune disease 11
Alzheimer's disease 11
Joubert syndrome 11
Echinococcus 10
dysplasia 10
Hodgkin's disease 10
glomerulonephritis 10
PSS 10
osteoarthritis 10
leukemia 10
metabolic disorder 10
glycogen storage disease 10
sickle cell disease 10
hepatitis A 10
myocardial infarction 10
liver scarring 10
Budd-Chiari syndrome 10
Haemophilia 10
Hepatotoxicity 10
vitamin D deficiency 10
ATM 10
hypersplenism 10
malaria 9
psoriatic arthritis 9
acute myeloid leukemia 9
Adenovirus 9
more...
Symptom
hepatomegaly 62
splenomegaly 53
overweight 29
pain 29
ataxia 15
hepatosplenomegaly 14
fatigue 14
diarrhea 14
HSA 11
exhaustion 11
abdominal pain 10
weakness 10
Stiffness 9
anesthesia 9
hypotonia 8
seizures 7
starvation 6
discomfort 5
arthralgia 5
discomfort 5
cough 5
cerebellar ataxia 4
regurgitation 4
anorexia 3
respiratory distress 3
collapse 3
erythema 3
vomiting 3
angina 3
polydipsia 2
leg edema 2
nausea 2
loss of balance 2
tremor 2
dyspnea 2
dystonia 2
cachexia 2
pallor 2
dark urine 2
polyuria 2
tenesmus 1
stigma 1
flushing 1
functional recovery 1
frequent urination 1
myalgia 1
chest pain 1
hypoproteinemia 1
abdominal discomfort 1
hunger 1
neuralgia 1
agitation 1
night sweats 1
apathy 1
hyperoxia 1
general problem 1
sleepiness 1
lethargy 1
dysarthria 1
hypercapnia 1
skin damage 1
emaciation 1
Balding 1
enuresis 1
headache 1
right upper quadrant pain 1
skin irritation 1
Spots 1
Anoxia 1
Ill 1
Drug
ROS 43
ROC 36
Portal 35
vitamin E 30
IFN-gamma 25
Monit 21
lysine 21
Ethanol 19
Angiotensin II 19
Dermatol 17
ascorbate 16
CCL 16
IL-2 15
Biopolymers 14
Sorafenib 14
caffeine 14
Vitamin A 12
Vitamin E 8
Albumin 8
Activin 8
Emodin 7
Kenyan 7
Emodin 7
Serum albumin 6
Glutathione 6
Retinoic acid 6
Cardiovasc 6
MAP 5
Gel 5
Pirfenidone 5
p75 5
Fructose 5
Ginseng 4
ABC 4
uPA 4
Tenofovir 4
Gelatin 4
Amiloride 4
CSF 4
EPI 4
Dial 4
PMPA 4
ETA 4
Infliximab 3
Rituximab 3
PFT 3
Imatinib 3
ETS 3
IFN-beta 3
Simvastatin 3
Spectrum 3
citric acid 3
Infliximab 3
Ezetimibe 3
Secretin 3
Glucagon 3
Leaf 3
Glycyrrhiza 3
ATV 3
Parkin 3
Parkin 3
Liraglutide 3
NOV 3
Nephron 2
Zileuton 2
Rimonabant 2
TAK 2
PTC 2
Nitric Oxide 2
Verteporfin 2
Histamine 2
Myricetin 2
TAT 2
Artesunate 2
Cilostazol 2
ADM 2
Nephron 2
Oxaliplatin 2
BH4 2
Swertia 2
Epigallocatechin 2
GEO 2
Vitamin B 2
NAG 2
EPA 2
RFP 2
Gleevec 2
Calcipotriol 2
Heme 2
Paraffin 2
Tolvaptan 2
Trapidil 2
Aloe 2
Malotilate 2
TiO2 2
ddI 1
BLM 1
Sandostatin 1
Omacor 1
Triclosan 1
Bezafibrate 1
Bifidobacterium 1
Ranitidine 1
Orlistat 1
Everolimus 1
Fluorescein 1
Acacia 1
nitroglycerin 1
DNase I 1
Valganciclovir 1
Camellia oil 1
Fenbendazole 1
Viagra 1
Beta-2 1
MRC 1
IL-11 1
Digenea 1
SMP 1
Imiquimod 1
Pronase 1
Olmesartan 1
PMEA 1
Aliskiren 1
HCG 1
Olive oil 1
Mesalazine 1
AMC 1
Spectrum 1
CTC 1
Rutin 1
Vinpocetine 1
all-trans-retinol 1
DPA 1
Ulinastatin 1
Limonene 1
AC2 1
Clodronate 1
LMWH 1
Alliance 1
niacin 1
PDL 1
Ketorolac 1
ampicillin 1
Ramipril 1
Etravirine 1
Gefitinib 1
IPM 1
Ketotifen 1
Tocopherol 1
LCM 1
Crystal Violet 1
MDM 1
Indomethacin 1
Arsenic trioxide 1
Midostaurin 1
lactose 1
LCM 1
Indocyanine green 1
Perindopril 1
Sandostatin 1
more...
Enzyme
alanine aminotransferase 736
aspartate aminotransferase 635
mitogen-activated protein kinase 227
AST 207
collagenase 145
alkaline phosphatase 141
superoxide dismutase 137
ERK 135
caspase-3 100
gamma-glutamyl transpeptidase 97
luciferase 80
protein kinase 64
catalase 63
renin 58
type III procollagen 54
glutathione peroxidase 49
focal adhesion kinase 47
AMP-activated protein kinase 42
lactate dehydrogenase 34
NADPH oxidase 34
NADPH oxidase 33
peroxidase 31
AMPK 31
AMPK 31
glutathione S-transferase 31
prolyl hydroxylase 30
reverse transcriptase 26
ACE 25
PARP 24
interstitial collagenase 23
MMP 22
urokinase-type plasminogen activator 22
phosphatidylinositol 3-kinase 21
caspase-1 18
protein kinase C 18
lysyl oxidase 18
thrombin 15
matrix metalloproteinase 2 14
MEK 14
MMP-3 13
caspase-8 13
trypsin 12
proteasome 12
matrix metalloproteinase 9 12
alcohol dehydrogenase 12
caspase-9 11
cholinesterase 11
transglutaminase 10
IKK 10
NQO1 10
heme oxygenase 10
RNase 10
APC 10
acetylcholinesterase 10
aldehyde dehydrogenase 10
ceruloplasmin 9
RNase 9
NOS 9
lipase 9
ACS 8
plasmin 8
phosphodiesterase 8
aldehyde dehydrogenase 7
aldehyde dehydrogenase 7
cdc2 7
GSK 7
glutamine synthetase 7
aldehyde dehydrogenase 7
aldehyde dehydrogenase 7
RNA polymerase 7
transcriptase 7
xanthine oxidase 7
chymase 6
guanylate cyclase 6
tissue plasminogen activator 6
calcineurin 6
phosphoinositide 3-kinase 6
ATPase 6
demethylase 6
NO synthase 6
hyaluronidase 5
CD10 5
elastase 5
CYP7A1 5
fumarylacetoacetate hydrolase 5
phosphorylase kinase 5
DNA methyltransferase 5
methionine adenosyltransferase 5
CYP3A4 5
chitinase 5
phospholipase A2 5
arginase 5
creatine kinase 5
monoamine oxidase 5
soluble epoxide hydrolase 5
lysophospholipase D 4
transpeptidase 4
pepsin 4
hyaluronidase 4
glutamate dehydrogenase 4
cathepsin B 4
glutamate dehydrogenase 4
ribonuclease 4
angiotensin-converting enzyme 2 4
ribonuclease 4
tryptase 4
thromboplastin 4
gamma-glutamylcysteine synthetase 4
MAP 4
MIP 4
thymidine kinase 4
glutamate dehydrogenase 4
ornithine decarboxylase 3
arylalkylamine N-acetyltransferase 3
estrogen sulfotransferase 3
neutrophil elastase 3
PKG 3
indoleamine 2,3-dioxygenase 3
tryptophan 2,3-dioxygenase 3
adenylate cyclase 3
UDP-glucuronosyltransferase 3
MEKK1 3
5'-nucleotidase 3
methylenetetrahydrofolate reductase 3
ALDH 3
caspase-7 3
DNA polymerase 3
methylenetetrahydrofolate reductase 3
prolidase 3
furin 3
caspase-7 3
12-lipoxygenase 3
galactosylhydroxylysyl glucosyltransferase 3
phosphomannose isomerase 3
lipoprotein lipase 3
endothelin-converting enzyme 3
sphingosine kinase 3
AOR 3
succinate dehydrogenase 3
nucleotidase 2
phospholipase D 2
TAT 2
kallikrein 2
glutathione reductase 2
glyceraldehyde-3-phosphate dehydrogenase 2
adenosine deaminase 2
SST 2
cathepsin D 2
CYP27A1 2
glyceraldehyde-3-phosphate dehydrogenase 2
Thy1 2
adenosine deaminase 2
CPR 2
P-glycoprotein 2
beta-glucuronidase 2
histone acetyltransferase 2
lipoxygenase 2
phenylalanine hydroxylase 2
firefly luciferase 2
inosine triphosphatase 2
more...
Compound
Dec 499
Clin 492
CCl4 477
DNA 379
oxygen 232
TNF 227
ethanol 195
hyaluronic acid 180
iron 177
glucose 169
water 165
Collagen 122
GSH 106
GSH 106
methionine 101
nitric oxide 62
phosphate 62
retinol 58
calcium 53
sodium 52
ASA 52
PEG 51
aldehyde 48
TAA 44
alanine 43
proline 42
MTT 42
PEG 42
acetaldehyde 41
galactose 38
retinoic acid 37
zinc 37
ATP 36
ALP 35
MDA 34
urea 34
cysteine 33
hydrogen 33
vitamin D 33
Insulin 32
Curcumin 32
Angiotensin II 32
acetate 32
tyrosine 30
arginine 30
copper 27
lysine 26
creatinine 25
aldehyde 25
DMN 25
salt 24
N-acetylcysteine 22
Ang II 21
cAMP 20
Hydroxyproline 20
Silymarin 19
Hematoxylin 19
nitrogen 18
His 16
GPT 16
leucine 16
Resveratrol 16
CAT 16
CAT 16
dUTP 16
Ribavirin 16
CAT 16
Vitamin D 16
tryptophan 15
DEN 15
sulfate 15
NADPH 14
caffeine 14
Melatonin 14
Methotrexate 14
Cardiol 14
bromide 14
NADPH 14
nicotinamide 14
NKT 13
tryptophan 13
adenosylmethionine 13
methanol 13
tryptophan 13
Asp 13
palmitic acid 13
tryptophan 13
Vitamin A 12
AMP 12
palmitic acid 12
Oil Red O 12
Phe 12
Praziquantel 12
TOF 11
H2O2 11
iodine 11
glutamate 11
alcohol dehydrogenase 11
glutamine 11
NH2 11
Azan 10
aldosterone 10
Ile 10
PGE2 10
Oil Red O 10
ammonia 10
GSSG 10
serine 10
SDS 10
APAP 10
glucose-6-phosphate 10
Colchicine 10
GTP 10
4-hydroxyproline 9
diacetate 9
ACS 9
Quercetin 9
Taurine 9
4-hydroxyproline 9
vinyl 9
isoleucine 9
4-hydroxyproline 9
4-hydroxyproline 9
4-hydroxyproline 9
homocysteine 9
4-hydroxyproline 9
NAD 8
MEK 8
GlcNAc 8
ACS 8
betaine 8
Emodin 8
gallic acid 8
Vitamin E 8
Pac 8
Gly 8
Optimal 8
glycerol 8
isoleucine 8
Ursodeoxycholic acid 8
H2S 8
Adenosine 8
8-OHdG 8
valine 8
nitrate 7
Pentoxifylline 7
Matrine 7
threonine 7
Matrine 7
TEM 7
DTPA 7
CoA 7
Emodin 7
NAD 7
CO2 7
Vimentin 7
aspartic acid 7
Matrine 7
selenium 7
THP 6
more...