Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0239946 (liver fibrosis)
 8,268 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The molecular pathogenesis of schistosomal liver fibrosis has been studied in a murine model of Schistosoma mansoni. A novel fibroblast growth factor, fibrosin, was identified as a product of a subpopulation of CD4+ lymphocytes resident in the hepatic egg granulomas. We describe a sensitive, quantitative, antigen-capture enzyme-linked immunosorbent assay that can detect fibrosin in mouse serum and plasma at concentrations > 0.05 pg/ml. Using this assay, we detected in infected mice circulating fibrosin levels that were several-fold increased above those detected in uninfected controls. Circulating fibrosin levels increased after week 4 of infection, reached a peak at week 8, and normalized by week 12. We propose that circulating fibrosin might be a useful marker of hepatic fibrogenesis in schistosomiasis.
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PMID:A quantitative assay to detect circulating fibrosin and its application in experimental schistosomiasis. 906 64