Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0239946 (
liver fibrosis
)
8,268
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The molecular mechanism of
liver fibrosis
caused by hepatitis C virus (HCV) is not clear. The aim of this study is to understand the molecular mechanism of
liver fibrosis
induced by HCV and to identify potential therapeutic targets for hepatic fibrosis. We analyzed gene expression patterns between high
liver fibrosis
and low
liver fibrosis
samples, and identified genes related to
liver fibrosis
. We identified
TAF1
, HNF4A, and CALM2 were related to the development of
liver fibrosis
. HNF4A is important for hepatic fibrogenesis, and upregulation of HNF4A is an ideal choice for treating
liver fibrosis
. The gene expression of CALM2 is significantly lower in
liver fibrosis
samples than nonfibrotic samples.
TAF1
may serve as a biomarker for
liver fibrosis
. The results were further validated by an independent data set GSE84044. In summary, our study described changes in the gene expression during the occurrence and development of
liver fibrosis
. The
TAF1
, HNF4A, and CALM2 may serve as novel targets for the treatment of
liver fibrosis
.
...
PMID:Identification of TAF1, HNF4A, and CALM2 as potential therapeutic target genes for liver fibrosis. 3031 8
