Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Drug
Enzyme
Compound
Query: UMLS:C0239946 (
liver fibrosis
)
8,268
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Sodium selenite has alleviating effects on
liver fibrosis
; however, its therapeutic molecular mechanism remains unclear. Herein, hydrogen selenide, a major metabolite of Na
2
SeO
3
, was tested to uncouple the sulfilimine bond in collagen IV, the biomarker of
liver fibrosis
. A mouse model of
liver fibrosis
was constructed via a CCl
4
-induced method, followed by the administration of 0.2 mg kg
-1
Na
2
SeO
3
via gavage three times per week for 4 weeks. Changes in H
2
Se, NADPH, and H
2
O
2
levels were monitored in real time by using NIR-H
2
Se,
DCI
-MQ-NADPH, and H
2
O
2
probes in vivo, respectively. H
2
Se continuously accumulated in the liver throughout the Na
2
SeO
3
treatment period, but the levels of NADPH and H
2
O
2
decreased. The expression of collagen IV was analyzed through Western blot and liquid chromatography-mass spectrometry. Results confirmed that the sulfilimine bond of collagen IV in the fibrotic mouse livers could be broken by H
2
Se with the Na
2
SeO
3
treatment. Therefore, the therapeutic effect of Na
2
SeO
3
on
liver fibrosis
could be mainly attributed to H
2
Se that uncoupled the sulfilimine bond to induce collagen IV degradation. This study provided a reasonable explanation for the molecular mechanism of the in vivo function of Na
2
SeO
3
and the prevention of
liver fibrosis
by administering inorganic selenium.
...
PMID:Hydrogen selenide, a vital metabolite of sodium selenite, uncouples the sulfilimine bond and promotes the reversal of liver fibrosis. 3288 Aug 66
