Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0239946 (
liver fibrosis
)
8,268
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Treatment of
liver fibrosis
associated with Schistosoma japonicum ova-induced granulomas remains a challenging proposition. Paeoniflorin (
PAE
, C23H28O11) has anti-inflammatory, anti-allergic, and immunoregulatory effects and it is commonly used in Chinese Herbal prescriptions to treat hepatic disorders. The present study was carried out to investigate the effects of
PAE
on hepatic fibrosis of mice infected with S. japonicum and to explore its possible mechanism. Upon pathological examination of
PAE
-treated mice, the size of egg granuloma, fibrosis scores, the concentration of IL-13 and hydroxyproline in liver were significantly reduced compared with the model mice. In the primary culture of hepatic stellate cells (HSCs),
PAE
inhibited IL-13-induced collagen synthesis. These results suggested that
PAE
might alleviate the hepatic granulomas and fibrosis caused by S. japonicum and the inhibitory effect of
PAE
on hepatic fibrosis might be associated with its ability to decrease the level of IL-13 and to interfere with the IL-13 signalling molecule in HSCs.
...
PMID:Paeoniflorin ameliorates schistosomiasis liver fibrosis through regulating IL-13 and its signalling molecules in mice. 2039 36
