Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0238111 (Lennox-Gastaut syndrome)
 861 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
Chromodomain-helicase-DNA-binding protein 2 15.2
IRF2BPL 13.6
CLCN4 11.7
KPNA7 11.6
XLIS 11.6
ALG13 11.6
LGS 11.4
KCNT2 11.3
CHD2 11.2
STXBP1 11.1
KCNT1 10.9
DNM1 10.9
IQSEC2 10.9
ST3GAL3 10.8
SMEI 10.8
ARFGEF2 10.7
SLACK 10.7
brefeldin A-inhibited 10.6
GABRA1 10.5
GABRB2 10.4
GABRB3 10.4
PURA 10.2
GABRD 10.1
syntaxin-binding protein 1 10.1
GABRA6 10.1
SLC9A6 9.7
EMX2 9.7
RYR3 9.7
MACF1 9.6
NDUFV2 9.5
SCN8A 9.3
GABRG2 9.3
PCDH19 9.1
COL18A1 9.0
CLB 8.9
EEF1A2 8.9
NEDD4L 8.9
nuclear transport receptor 8.8
dynamin 1 8.8
SCN1A 8.7
GRIN1 8.6
GPR55 8.6
SAF-A 8.5
KPNA2 8.4
AED 8.3
GB2 8.2
CDKL5 8.1
SV2A 8.0
GPR56 8.0
FLNA 7.9
dihydropteridine reductase 7.9
fukutin 7.9
Cav3.1 7.9
DHPR 7.8
RELN 7.8
Nav1.1 7.7
LIS1 7.7
Thyrotropin-releasing hormone 7.6
Fukuyama-type congenital muscular dystrophy 7.5
MERRF 7.5
CBD 7.4
SHANK3 7.4
GRIN2B 7.3
SME 7.3
dentatorubral-pallidoluysian atrophy 7.3
ARX 7.3
TNC 7.2
GBP 7.2
filamin A 7.2
GABA transaminase 7.1
BF2 7.1
orphan G protein-coupled receptor 7.1
Pur 7.0
Rett syndrome 6.9
oncogene) 6.9
BCL11A 6.9
ENT1 6.7
CACNA1A 6.6
LCT 6.5
FACE 6.4
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Disease
epilepsy; symptomatic 15.2
Lennox-Gastaut syndrome 15.2
Lennox-Gastaut syndrome 15.1
Nodding spasm 14.2
Atypical absence seizures 14.0
Benign neonatal seizures 13.9
Gurrieri syndrome 13.6
Atypical benign partial epilepsy 13.4
Epilepsy with myoclonic absences 13.4
Myoclonic Encephalopathy 13.4
Childhood epilepsy with occipital paroxysms 13.2
Benign focal epilepsy of childhood 13.2
atonic seizure 13.1
Other epilepsy 12.9
epileptic twilight state 12.7
hypsarhythmia 12.7
Myoclonic astatic epilepsy 12.6
Ohtahara syndrome 12.6
Benign myoclonic epilepsy in infancy 12.4
ABPE 12.2
Intractable epilepsy 11.9
XLIS 11.9
Lennox syndrome 11.8
Landau-Kleffner syndrome 11.6
Photosensitive epilepsy 10.9
ring chromosome 20 10.9
immature personality 10.9
Epileptic encephalopathy 10.8
Opsoclonus myoclonus 10.7
Hepatic impairment 10.5
LGS 10.4
A-V malformation 10.4
juvenile myoclonic epilepsy 10.4
trisomy 15q 10.4
IGE 9.9
frontal lobe syndrome 9.7
petit mal 9.6
Rasmussen encephalitis 9.4
Epilepsia partialis continua 9.4
Generalized epilepsy 9.3
reflex epilepsy 9.3
psychomotor epilepsy 9.2
EME 9.1
Cerebellar atrophy 9.1
pachygyria 9.0
mumps meningitis 9.0
complex partial seizures 8.9
keratomalacia 8.8
focal epilepsy 8.8
AIC 8.7
GEFS+ 8.7
myoclonus epilepsy 8.7
hyperprolinemia 8.6
schizencephaly 8.6
Nonconvulsive status epilepticus 8.6
generalized seizure 8.5
epilepsy 8.4
grand mal epilepsy 8.3
SME 8.1
status epilepticus 8.1
PME 8.1
encephalopathy 8.0
Fukuyama congenital muscular dystrophy 8.0
intellectual impairment 8.0
Neonatal seizures 7.9
tuberous sclerosis 7.9
lissencephaly 7.9
Frontal lobe 7.8
Behavioral problems 7.7
febrile convulsions 7.7
Alpers 7.7
OSX 7.7
Cannabis 7.7
Syndrome 7.6
MERRF 7.5
Angelman syndrome 7.4
delayed speech 7.4
severe mental retardation 7.3
hepatic porphyria 7.3
mitochondrial encephalomyopathy 7.1
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Symptom
tonic seizure 10.9
partial seizure 8.6
seizures 8.2
decreased appetite 7.6
drooling 7.4
sleepiness 7.1
myoclonus 7.0
tonic-clonic seizure 6.8
Poor sleep 6.7
hypotonia 6.4
dizziness 6.1
ataxic gait 6.1
hoarseness 5.6
spasm 5.5
ataxia 5.4
insomnia 5.1
eds 5.1
spasticity 5.1
anorexia 5.0
hypertonia 4.9
tingling 4.9
asthenia 4.8
hemiplegia 4.8
despair 4.5
alexithymia 4.4
neuralgia 4.4
vomiting 4.2
nausea 4.1
sore throat 3.7
headache 3.6
nausea and vomiting 3.5
cerebellar ataxia 3.4
tremor 3.3
fatigue 3.3
agitation 3.2
paresthesia 2.9
cachexia 2.7
vertigo 2.4
diarrhea 2.4
cough 2.2
dystonia 2.1
syncope 2.0
anesthesia 1.6
stigma 1.5
functional recovery 1.5
pain 0.6
dyspnea 0.4
Drug
Rufinamide 14.8
Felbatol 13.0
Topamax 11.3
Zonegran 11.0
Stiripentol 11.0
Sulthiame 10.9
Ganaxolone 10.9
Anexate 10.1
Zonisamide 9.8
Cortrosyn 9.2
Cortrosyn 9.0
Fosphenytoin 8.7
Gabapentin 8.5
Pyridoxal phosphate 8.0
Sodium valproate 7.9
Thiopentone 7.5
Pregabalin 6.4
Prednisolone 6.2
Everolimus 5.7
Zoledronic acid 5.5
DBS 5.4
Prednisone 5.2
Vitamin B 4.9
pyridoxal phosphate 4.9
9-THC 4.4
Frontal 4.2
THF 3.2
CSF 1.8
lactose 1.1
Monit 1.1
ROS 0.9
Enzyme
CYP46A1 7.7
dihydropteridine reductase 7.5
PHT 7.2
GABA transaminase 7.1
CPS 4.9
triphosphatase 4.6
sialyltransferase 4.6
sialyltransferase 4.6
sialyltransferase 4.6
CYP3A4 4.5
tryptophan hydroxylase 4.4
glutamate decarboxylase 4.1
carboxylesterase 3.6
pyruvate dehydrogenase 3.4
pyruvate dehydrogenase 3.4
enolase 3.3
P-glycoprotein 3.1
complex I 3.1
transglutaminase 2.9
glutamine synthetase 2.9
pyruvate dehydrogenase 2.8
tyrosine hydroxylase 2.3
xanthine oxidase 2.1
aspartate aminotransferase 0.8
alanine aminotransferase 0.5
ACS -0.1
catalase -0.6
superoxide dismutase -0.7
ATPase -0.8
Compound
Felbamate 12.9
Clobazam 12.4
2-phenyl-1,3-propanediol 12.2
Vigabatrin 10.8
Zonisamide 10.7
AY9944 10.7
Cannabidiol 10.5
Lamotrigine 10.4
CZP 10.4
Oxcarbazepine 10.4
Anexate 10.3
Topiramate 9.9
Triacetin 9.8
Fosphenytoin 9.5
Perfluorodecalin 9.5
BNS 9.5
Tiagabine 8.9
(+)-Amphetamine 8.8
Retigabine 8.2
Levetiracetam 8.2
4-pentenoic acid 7.9
Nitrazepam 7.5
Clonazepam 7.4
PHT 7.2
Valproic acid 7.0
Fenfluramine 6.7
Pyridoxine 6.6
MCE 6.6
Lorazepam 6.4
d-Amphetamine 6.4
Prednisolone 6.2
Flumazenil 6.2
Valproic acid 6.2
MAE 6.1
Amantadine 6.1
Tetrahydrocannabinol 6.1
Acetone 5.7
PLP 5.5
Dexmedetomidine 5.4
DBS 5.4
ACTH 5.4
Evans Blue 5.4
1-chloro-2,4-dinitrobenzene 5.2
Retard 5.1
dipropyl 4.9
HPP 4.7
APV 4.7
5-HIAA 4.7
Prednisone 4.5
Phosphatidylcholine 4.5
HVA 4.4
Luminal 4.3
GABA 4.3
GABA 4.2
gamma-aminobutyric acid 4.2
Tween 20 4.2
TRH 4.1
Neurotol 3.9
Austin 3.7
butyric acid 3.7
butyric acid 3.6
Guo 3.6
CAP 3.5
butyric acid 3.4
Verapamil 3.4
CAP 3.3
Verapamil 3.3
hydroxyindoleacetic acid 3.2
nicotinic acid 3.1
Lithium 3.0
Sodium 3.0
Guo 2.9
Hearts 2.9
NMDA 2.8
Optimal 2.7
Dexamethasone 2.6
sodium 2.4
H2S 2.3
A 3 2.3
DMF 2.1
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