Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0238111 (Lennox-Gastaut syndrome)
 861 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 67
ACTH 21
GABA 18
MRI 16
Pol 11
Rett syndrome 10
adrenocorticotropic hormone 9
AED 8
beta-endorphin 7
SCN1A 7
STXBP1 7
CYP2C19 6
CBD 6
LGS 6
cytochrome P450 6
GABRB3 6
CHD2 5
REM 5
She 5
X-linked 5
asymmetrical 5
GABRA1 4
CYP3A4 4
sodium channel 4
KCNT1 4
GTPase 3
TSC2 3
CSF 3
TSC1 3
CLB 3
DNM1 3
thyrotropin-releasing hormone 3
NMDA receptor 3
GABA transaminase 3
P-glycoprotein 3
HLA 3
GPR55 3
Thyrotropin-releasing hormone 3
IgA 2
EMX2 2
dynamin 2
mTOR 2
SCN8A 2
GABA(A) receptor 2
dynamin 1 2
GABRG2 2
GABRB2 2
BF2 2
ACS 2
tyrosine hydroxylase 2
ALG13 2
NHS 2
dihydropteridine reductase 2
THC 2
parvalbumin 2
DCX 2
XLIS 2
Mol 2
PHA 2
LIS1 2
filamin A 2
CYP3A 2
FDG 2
CDKL5 2
HBA 2
IQSEC2 2
por 2
Pur 1
SMEI 1
TNC 1
CA3 1
glutamate binding 1
KCNQ2 1
GBP 1
DHPR 1
myelo 1
DRE 1
SOD 1
NR1 1
RNS 1
5-HT1A 1
syntaxin-binding protein 1 1
voltage-gated sodium channel 1
NEDD4L 1
DNA-binding protein 1
alanine aminotransferase 1
glutamic acid decarboxylase 1
cytochrome 1
ADHD 1
glutamate receptor 1
NR2B 1
AML 1
MCM 1
SV2A 1
alternatively spliced 1
PCDH19 1
ST3GAL3 1
CACNA1A 1
SME 1
CA4 1
KPNA2 1
Chromodomain-helicase-DNA-binding protein 2 1
gamma-amino butyric acid 1
transglutaminase 1
oncogene) 1
substance P 1
methyltransferase 1
LCT 1
RYR3 1
DR5 1
glutamine synthetase 1
brain) 1
SLACK 1
Gallus gallus 1
pseudogene 1
TNF 1
MERRF 1
metallothionein 1
peroxisome proliferator-activated receptor 1
glucose transporter 1
orphan G protein-coupled receptor 1
BID 1
transcriptional repressor 1
insulin-like growth factor 1
PLS 1
zinc finger protein 1
ROS 1
CYP2B6 1
carboxylesterase 1
MEG 1
TEM 1
IRF2BPL 1
calmodulin 1
EEF1A2 1
fukutin 1
axonal 1
amyloid precursor protein 1
jerky 1
glutamate decarboxylase 1
PAO 1
FACE 1
SAF-A 1
GRIN1 1
glial fibrillary acidic protein 1
HLA-A 1
FRAP 1
endoplasmic reticulum 1
chloride channel 1
ATP 1
pyruvate dehydrogenase 1
AAS 1
brefeldin A-inhibited 1
CA1 1
MACF1 1
X-linked recessive 1
Reelin 1
cytochrome c oxidase 1
sit 1
CCT 1
ERG 1
cAMP response element binding protein 1
MELAS 1
FISH 1
aspartate aminotransferase 1
FASN 1
CLCN4 1
beta 1 1
cryptic 1
olfactory 1
ATR 1
GABRA6 1
gamma2 1
GB2 1
reserved 1
BCS 1
sialyltransferase 1
SHANK3 1
PRL 1
GPR56 1
RELN 1
GABA(B) receptor 1
acetylcholine receptor 1
KPNA7 1
ARX 1
GABRD 1
DR4 1
Nav1.1 1
ARFGEF2 1
tryptophan hydroxylase 1
ENT1 1
NDUFV2 1
FSH 1
L-type calcium channel 1
nerve growth factor 1
ubiquitin 1
G-protein-coupled receptor 1
transporter protein 1
tap 1
CAT 1
EMA 1
KCNT2 1
FAS 1
NSE 1
BCL11A 1
CPS 1
SLC9A6 1
ADP-ribosylation factor 1
CREB 1
albumin 1
brain-derived neurotrophic factor 1
hemoglobin 1
transient receptor potential vanilloid 1 1
dentatorubral-pallidoluysian atrophy 1
PURA 1
DBS 1
endostatin 1
Del 1
CAP 1
reductase 1
Cav3.1 1
enolase 1
FLNA 1
xanthine oxidase 1
COL18A1 1
Ki-67 1
helicase 1
GRIN2B 1
Fukuyama-type congenital muscular dystrophy 1
nuclear transport receptor 1
Disease
Lennox-Gastaut syndrome 861
Lennox-Gastaut syndrome 694
epilepsy 583
West 184
encephalopathy 127
Syndrome 56
status epilepticus 53
mental retardation 41
mental retardation 39
tuberous sclerosis 37
complex partial seizures 33
fits 27
juvenile myoclonic epilepsy 26
Landau-Kleffner syndrome 26
developmental delay 20
cognitive impairment 20
focal epilepsy 19
Ohtahara syndrome 19
Cannabis 17
encephalitis 15
temporal lobe epilepsy 15
petit mal 13
autism 13
rash 13
aplastic anemia 11
Rett syndrome 11
dysplasia 11
confusion 10
Down syndrome 9
Alzheimer's disease 9
multiple sclerosis 9
generalized seizure 8
cerebral palsy 8
AIC 8
depression 8
myoclonus epilepsy 8
atonic seizure 7
intellectual impairment 7
lissencephaly 7
febrile convulsions 7
aggression 7
severe mental retardation 6
LGS 6
aphasia 6
migraine 6
photosensitivity 6
diplopia 5
brain atrophy 5
SWS 5
pachygyria 5
Anterior 5
Angelman syndrome 5
brain dysfunction 4
developmental disabilities 4
hypsarhythmia 4
IGE 4
Lennox syndrome 4
hemiparesis 4
stroke 4
subacute sclerosing panencephalitis 4
tumor 4
PME 4
Best 3
LBD 3
schizencephaly 3
blindness 3
dementia 3
Intractable epilepsy 3
sleep disturbances 3
hydrocephalus 3
addiction 3
hypoglycemia 3
hamartoma 3
dysphagia 3
ketosis 3
apraxia 3
Rasmussen encephalitis 3
mutism 3
Atypical absence seizures 3
nystagmus 3
neuronal ceroid lipofuscinosis 3
psychosis 3
pneumonia 3
mental handicap 3
reflex epilepsy 3
bipolar disorder 3
Leigh syndrome 3
sleep disorders 3
Parkinson's disease 3
SME 2
Myoclonic Encephalopathy 2
ADHD 2
infectious diseases 2
systemic lupus erythematosus 2
meningitis 2
epileptic twilight state 2
ring chromosome 20 2
hypertension 2
meningoencephalitis 2
mole 2
neurological disease 2
OSX 2
prematurity 2
Creutzfeldt-Jakob disease 2
Huntington's disease 2
PHA 2
Benign neonatal seizures 2
nephrolithiasis 2
fragile X syndrome 2
LIS1 2
phenylketonuria 2
Atypical benign partial epilepsy 2
posttraumatic stress disorder 2
cancer 2
drug withdrawal 2
THC 2
acute lymphoblastic leukemia 2
anxiety disorders 2
malnutrition 2
encephalomyelitis 2
hemangioma 2
EME 2
obesity 2
mitochondrial encephalomyopathy 2
cognitive deficit 2
genetic disorder 2
ventricular dilatation 2
ABPE 2
macrocephaly 2
chronic pain 2
Epilepsy with myoclonic absences 2
frontal lobe syndrome 2
hepatitis 2
herpes simplex 2
XLIS 2
GEFS+ 2
herpes 2
NHS 2
behavior problem 2
mumps meningitis 1
Photosensitive epilepsy 1
astrocytoma 1
Lowe syndrome 1
aminoaciduria 1
Benign myoclonic epilepsy in infancy 1
Generalized epilepsy 1
renal impairment 1
grand mal epilepsy 1
Frontal lobe 1
leukemia 1
atrioventricular block 1
thalassemia 1
coma 1
lupus 1
Neonatal seizures 1
MERRF 1
autoimmune disease 1
Epileptic encephalopathy 1
dehydration 1
glaucoma 1
Common variable immunodeficiency 1
bilateral cataracts 1
hyperprolinemia 1
thrombocytopenia 1
trisomy 15q 1
renal failure 1
epilepsy; symptomatic 1
Crohn's disease 1
brain disorder 1
Other epilepsy 1
PLS 1
mitochondrial disease 1
cerebral ischemia 1
exotropia 1
bacterial meningitis 1
hyperphagia 1
celiac disease 1
brain tumor 1
varices 1
aseptic meningitis 1
Fukuyama congenital muscular dystrophy 1
vasculitis 1
Benign focal epilepsy of childhood 1
lipidosis 1
hyperphenylalaninemia 1
CNS diseases 1
schizophrenia 1
Bielschowsky 1
porphyria 1
Autism 1
orphan disease 1
irritable bowel syndrome 1
Epilepsia partialis continua 1
bronchiolitis 1
A-V malformation 1
AAS 1
mole 1
aggressiveness 1
keratomalacia 1
leukodystrophy 1
optic atrophy 1
sepsis 1
dyskinesia 1
ganglioglioma 1
anemia 1
delayed speech 1
leukoencephalopathy 1
scotoma 1
glutaric aciduria 1
EMA 1
major depressive disorder 1
Opsoclonus myoclonus 1
spastic diplegia 1
moderate mental retardation 1
leptomeningeal metastases 1
obstructive sleep apnea 1
immaturity 1
aldosteronism 1
hypohidrosis 1
Stevens-Johnson syndrome 1
prolapse 1
proteinuria 1
degenerative disease 1
Childhood epilepsy with occipital paroxysms 1
TEM 1
hyperbilirubinemia 1
TEM 1
candidiasis 1
pseudobulbar palsy 1
cardiomyopathy 1
Nonconvulsive status epilepticus 1
metachromatic leukodystrophy 1
learning disability 1
HCG 1
iron deficiency anemia 1
subarachnoid hemorrhage 1
lactic acidosis 1
muscular dystrophy 1
Japanese encephalitis 1
suicide 1
emotional instability 1
kuru 1
myasthenia gravis 1
encephalomalacia 1
sarcoidosis 1
hypogammaglobulinemia 1
Pseudotumor cerebri 1
pica 1
urolithiasis 1
behavior disorder 1
FAS 1
sepsis 1
Nodding spasm 1
Behavioral problems 1
acute leukemia 1
psychomotor epilepsy 1
tetraplegia 1
measles 1
retinoblastoma 1
profound mental retardation 1
Steroids 1
disinhibition 1
primary pulmonary hypertension 1
chronic disease 1
diabetic neuropathy 1
Disorder 1
lupus 1
Gurrieri syndrome 1
gastroenteritis 1
memory impairment 1
trigeminal neuralgia 1
Costello syndrome 1
Still 1
mental illness 1
CAP 1
cytomegalovirus 1
tyrosinemia 1
myopia 1
Myoclonic astatic epilepsy 1
Alpers 1
erythema multiforme 1
viral pneumonia 1
brain abscess 1
brachycephaly 1
trisomy 1
immunodeficiency 1
enterocolitis 1
Hepatic impairment 1
Dandy-Walker malformation 1
rheumatoid arthritis 1
immunopathology 1
Cerebellar atrophy 1
social stress 1
bends 1
SEM 1
immature personality 1
Bartter's syndrome 1
hepatic porphyria 1
Tay-Sachs disease 1
MDS 1
amaurosis 1
otitis media 1
sialidosis 1
Symptom
seizures 647
sleepiness 48
headache 18
dizziness 18
ataxia 18
vomiting 16
myoclonus 15
fatigue 14
hypotonia 13
anorexia 12
pain 11
nausea 11
tonic seizure 11
insomnia 10
anesthesia 9
spasm 9
diarrhea 8
partial seizure 7
decreased appetite 6
spasticity 6
tremor 5
hoarseness 4
tonic-clonic seizure 4
agitation 3
cough 3
hemiplegia 3
nausea and vomiting 3
drooling 3
asthenia 2
Poor sleep 1
functional recovery 1
dyspnea 1
dystonia 1
hypertonia 1
tingling 1
alexithymia 1
syncope 1
eds 1
cachexia 1
paresthesia 1
stigma 1
cerebellar ataxia 1
vertigo 1
neuralgia 1
ataxic gait 1
sore throat 1
despair 1
Drug
Rufinamide 45
Zonisamide 9
Gabapentin 9
CSF 3
Stiripentol 3
Prednisolone 3
Sodium valproate 2
Monit 2
THF 2
Felbatol 2
Topamax 2
pyridoxal phosphate 2
Pregabalin 1
ROS 1
DBS 1
Vitamin B 1
Zoledronic acid 1
Everolimus 1
Cortrosyn 1
Ganaxolone 1
Frontal 1
lactose 1
Thiopentone 1
Anexate 1
Prednisone 1
Sulthiame 1
Cortrosyn 1
9-THC 1
Pyridoxal phosphate 1
Zonegran 1
Fosphenytoin 1
Enzyme
CYP3A4 4
P-glycoprotein 3
GABA transaminase 3
dihydropteridine reductase 2
ACS 2
tyrosine hydroxylase 2
complex I 2
transglutaminase 1
enolase 1
triphosphatase 1
sialyltransferase 1
pyruvate dehydrogenase 1
ATPase 1
aspartate aminotransferase 1
CYP46A1 1
superoxide dismutase 1
pyruvate dehydrogenase 1
xanthine oxidase 1
sialyltransferase 1
sialyltransferase 1
alanine aminotransferase 1
CPS 1
carboxylesterase 1
glutamate decarboxylase 1
PHT 1
catalase 1
tryptophan hydroxylase 1
pyruvate dehydrogenase 1
glutamine synthetase 1
Compound
Clin 72
Dec 54
sodium 39
Felbamate 30
Lamotrigine 28
Clobazam 22
ACTH 22
Cannabidiol 19
GABA 18
GABA 18
Vigabatrin 17
Topiramate 15
Valproic acid 12
calcium 11
potassium 10
glucose 10
Zonisamide 9
glutamate 8
water 8
gamma-aminobutyric acid 8
acetate 7
Oxcarbazepine 7
AY9944 6
His 6
Levetiracetam 4
galactose 4
DNA 4
2-phenyl-1,3-propanediol 4
Retard 4
Neurotol 3
bromide 3
Prednisolone 3
5-HT 3
TRH 3
Optimal 3
NMDA 3
ACS 2
acetonitrile 2
butyric acid 2
fluorine 2
oxygen 2
vinyl 2
tryptophan 2
Luminal 2
Valproic acid 2
1-chloro-2,4-dinitrobenzene 2
Tiagabine 2
butyric acid 2
Sodium 2
Clonazepam 2
GTP 2
methionine 2
tryptophan 2
ACS 2
tryptophan 2
Acetone 2
tryptophan 2
acetone 2
butyric acid 2
PLP 2
CZP 2
zinc 2
Pyridoxine 1
Perfluorodecalin 1
Dexmedetomidine 1
PHT 1
H2S 1
Phosphatidylcholine 1
TSH 1
MCE 1
BNS 1
Fosphenytoin 1
hydrogen 1
Austin 1
Dexamethasone 1
nitrogen 1
Amantadine 1
phosphate 1
ethanol 1
CAT 1
PEG 1
nicotinamide 1
Lorazepam 1
dipropyl 1
chlorine 1
Nitrazepam 1
5-HIAA 1
Evans Blue 1
CAT 1
cAMP 1
Cholesterol 1
Off 1
hydroxyindoleacetic acid 1
MAE 1
Tween 20 1
Fenfluramine 1
ATP 1
Flumazenil 1
Verapamil 1
Prednisone 1
CAP 1
Anexate 1
A 3 1
TEM 1
DBS 1
(+)-Amphetamine 1
HPP 1
APV 1
hexane 1
Triacetin 1
PEG 1
CAP 1
Tetrahydrocannabinol 1
CAM 1
MDA 1
urea 1
CAT 1
Hearts 1
barium 1
d-Amphetamine 1
Guo 1
Retigabine 1
L-DOPA 1
Lithium 1
Guo 1
HVA 1
4-pentenoic acid 1
Verapamil 1
AMPA 1
DMF 1
nicotinic acid 1
glutamine 1
TNF 1
creatinine 1
acrylamide 1