Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0235886 (leg edema)
 674 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
She 66
Sep 49
serum albumin 24
albumin 19
IgA 13
C-reactive protein 12
calcium channel 10
vascular endothelial growth factor 7
MRI 7
adrenocorticotropic hormone 6
beta-endorphin 6
hemoglobin 5
myeloperoxidase 5
insulin 5
natriuretic peptide 4
protein C 4
fibrinogen 4
serum protein 4
alpha-1 antitrypsin 4
lactate dehydrogenase 4
collagen 3
ACTH 3
ESR 3
CD20 3
renin 3
chronic renal failure 3
prostate-specific antigen 3
CHOP 3
lymphoid 3
Gen 3
alkaline phosphatase 2
MEFV 2
alpha-fetoprotein 2
LHRH 2
prolactin 2
asymmetrical 2
Polymerase 2
LDH 2
APC 2
surface antigen 2
angiotensin II receptor 2
IL-6 2
alanine aminotransferase 2
CRP 2
creatine kinase 2
VEGF 2
thyroid hormone 2
IgE 2
AFP 2
BNP 2
thromboplastin 2
Spin 2
TRH 2
ANOVA 2
mTOR 2
ACE 2
interferon 2
proteinase 3 2
prostate specific antigen 2
PAP 2
CEAP 2
tyrosine kinase 2
interleukin-2 receptor 2
SS-A 2
atrial natriuretic peptide 2
FDG 2
HLA 2
axonal 2
somatostatin 2
granulocyte colony-stimulating factor 2
Albumin 2
cage 1
Myeloperoxidase 1
thyroid transcription factor-1 1
CRH 1
stromelysin 1
MLH1 1
amylase 1
CXCR3 1
Sotos syndrome 1
leukocyte antigen 1
non-Hodgkin's lymphoma 1
thymus 1
megalin 1
COP 1
interferon-alpha 1
Men 1
cathepsin G 1
interleukin-4 1
vascular endothelial growth factor A 1
SEMG 1
angiotensin II 1
PROS1 1
extracellular protein 1
AML 1
PLA 1
androgen receptor 1
cytochrome P450 1A2 1
CD103 1
alpha 1-antitrypsin 1
CBD 1
NOD 1
endothelin-1 1
MC3 1
EAD 1
ADH 1
HDR 1
vasopressin 1
protein S 1
Myoglobin 1
Alb 1
mast cell tryptase 1
IVA 1
thyroid stimulating hormone 1
fibronectin 1
P-glycoprotein 1
Lp(a) 1
gastrin 1
RNP 1
PRL 1
MTM 1
CD8 1
thrombospondin 1
SS-B 1
NAG 1
CD68 1
X-linked 1
por 1
CYP3A4 1
xCT 1
MTF 1
B12 1
CTR 1
TTR protein 1
granulocyte 1
cubilin 1
antithrombin III 1
T cell receptor 1
NIDDM 1
CD4 1
HSA 1
bcl-2 1
PSA 1
phosphatase 1
mucin 1
CEA 1
carcinoembryonic antigen 1
interferon alpha 2b 1
phospholipase A2 receptor 1
nodal 1
enigma 1
Mol 1
interleukin-6 1
CXCL9 1
c-kit 1
titin 1
interleukin 2 1
lacrimal 1
growth hormone 1
chromogranin A 1
IgA1 1
transthyretin 1
ATR 1
SCIP 1
cytochrome P450 1
reserved 1
DR5 1
calcineurin 1
FFM 1
epidermal growth factor receptor 1
parathyroid hormone 1
CD56 1
tumor necrosis factor 1
M-protein 1
HCC 1
CO2 1
AII 1
heavy chain 1
HRAS 1
cytokeratin 1
phosphomannomutase 1
RAGE 1
tap 1
ATTR 1
API 1
CD117 1
ANP 1
CPS 1
PMM2 1
platelet-derived growth factor receptor 1
IgG3 1
vimentin 1
NLRP3 1
podocin 1
sit 1
tRNA 1
serum amyloid A protein 1
endothelin receptor 1
GM-CSF 1
fused 1
gamma-glutamyltransferase 1
HELIOS 1
NMR 1
MOF 1
kit 1
rheumatoid factor 1
cytokine 1
phosphodiesterase 1
1A1 1
mineralocorticoid receptor 1
xanthine oxidase 1
IL-2 receptor 1
AGE 1
pT3 1
adenosine deaminase 1
KvLQT1 1
B19 1
vascular endothelial growth factor receptor 1
renal amyloidosis 1
TNM 1
troponin I 1
A-II 1
CYP2C9 1
BTR 1
Disease
tumor 66
heart failure 59
proteinuria 52
hypertension 52
deep vein thrombosis 41
cancer 39
nephrotic syndrome 35
lymphedema 34
venous insufficiency 26
varices 23
glomerulonephritis 23
anemia 20
metastases 20
pericarditis 18
vasculitis 17
pericardial effusion 17
diabetes 16
pulmonary embolism 15
lymphadenopathy 15
carcinoma 15
protein-losing enteropathy 14
pulmonary hypertension 14
ischemia 14
cirrhosis 13
congestive heart failure 13
obesity 13
hepatocellular carcinoma 13
hydronephrosis 13
systemic lupus erythematosus 12
amyloidosis 12
renal insufficiency 11
thrombocytopenia 11
Budd-Chiari syndrome 11
renal disease 11
membranous nephropathy 10
pneumonia 10
lymphocele 10
polyneuropathy 10
lymphoma 10
renal failure 9
rare disease 9
POEMS syndrome 8
hepatitis 8
hypothyroidism 8
gammopathy 8
rheumatoid arthritis 8
Parkinson's disease 8
pulmonary edema 8
leg ulcers 8
adenocarcinoma 8
breast cancer 8
prostate cancer 7
purpura 7
cellulitis 7
filariasis 7
Cushing's syndrome 7
tuberculosis 7
endocarditis 7
gastrointestinal disease 7
sarcoma 7
atherosclerosis 7
respiratory failure 6
cold 6
abdominal aortic aneurysm 6
chronic stable angina 6
hepatitis C 6
myocardial infarction 6
gangrene 6
multiple myeloma 6
portal hypertension 6
leiomyosarcoma 6
cystitis 6
B-cell lymphoma 6
esophageal varices 6
ureter 6
infectious diseases 6
squamous cell carcinoma 5
antiphospholipid syndrome 5
sleep apnea 5
neuropathy 5
stroke 5
compartment syndrome 5
arthritis 5
eosinophilia 5
type 2 diabetes 5
malnutrition 5
liver disease 5
hallucinations 5
confusion 5
nephritis 5
beriberi 5
lupus nephritis 5
depression 5
hepatitis B 5
dysplasia 5
lupus 5
incontinence 5
ventricular septal defect 5
stasis dermatitis 5
prostatic adenocarcinoma 5
peripheral vascular disease 4
mitral regurgitation 4
yellow nail syndrome 4
chronic obstructive pulmonary disease 4
lupus 4
asthma 4
Kaposi's sarcoma 4
sepsis 4
sepsis 4
acute renal failure 4
thymoma 4
coronary artery disease 4
lymphopenia 4
erysipelas 4
malabsorption 4
disseminated intravascular coagulation 4
lung metastases 4
heart disease 4
chronic hepatitis 4
AA amyloidosis 4
ventricular hypertrophy 4
glomerulosclerosis 4
right heart failure 4
renal impairment 4
hyperthyroidism 4
aortic aneurysm 4
pruritus 4
atrioventricular block 4
rash 4
leukopenia 4
proctitis 4
cervical cancer 4
hypoglycemia 4
lymphatic vessels 4
uveitis 3
wasting 3
renal cell carcinoma 3
Klippel-Trenaunay syndrome 3
intermittent claudication 3
cardiac tamponade 3
skin disease 3
hydrocele 3
elephantiasis 3
cardiomyopathy 3
adenoma 3
coagulopathy 3
postphlebitic syndrome 3
mesothelioma 3
plaque 3
primary tumor 3
hyperphagia 3
familial Mediterranean fever 3
thiamine deficiency 3
hyperlipidemia 3
peripheral neuropathy 3
hyperglycemia 3
peritonitis 3
sarcoidosis 3
thrombophlebitis 3
Takayasu 3
Hodgkin's disease 3
HIV 3
PSS 3
Prostate Cancer 3
chronic renal failure 3
venous stasis 3
scoliosis 3
scrotum 3
claudication 3
bone metastases 3
pancytopenia 3
tumor progression 3
hernia 3
polyposis 3
colon cancer 3
diplopia 3
acute myeloid leukemia 3
liposarcoma 3
chylothorax 3
hypercortisolism 3
osteoporosis 3
tricuspid regurgitation 3
Wuchereria 3
preeclampsia 3
leiomyoma 3
pleurisy 3
uropathy 3
Thoracic 3
Leiomyosarcoma 3
glomerulopathy 3
monoclonal gammopathy of undetermined significance 3
metabolic alkalosis 2
dyskinesia 2
empyema 2
IVC obstruction 2
Hepatocellular carcinoma 2
Colon 2
adrenocortical carcinoma 2
incontinence 2
enteropathy 2
carcinoma of the cervix 2
insulinoma 2
vagina 2
hypertrophic cardiomyopathy 2
Aortocaval fistula 2
popliteal aneurysm 2
CREST 2
Pulmonary arterial hypertension 2
TSH deficiency 2
venous disease 2
false aneurysm 2
intertrigo 2
Infection 2
dementia 2
Fanconi syndrome 2
adrenal insufficiency 2
immunodeficiency 2
bladder cancer 2
impotence 2
SLE 2
obstructive sleep apnea 2
alcoholic cirrhosis 2
osteomyelitis 2
scleroderma 2
aggression 2
ventricular fibrillation 2
Shoshin beriberi 2
Cardiovascular beriberi 2
Klippel 2
dermatitis 2
multicentric Castleman's disease 2
malignant mesothelioma 2
polyarteritis nodosa 2
dermatomyositis 2
Proteinuria 2
graft-versus-host disease 2
autoimmune hemolytic anemia 2
APC 2
mitral stenosis 2
Constrictive pericarditis 2
liver cancer 2
endometrial cancer 2
cytomegalovirus 2
gastrointestinal stromal tumor 2
cystic fibrosis 2
hyperinsulinemia 2
plasmacytosis 2
cryoglobulinemia 2
aortic regurgitation 2
pulmonary tuberculosis 2
right bundle branch block 2
lymphangitis 2
ACTH-dependent Cushing's syndrome 2
essential hypertension 2
neutropenia 2
disorientation 2
encephalopathy 2
petechiae 2
ileus 2
nephrosclerosis 2
tumor lysis syndrome 2
azotemia 2
bronchiectasis 2
nephrosis 2
parkinsonism 2
pancreatitis 2
Colon 2
collagen disease 2
Colon 2
endometriosis 2
influenza 2
Raynaud's phenomenon 2
primary pulmonary hypertension 2
collagen disease 2
angioendotheliomatosis 2
gastric cancer 2
AL amyloidosis 2
recurrent cervical cancer 2
uremia 2
connective tissue disease 2
hepatic coma 2
hepatic encephalopathy 2
interstitial pneumonia 2
myocarditis 2
liver fibrosis 2
urethra 2
bacterial infection 2
hemiparesis 2
chondrosarcoma 2
hypercortisolemia 2
myelodysplastic syndrome 2
myelosuppression 2
left ventricular failure 2
myasthenia gravis 2
Primary intestinal lymphangiectasia 2
worms 2
atrial septal defect 2
osteoarthritis 2
adrenal mass 2
hemangioma 2
myopathy 2
polycystic kidney 2
sinus tachycardia 2
plasmacytoma 2
carcinoid 2
urticaria 2
prolapse 2
mononeuritis 2
Graves' disease 2
rectal cancer 2
hemolytic anemia 2
adrenal adenoma 1
basal cell carcinoma 1
HCC 1
ARF 1
paroxysmal supraventricular tachycardia 1
bronchogenic carcinoma 1
Castleman's disease 1
lung carcinoma 1
non-small cell lung cancer 1
more...
Symptom
leg edema 674
dyspnea 80
pain 49
fatigue 28
abdominal pain 26
weakness 23
diarrhea 21
exertional dyspnea 14
chest pain 14
hypoproteinemia 11
shortness of breath 11
dizziness 11
hepatomegaly 11
headache 11
sleepiness 10
discomfort 10
discomfort 10
angina 9
numbness 9
orthopnea 8
erythema 7
Ill 6
anorexia 6
arthralgia 6
flushing 6
vomiting 6
hepatosplenomegaly 6
nausea 6
abdominal fullness 5
back pain 5
cough 5
leg pain 5
cyanosis 5
regurgitation 4
lightheadedness 4
syncope 3
Cushingoid 3
fever of unknown origin 3
paresthesia 3
asthenia 3
flank pain 3
Cushingoid 3
hot flushes 3
anesthesia 3
pedal edema 3
oliguria 3
dysuria 2
blurred vision 2
chyluria 2
tingling 2
pelvic pain 2
myalgia 2
hip pain 2
respiratory distress 2
hemoptysis 2
overweight 2
polyuria 2
rales 2
pleuritic chest pain 2
groin pain 2
abdominal discomfort 2
low back pain 2
epigastric pain 2
rhinorrhea 1
dysesthesia 1
dysarthria 1
presyncope 1
paresis 1
localized edema 1
emaciation 1
neuralgia 1
excessive sweating 1
memory loss 1
tachypnea 1
collapse 1
workaholic 1
prostatism 1
HSA 1
livedo 1
hypercapnia 1
night sweats 1
knee pain 1
hypothermia 1
cancer pain 1
chills 1
polydipsia 1
lethargy 1
menopausal symptoms 1
muscle cramps 1
Pain at rest 1
sciatica 1
shoulder pain 1
clonus 1
tense 1
swollen leg 1
limb pain 1
persistent cough 1
clubbing 1
hypotonia 1
nausea and vomiting 1
snoring 1
splenomegaly 1
Orthostasis 1
Drug
Dermatol 16
Cardiovasc 15
nitroglycerin 4
Prednisolone 3
Rituximab 3
Methylprednisolone 3
Serum albumin 2
Monit 2
Albumin 2
Portal 2
CTX 2
Lipiodol 1
Clobetasol propionate 1
Triclosan 1
Plaquenil 1
Plaquenil 1
Felodipine 1
Ketoconazole 1
Bortezomib 1
Tocilizumab 1
Bosentan 1
Dial 1
Asthma 1
NAG 1
Isradipine 1
Pramipexole 1
Imatinib 1
Jujube 1
Nephron 1
Cilnidipine 1
IPM 1
caffeine 1
Fluconazole 1
CDZM 1
Mizoribine 1
Herceptin 1
MOF 1
Rosiglitazone 1
Pramipexole 1
Lenalidomide 1
Amifostine 1
CSF 1
Bosentan 1
lysine 1
Tacrolimus 1
Nelumbo seed 1
Nephron 1
Enzyme
APC 6
peroxidase 5
lactate dehydrogenase 4
ACE 3
prostate-specific antigen 3
renin 3
alanine aminotransferase 3
thromboplastin 2
alkaline phosphatase 2
creatine kinase 2
CYP3A4 1
phosphodiesterase 1
alcohol dehydrogenase 1
cathepsin G 1
Alternating 1
phosphomannomutase 1
gamma-glutamyl transpeptidase 1
trypsin 1
tryptase 1
ADH 1
adenosine deaminase 1
xanthine oxidase 1
CPS 1
HDR 1
phospholipase A2 1
P-glycoprotein 1
succinate dehydrogenase 1
calcineurin 1
adenosine deaminase 1
Compound
Clin 61
Dec 52
His 27
Cardiol 26
creatinine 18
water 18
DNA 13
calcium 12
oxygen 7
potassium 7
Mibefradil 6
glucose 6
sodium 5
urea 5
A 71 4
aldosterone 4
Spironolactone 3
Congo red 3
ACTH 3
A 42 3
Isoproterenol 3
Prednisolone 3
Methylprednisolone 3
CTX 2
PAP 2
ANCA 2
PAP 2
prostacyclin 2
acetate 2
silver 2
ethanol 2
BNP 2
arginine 2
salt 2
iodine 2
TRH 2
Nifedipine 2
PAP 2
nitrate 2
PAS 2
Octreotide 2
PAP 2
Amlodipine 2
nitrogen 2
fluorine 2
FK506 1
selenium 1
Ketoconazole 1
Luminal 1
tryptophan 1
Tegafur 1
pentadecanoic acid 1
CBDCA 1
Heparin 1
THE 1
Salix 1
Amifostine 1
nitric oxide 1
coenzyme Q10 1
mercury 1
6-12 1
Warfarin 1
PLA 1
5-FU 1
Hematoxylin 1
galactose 1
noradrenaline 1
Rifampicin 1
Ketanserin 1
Aristolochic acid 1
acetic acid 1
Flavonoid 1
Propranolol 1
pentadecanoic acid 1
AGE 1
Ropinirole 1
Nisoldipine 1
Rutin 1
caffeine 1
homocysteine 1
Thiamine 1
retinol 1
L-DOPA 1
Tegafur 1
Rapamycin 1
CBDCA 1
sulfate 1
DTPA 1
tryptophan 1
tryptophan 1
Pergolide 1
Ergot 1
Dial 1
Guo 1
carbonate 1
tryptophan 1
3TC 1
MDA 1
Guo 1
CO2 1
DSM 1
Cyclosporine 1
chromium 1
lysine 1
Propranolol 1
TNM 1
Pac 1
TSH 1
alcohol dehydrogenase 1
Methimazole 1
phosphate 1