Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0235886 (leg edema)
 674 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
TTR protein 10.0
SEMG 9.7
HELIOS 9.4
CEAP 8.9
alpha-1 antitrypsin 8.8
MTM 8.7
interferon alpha 2b 8.7
PROS1 8.6
PMM2 8.4
phosphomannomutase 7.8
phospholipase A2 receptor 7.7
SCIP 7.6
serum amyloid A protein 7.6
Sotos syndrome 7.5
MEFV 7.5
cubilin 7.4
cytochrome P450 1A2 7.4
KvLQT1 7.4
EAD 7.3
ATTR 7.0
SS-A 6.9
MTF 6.9
mast cell tryptase 6.7
thyroid transcription factor-1 6.4
FFM 6.4
xCT 6.4
SS-B 6.2
MC3 6.2
Myoglobin 6.1
Alb 6.1
podocin 6.1
adrenocorticotropic hormone 5.9
HDR 5.9
leukocyte antigen 5.9
She 5.8
BNP 5.7
NAG 5.7
HRAS 5.7
megalin 5.7
M-protein 5.7
CPS 5.6
pT3 5.5
AGE 5.5
COP 5.4
interleukin-2 receptor 5.4
renal amyloidosis 5.3
CD103 5.3
CTR 5.3
IgA1 5.2
prostate specific antigen 5.2
CBD 5.2
PAP 5.1
proteinase 3 5.1
A-II 5.0
RAGE 5.0
AFP 5.0
Myeloperoxidase 4.9
angiotensin II receptor 4.9
calcium channel 4.9
protein C 4.9
serum protein 4.8
extracellular protein 4.8
BTR 4.8
stromelysin 4.8
CHOP 4.7
titin 4.7
CXCL9 4.7
cathepsin G 4.7
gamma-glutamyltransferase 4.6
Spin 4.6
platelet-derived growth factor receptor 4.6
serum albumin 4.6
ANP 4.6
IVA 4.6
Albumin 4.5
natriuretic peptide 4.5
C-reactive protein 4.5
AII 4.5
1A1 4.4
ADH 4.4
CXCR3 4.4
NIDDM 4.4
troponin I 4.3
MLH1 4.3
DR5 4.3
ESR 4.3
RNP 4.3
prostate-specific antigen 4.3
IgA 4.2
enigma 4.2
TRH 4.2
CRH 4.1
B19 4.1
CD20 4.1
thyroid stimulating hormone 4.1
HSA 4.0
CYP2C9 4.0
endothelin receptor 4.0
CD117 4.0
Lp(a) 4.0
alpha 1-antitrypsin 4.0
HCC 4.0
chromogranin A 4.0
MOF 4.0
albumin 3.9
myeloperoxidase 3.9
atrial natriuretic peptide 3.8
mineralocorticoid receptor 3.8
vascular endothelial growth factor A 3.8
beta-endorphin 3.8
vascular endothelial growth factor receptor 3.7
granulocyte colony-stimulating factor 3.7
transthyretin 3.7
protein S 3.6
alpha-fetoprotein 3.6
CRP 3.6
IL-2 receptor 3.6
APC 3.6
thrombospondin 3.5
NLRP3 3.5
ACE 3.5
vascular endothelial growth factor 3.4
thromboplastin 3.4
chronic renal failure 3.4
Polymerase 3.4
API 3.3
adenosine deaminase 3.2
rheumatoid factor 3.2
LDH 3.2
interferon-alpha 3.1
LHRH 3.1
PSA 3.1
CEA 3.1
antithrombin III 3.1
FDG 3.1
sit 3.1
CD68 3.1
PRL 3.0
lacrimal 3.0
asymmetrical 3.0
interleukin-4 2.9
interleukin 2 2.9
CYP3A4 2.9
surface antigen 2.9
CD56 2.9
ATR 2.9
lactate dehydrogenase 2.9
c-kit 2.8
NOD 2.8
ACTH 2.8
alanine aminotransferase 2.8
IgG3 2.7
creatine kinase 2.7
bcl-2 2.7
fibrinogen 2.6
AML 2.6
TNM 2.6
VEGF 2.5
thyroid hormone 2.5
carcinoembryonic antigen 2.5
more...
Disease
Lymph node fibrosis 15.5
Inferior vena cava stenosis 13.5
Cardiovascular beriberi 13.4
Disseminated nocardiosis 12.9
Shunt nephritis 12.9
Popliteal entrapment syndrome 12.7
Shoshin beriberi 12.1
cellulitis of the leg 11.9
Intestinal capillariasis 11.9
Primary intestinal lymphangiectasia 11.4
Aortocaval fistula 11.0
stasis dermatitis 10.6
Functional tricuspid regurgitation 10.5
IVC obstruction 10.5
yellow nail syndrome 10.3
postmastectomy lymphedema 10.0
Lymphangioma circumscriptum 9.9
lymphocele 9.8
postphlebitic syndrome 9.7
beriberi 9.7
TSH deficiency 9.6
ACTH-dependent Cushing's syndrome 9.5
blind loop syndrome 9.5
classic Kaposi's sarcoma 9.5
Polycystic liver disease 9.5
Secondary lymphedema 9.3
protein-losing enteropathy 9.3
first degree atrioventricular block 9.3
Primary cutaneous amyloidosis 9.2
intertrigo 9.2
popliteal aneurysm 9.2
POEMS syndrome 9.1
venous insufficiency 9.0
Constrictive pericarditis 9.0
proctosigmoiditis 8.9
capillariasis 8.9
Purulent pericarditis 8.9
Abdominal compartment syndrome 8.8
Intravenous leiomyomatosis 8.8
chronic stable angina 8.6
heavy chain disease 8.6
Medullary carcinoma 8.5
Budd-Chiari syndrome 8.5
recurrent cervical cancer 8.4
metastatic cervical cancer 8.4
Cronkhite-Canada syndrome 8.4
Hypereosinophilic syndrome 8.4
lymphedema 8.4
Chronic venous insufficiency 8.3
angioendotheliomatosis 8.3
Dent's disease 8.3
spermatocele 8.2
lobular breast carcinoma 8.2
tubulovillous adenoma 8.2
AA amyloidosis 8.2
disuse osteoporosis 8.2
locally advanced cancer 8.1
Leiomyosarcoma 8.1
Menetrier's disease 8.1
elephantiasis 7.9
Chemoradiation 7.9
onychodystrophy 7.8
Prinzmetal 7.8
DORV 7.7
erysipelas 7.7
collagen disease 7.7
Bronchiolitis obliterans organizing pneumonia 7.6
chronic cystitis 7.6
Klippel-Trenaunay syndrome 7.6
mononeuritis 7.6
drug-induced hepatitis 7.5
multicentric Castleman's disease 7.5
diffuse goiter 7.5
hypercortisolemia 7.5
Peripartum cardiomyopathy 7.4
collagen disease 7.4
squamous cell carcinoma of the penis 7.4
proctitis 7.4
hepatic coma 7.4
lymphangitis 7.4
pericarditis 7.4
nephrotic syndrome 7.4
Interstitial fibrosis 7.4
xanthomatosis 7.3
pericardial effusion 7.3
impulse control disorder 7.3
Klippel 7.3
EAD 7.3
intestinal tuberculosis 7.3
deep vein thrombosis 7.3
plasmacytosis 7.3
gammopathy 7.3
Ureteral obstruction 7.3
membranous nephropathy 7.3
Kimura's disease 7.2
Sotos syndrome 7.1
venous stasis 7.1
Abdomen 7.1
leg ulcers 7.1
metastatic ovarian cancer 7.1
CREST 7.0
tuberculous pleurisy 7.0
pancreatic neoplasm 7.0
hydrocele 7.0
SIADH 7.0
tumor lysis syndrome 7.0
thiamine deficiency 6.9
Lymphatic filariasis 6.8
nephrosclerosis 6.8
skin hypersensitivity 6.8
hydronephrosis 6.8
rheumatic mitral stenosis 6.7
gastrointestinal dysfunction 6.7
gastrointestinal disease 6.7
venous disease 6.7
proteinuria 6.7
acute pericarditis 6.7
filariasis 6.7
varices 6.6
angioimmunoblastic T-cell lymphoma 6.6
endomyocardial fibrosis 6.6
testicular seminoma 6.6
Wuchereria 6.6
monoclonal gammopathy of undetermined significance 6.5
anhidrosis 6.5
panuveitis 6.5
prostatic adenocarcinoma 6.5
metastatic colon cancer 6.5
Deep vein thrombosis 6.5
AL amyloidosis 6.5
pleurisy 6.4
chylothorax 6.4
adrenal mass 6.3
uropathy 6.3
vascular obstruction 6.3
false aneurysm 6.3
familial Mediterranean fever 6.3
rhabdomyoma 6.3
cellulitis 6.3
diastolic hypertension 6.3
Heparin-induced thrombocytopenia 6.3
thyroid disorder 6.3
esophageal varices 6.3
glomerulonephritis 6.2
sinus tachycardia 6.2
gangrene 6.2
compartment syndrome 6.2
chest infection 6.1
Cushing's syndrome 6.1
Pulmonary arterial hypertension 6.1
cystitis 6.1
purpura 6.1
hypercortisolism 6.1
petechiae 6.0
tinea pedis 6.0
Takayasu 5.9
nephrosis 5.9
adrenal adenoma 5.9
intermittent claudication 5.9
polyneuropathy 5.9
more...
Symptom
leg edema 15.5
workaholic 10.7
Orthostasis 10.4
swollen leg 9.7
orthopnea 9.7
pedal edema 9.4
Cushingoid 9.4
Cushingoid 9.3
abdominal fullness 9.2
Pain at rest 9.1
chyluria 8.9
hypoproteinemia 8.8
localized edema 8.8
lightheadedness 8.5
exertional dyspnea 7.6
prostatism 7.4
pleuritic chest pain 7.3
rales 7.2
dyspnea 7.1
groin pain 7.0
leg pain 6.9
hot flushes 6.8
shortness of breath 6.6
hepatomegaly 6.5
numbness 6.4
excessive sweating 6.4
presyncope 6.3
persistent cough 6.3
oliguria 6.3
tingling 6.2
limb pain 6.1
fever of unknown origin 6.1
flank pain 6.0
hepatosplenomegaly 6.0
clonus 6.0
cyanosis 6.0
livedo 5.8
abdominal discomfort 5.8
dizziness 5.7
asthenia 5.7
clubbing 5.7
hip pain 5.7
muscle cramps 5.7
dysesthesia 5.6
blurred vision 5.5
emaciation 5.5
flushing 5.5
night sweats 5.3
arthralgia 5.3
abdominal pain 5.3
dysuria 5.3
chest pain 5.3
sleepiness 5.2
polyuria 5.0
sciatica 4.9
menopausal symptoms 4.9
weakness 4.8
paresthesia 4.8
epigastric pain 4.8
neuralgia 4.8
fatigue 4.7
Ill 4.7
erythema 4.7
pelvic pain 4.5
regurgitation 4.5
tense 4.4
polydipsia 4.4
discomfort 4.4
rhinorrhea 4.4
anorexia 4.4
angina 4.3
back pain 4.3
discomfort 4.3
tachypnea 4.2
diarrhea 4.1
shoulder pain 4.1
knee pain 4.1
snoring 4.0
HSA 4.0
hemoptysis 3.9
cancer pain 3.9
syncope 3.9
myalgia 3.8
memory loss 3.7
dysarthria 3.6
nausea 3.6
chills 3.5
cough 3.3
low back pain 3.2
headache 3.2
vomiting 3.2
pain 3.1
lethargy 3.1
paresis 3.0
hypotonia 3.0
hypercapnia 2.6
nausea and vomiting 2.3
respiratory distress 2.3
splenomegaly 2.3
overweight 1.8
hypothermia 1.4
collapse 0.7
anesthesia 0.4
Drug
Nelumbo seed 15.5
CDZM 10.5
Plaquenil 10.2
Plaquenil 10.1
Jujube 9.4
Cilnidipine 9.1
Mizoribine 8.9
Clobetasol propionate 8.3
Pramipexole 7.8
Pramipexole 7.8
Isradipine 7.5
Methylprednisolone 7.3
Amifostine 7.0
Felodipine 7.0
Bosentan 6.8
Bosentan 6.8
Tocilizumab 6.8
Prednisolone 6.6
Serum albumin 6.3
Lenalidomide 6.2
Rosiglitazone 5.9
Lipiodol 5.8
Rituximab 5.6
Ketoconazole 5.5
Fluconazole 5.2
IPM 5.0
Bortezomib 5.0
Triclosan 4.9
Tacrolimus 4.8
Portal 4.5
NAG 4.5
nitroglycerin 4.4
Herceptin 4.4
Albumin 4.3
Imatinib 4.2
MOF 4.0
CTX 3.2
Nephron 2.0
Cardiovasc 1.8
Dermatol 1.5
Monit 1.4
Nephron 1.4
caffeine 1.1
Asthma 0.9
Dial 0.6
CSF 0.6
lysine -0.3
Enzyme
phosphomannomutase 7.6
HDR 6.3
CPS 5.2
Alternating 4.9
cathepsin G 4.7
ADH 4.4
prostate-specific antigen 4.3
APC 4.1
tryptase 4.1
adenosine deaminase 3.2
adenosine deaminase 3.2
ACE 3.0
CYP3A4 2.9
thromboplastin 2.8
lactate dehydrogenase 2.7
succinate dehydrogenase 2.5
xanthine oxidase 2.5
alanine aminotransferase 2.4
gamma-glutamyl transpeptidase 2.4
alcohol dehydrogenase 2.3
creatine kinase 2.3
renin 2.0
peroxidase 1.9
P-glycoprotein 1.8
phospholipase A2 1.7
calcineurin 1.5
phosphodiesterase 1.3
alkaline phosphatase 1.0
trypsin 0.2
Compound
Mibefradil 10.7
Ropinirole 8.8
Pergolide 8.3
Aristolochic acid 7.8
Tegafur 7.7
Spironolactone 7.6
Nisoldipine 7.6
Ergot 7.5
Methylprednisolone 7.4
Amlodipine 7.2
Methimazole 7.1
Tegafur 7.0
Amifostine 7.0
pentadecanoic acid 6.9
pentadecanoic acid 6.8
Prednisolone 6.6
Octreotide 6.6
A 71 6.4
Flavonoid 6.2
Ketanserin 6.0
Rutin 5.7
BNP 5.7
ANCA 5.7
A 42 5.6
AGE 5.6
Ketoconazole 5.5
Thiamine 5.3
Congo red 5.2
PAP 5.1
CBDCA 5.1
CBDCA 5.1
Nifedipine 5.0
3TC 4.9
PAP 4.9
PAP 4.9
PAP 4.8
Rifampicin 4.5
Isoproterenol 4.4
coenzyme Q10 4.3
Hematoxylin 4.2
Warfarin 4.2
His 4.0
Guo 3.9
PAS 3.9
TRH 3.9
creatinine 3.8
Rapamycin 3.8
Luminal 3.6
Salix 3.6
THE 3.6
Propranolol 3.5
Propranolol 3.5
Guo 3.3
CTX 3.2
Cyclosporine 3.2
FK506 3.0
aldosterone 2.9
PLA 2.9
ACTH 2.9
Heparin 2.8
prostacyclin 2.8
DTPA 2.8
5-FU 2.7
6-12 2.7
TNM 2.6
alcohol dehydrogenase 2.5
fluorine 2.4
Cardiol 2.4
L-DOPA 2.4
retinol 2.2
homocysteine 2.0
urea 1.9
potassium 1.8
TSH 1.6
chromium 1.4
caffeine 1.1
selenium 1.0
MDA 1.0
iodine 0.9
Clin 0.9
nitrate 0.8
DSM 0.8
mercury 0.8
calcium 0.8
carbonate 0.7
silver 0.7
Dial 0.6
noradrenaline 0.5
Pac 0.5
tryptophan 0.4
tryptophan 0.4
acetic acid 0.4
tryptophan 0.4
water 0.3
Dec 0.2
tryptophan 0.2
arginine -0.0
glucose -0.1
oxygen -0.2
sodium -0.2
salt -0.3
acetate -0.3
DNA -0.4
ethanol -0.6
galactose -0.7
nitrogen -0.7
lysine -0.8
CO2 -0.9
nitric oxide -1.1
sulfate -1.2
phosphate -1.9