Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0235886 (leg edema)
 674 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 21 year-old woman was admitted to our hospital due to congestive heart failure with severe leg edema. A continuous murmur was heard around the lumbar spine close to a surgical scar after laminectomy of the L4-L5 and L5-S1 disc that the patient had undergone six months before. Aortography demonstrated an arteriovenous fistula between the right common iliac artery and the inferior vena cava. At operation, we found the moderate sized venous defect and it corresponded with the angiographic finding. It was repaired by direct suture from inner side of the right common iliac artery. Arterial reconstruction was made with a 8mm woven dacron graft. Postoperative course was uneventful. The cardiac silhouette diminished in size and cardiac output improved from 12.5l/min. to 8l/min. after surgery. This report is the fourth case of successful repair for the arteriovenous fistula after disc surgery in Japan.
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PMID:[Surgical experience in arteriovenous fistula following disk surgery]. 371 86

A 21-year-old man was admitted to our hospital because of leg edema. Because laboratory findings revealed massive proteinuria and hypoproteinemia, he was diagnosed as having nephritic syndrome caused by minimal change disease. He was given a continuous heparin infusion and intravenous steroid therapy, at a prednisolone dose of 1 mg/kg per day, and his condition gradually improved. Five months after discharge, the patient's proteinuria relapsed. He was readmitted to our hospital and we restarted anticoagulant treatment with intravenous heparin and 60 mg prednisolone. On the third hospital day, he complained of chest pain with sudden onset and dyspnea. He quickly developed shock and died. The findings of an autopsy confirmed the presence of diffuse fibrin thrombi in bilateral pulmonary arteries, and we diagnosed the cause of death as diffuse pulmonary artery thrombosis. A coagulation test for activated partial thromboplastin time (aPTT) had already shown that aPTT was prolonged before the initiation of treatment. There may have been a deficit of antithrombin III (ATIII) - a cofactor of heparin - because of the proteinuria; thus, the continuous heparin treatment might not have been effective for the prevention of thrombosis. Alternatives to heparin treatment that do not suppress AT III, such as nafamostat mesilate or argatroban, which do not require the presence of AT III for their anticoagulant action, should be considered in cases similar to the that in the patient reported here. In patients with nephrotic syndrome who exhibit altered coagulation test results, the choice of anticoagulation therapy for treatment of the hypercoagulabilty status associated with nephrotic syndrome should be carefully considered.
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PMID:Fatal diffuse pulmonary arterial thrombosis as a complication of nephrotic syndrome. 1808 94

A 21-year-old patient, in her first and regularly controlled uneventful pregnancy, was admitted to hospital due to lower leg edema, hypertension, proteinuria, and weight gain. Fetal death occurred the next day and a female nonhydropic fetus, 40 cm CH, 1460 grams, at 29-week gestation was delivered. An autopsy showed no visible gross abnormalities except in the heart. The heart was enlarged, with five intramural and subendocardial nodules, 0.3 to 1 cm in size, three in the left ventricular free wall, and one in the right ventricle and right atrium, sharply demarcated, reddish-gray, moderately firm, with the typical appearance of rhabdomyoma.
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PMID:Intrauterine fetal death due to cardiac rhabdomyomas. 2184 54