Gene/Protein
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Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
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Enzyme
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Target Concepts:
Gene/Protein
Disease
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Query: UMLS:C0235886 (
leg edema
)
674
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin disorders) is a rare multisystemic disease associated with plasma cell dyscrasia. A 68-year-old woman with
chronic renal insufficiency
and arterial hypertension included in her medical history was admitted to the hospital with confusion, somnolence and asthenia. She presented ascites, hepatosplenomegaly,
leg oedema
, distal dysesthesias, leuconychia and multiple nodular purple red angiomas on the trunk, upper limbs and fingers. Hypothyroidism was revealed in the laboratory investigations and monoclonal IgG peak in immunoelectrophoresis. Electromyography showed both demyelinisating and axonal degenerative neuropathy. The diagnosis of POEMS syndrome was based on the dermatopathological examination of a cutaneous angioma; histology revealed features of glomeruloid angioma, a specific marker of this syndrome.
...
PMID:POEMS syndrome revealed by multiple glomeruloid angiomas. 1207 35
