Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0235886 (leg edema)
 674 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Systemic causes of leg edema include idiopathic cyclic edema, heart failure, cirrhosis, nephrosis and other hypoproteinemic states. Lymphedema may be primary, or secondary to neoplasm, lymphangitis, retroperitoneal fibrosis and, rarely (in the U.S.), filariasis. Thrombophlebitis and chronic venous insufficiency are not uncommon causes. Finally, infection, ischemia, lipedema, vascular anomalies, tumors and trauma can be responsible for the swollen leg.
 ...
PMID:The swollen leg. 18 30

Peripheral lymphedema can be induced experimentally by obliteration or destruction of the veins and/or lymphatics, extirpation of the lymph nodes and occlusion of lymphatics, circular incision of the soft tissues, experimentally induced thrombophlebitis and by simultaneous traumatization of the veins and lymphatics. Our own animal experiments were designed to provoke leg edema after ligation of the femoral vein and/or accompanying lymphatics below the inguinal ligament. In 23 animals, only one ligature of the femoral vein was applied, below the inguinal ligament and in 12 animals all accompanying lymphatics were ligated in addition. In all animals, the leg circumferences were measured in three precisely fixed positions before the experiments and daily for 22 days during the experiment. The greatest increase in circumference was found in the lower leg irrespective of the time of measurement. The peak increase of circumference was between the third and sixth day after the operation. Permanent lymph edema has not developed in any of the animals. At the latest after three weeks, the leg circumference has normalized. Additional ligation of the lymphatics merely led to a nonsignificant increase in circumference and to displacement of the maximum point by two to three days. Immediately after the operation, phlebographic and lymphographic control investigations were carried out in all animals.
 ...
PMID:[Secondary leg edema--experimental study]. 324 61

To assess the operative morbidity, we reviewed retrospectively 101 groin dissections performed in 67 patients for management of squamous cell carcinoma of the penis. No patients died, but only 18 per cent experienced no postoperative complications. Early complications included flap necrosis in 50 per cent, seroma in 16 per cent, wound infection in 14 per cent, lymphocele in 9 per cent, and thrombophlebitis in 6 per cent. Leg edema developed in 50 per cent of those operated on and remained severe in about one third of these. The frequency of complications has changed little over the thirty-five-year time span of the study and is not related to the extent of the surgical procedure. In view of the high operative morbidity, caution should be exercised against using the surgical procedure injudiciously.
 ...
PMID:Complications of groin dissection in penile cancer. Experience with 101 lymphadenectomies. 648 89