Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0235886 (leg edema)
 674 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pregnancy carries significant physiological changes that demand more cardiac output, so structural cardiac disease can cause life-threatening complications. A woman had rheumatic mitral stenosis and underwent mitral valve replacement (MVR) with bioprosthesis 8 years prior to admission. She presented with dyspnea and leg edema at 30 weeks of gestation. Severe mitral stenosis caused by xenograft failure was noted on echocardiography. Management was conservative until a sudden onset of hemodynamic compromise requiring emergency redo MVR under normothermic cardiopulmonary bypass with intra-aortic balloon pump. Monitoring of fetal heartbeat and uterine contractions showed no significant abnormalities and the woman gave birth to a full-term baby by Cesarean section with postoperative warfarin therapy.
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PMID:Emergency redo mitral valve replacement in a pregnant woman at third trimester: case report and literature review. 1872 40

A 76-year-old woman with a history of severe mitral valve stenosis had undergone mitral valve replacement with a 27 mm St. Jude Medical (SJM) valve in 1991. Follow-up transthoracic echocardiography revealed an increase in the pressure gradient across the mitral prosthesis 16 years after the surgery. Prosthetic valve dysfunction was suspected, but transesophageal echocardiography and cineradiography failed to show mechanical valve dysfunction. Two years later, she presented with dyspnea on exertion and leg edema. Cineradiography revealed intermittent restriction of the opening of the mechanical valve leaflet approximately every 10 beats. Thus, we diagnosed intermittent prosthetic valve dysfunction and performed a reoperation. On inspection of the prosthesis, we observed semicircular pannus formation around the posterior leaflet in the ventricular side. It was considered that the pannus tissue had interfered with 1 leaflet opening of the mitral valve prosthesis, resulting in intermittent valve dysfunction. We replaced the prosthesis with a new 25 mm SJM valve. The patient was discharged after confirmation of normal prosthetic function.
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PMID:[Intermittent opening of a mechanical mitral valve prosthesis due to pannus formation; report of a case]. 2159 46