Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0235632 (loin pain)
 325 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Between 1985 and 1987 102 children, age 0-14 years, presented with a first acute symptomatic E. coli urinary tract infection. Investigations included early 99mtechnetium dimercaptosuccinic acid (DMSA) scan (which was performed at a median of 27 days), ultrasonography, micturating cysto-urethrography and indirect voiding radionuclide cystography using 99mTc DTPA. Follow-up DMSA scan was carried out after 6 months. Twenty-one of 102 of initial DMSA studies showed diminished uptake of radionuclide and 12 showed cortical scarring. Twenty-nine patients had significant vesicoureteral reflux (VUR). The finding of diminished uptake on the initial scan was significantly associated with fever, systemic upset, length of symptoms and a peripheral blood leucocytosis, (p less than 0.05). In addition the finding was associated with fever and loin pain in the older child. Both diminished uptake and scarring were more common in refluxing kidney units. We propose that, in children with UTI, diminished uptake on early DMSA scan localises infection in the renal parenchyma.
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PMID:A prospective study of children with first acute symptomatic E. coli urinary tract infection. Early 99mtechnetium dimercaptosuccinic acid scan appearances. 255 21

A group of children (112) at different phase of development, i.e. neonates, infants, preschool and school children were studied for symptomatic UTI. The most common clinical presentations were loin pain (56.4%), fever (50.0%), diarrhea and vomiting (47.4%) in school, preschool and infant groups respectively. In the neonatal group all patients presented with sepsis. In school children fever was more common in those with radiological abnormalities vs those without (p less than 0.005). In neonates intrauterine growth retardation was more common in those with radiological abnormalities (p less than 0.012). Radiological abnormalities were more common in male school children than in female (p less than 0.02). Renal scarring occurred mainly in school children whereas VUR occurred mainly in infants. As male children advance in age there is increased risk of radiological abnormalities. There is an increased percentage of E. coli as causative organism as age increases; from 48.3% in neonates to 74.5% in school children. We conclude that symptomatic UTI is age related in many aspect.
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PMID:Symptomatic urinary tract infection in pediatric patients--a developmental aspect. 391 42

Polycystic kidney disease (PKD) is the most common inherited renal disorder that results in chronic kidney disease. PKD has an autosomal dominant pattern of inheritance. The prevalence is between 1:500 and 1:1,000. Up to 10% of adults with end-stage renal disease (ESRD) have a genetic disorder such as PKD. A family history of PKD may be absent in up to 25% of affected individuals. The most common clinical features are visible haematuria, loin pain, UTI and hypertension. The typical clinical course is a progressive increase in the number and size of renal cysts associated with gradual loss of kidney function (falling eGFR). Risk factors for progression include: younger age at diagnosis; large kidney volume; rapid cyst growth; hypertension; male gender; and visible haematuria. Approximately 50% of individuals with PKD will require renal replacement therapy by the sixth decade of life. PKD is a multisystem disorder associated with multiple bilateral renal cysts, slowly increasing kidney size and progressive chronic kidney disease. Diagnosis of PKD is confirmed by ultrasound showing the presence of multiple kidney cysts. More than 80% will also have multiple liver cysts, which can lead to local pressure effects. Cerebral haemorrhage, secondary to rupture of a berry aneurysm, occurs in up to 8% of individuals. Mitral valve prolapse occurs in up to 25% of patients.
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PMID:Optimising the management of polycystic kidney disease. 2703 21