Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0235394 (wasting)
 8,040 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 30-year-old man had had chronic progressive wasting and weakness of muscles for 17 years. A muscle biopsy 5 years prior to death revealed myopathic changes were rimmed vacuoles and intranuclear inclusions which corresponded to "inclusion body myositis". At autopsy, intranuclear inclusions were observed in neurons, oligodendroglia, and in parenchymal cells of the adrenal medulla. Ultrastructurally, the inclusions in muscles, nervous tissue, and adrenal medulla were identical and consisted of abnormal tubulolinear structures measuring 10-20 nm in diameter. Similar inclusions have been reported in muscles with "inclusion body myositis" and in the nervous system with "neuronal intranuclear hyaline inclusion disease", respectively. Absence of clinical symptoms related to the CNS and adrenal gland, and well-preserved parenchymal cells in these organs of our patient suggest a benign nature of the disease except in the muscular system. Attempts to isolate a virus from the brain were fruitless . This patient may serve to connect both diseases in muscles and the nervous system, and to disclose the etiology of these inclusions.
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PMID:Intranuclear inclusions in muscle, nervous tissue, and adrenal gland. 632 32

Consultants are usually well-meaning people who enjoy the variety of organizations and problems they face in their work. Most do not like to get bogged down in fruitless and wasteful consulting engagement any more than managers of health care organizations like to supervise them, but at least the consultants are paid for their time. The health care organization that defines a project poorly, does not know what it wants from consultants, or does not direct consultants will pay the price in increasingly scarce resources squandered. The tips in the following article for managing an information systems consulting engagement apply to most consulting engagements and to the use of other expensive advisers, such as attorneys and engineers. But information systems is a field particularly foreign, and often threatening, to most administrators and physician executives, so the risk of wasting money on unsuccessful consulting engagements is high.
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PMID:Getting the most benefit from information systems consultants. 1014 Aug 99

Busy diagnosticians need to know what is useful, and what is dross, when dealing with the internet. From the comprehensive array of resources that characterizes the offerings available via the world wide web and email correspondence, in particular, this chapter seeks to identify the most useful tools for the diagnostics laboratory. With rapid communications and fast internet consultations only a few keystrokes away, there really is no point in wasting time on fruitless searches when professionals are so accessible. But accessibility carries the weight of responsibility as well, and communications must be engaged with a fair modicum of civility and common courtesy. Responsibility is a crucially important component of public or semiprivate communication in terms of your own identity, and that of the organization that you represent. Recognition of the relative vulnerability of individual machines to the worldwide disseminated computer viruses, worms, or trojan horses currently abounding, for example, is perhaps the most important step in your approach to security issues, but this recognition must go hand in hand with institutional steps to protect the organization of which you are a part. Organizational tools that serve the diagnostician well in the laboratory can also be mobilized in the aid of communications through the net, and always that harbinger of understanding, common sense, should prevail in one's dealings both with machines, and the people who are communicating either directly or indirectly through them.
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PMID:Molecular diagnostics resources on the Internet. 1495 42