Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0235290 (
bitter taste
)
1,408
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Functional diversification of taste cells is crucial for proper discrimination of taste qualities. We found the
homeodomain protein
Skn-1a (Pou2f3) to be expressed in sweet, umami and
bitter taste
cells. Skn-1a-deficient mice lacked electrophysiological and behavioral responses to sweet, umami and bitter tastes, as a result of a complete absence of sweet, umami and bitter cells and the concomitant expansion of sour cells. Skn-1a is critical for generating and balancing the diverse composition of taste cells.
...
PMID:Skn-1a (Pou2f3) specifies taste receptor cell lineage. 2157 33
