Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0234376 (intention tremor)
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Human Gene/Protein
LEM domain-containing protein 2 16.5
lysosomal acid beta-galactosidase 13.0
SCA12 12.7
VAC14 12.0
FMR1 protein 11.8
COX15 11.7
CUL4B 11.5
POLR3A 10.8
PPP2R2B 10.7
SCA5 10.7
FMR1 10.5
FIG4 10.4
MDB 10.4
FMRP 10.3
beta-mannosidase 10.3
SMPD1 10.0
KIF5A 9.9
spinocerebellar ataxia type 2 9.3
RAN 9.2
sterol carrier protein-2 9.1
nuclear envelope protein 9.1
P37 9.1
MERRF 8.8
fragile X mental retardation protein 8.8
sterol 27-hydroxylase 8.8
PIKfyve 8.7
CV2 8.7
SCA3 8.7
MBP mRNA 8.7
GSS 8.6
hnRNP A2 8.6
GAN 8.4
mGlu1 8.3
Sam68 8.2
FIM 8.2
Cav2.1 8.0
amphiphysin 7.9
CACNA1A 7.9
DBS 7.7
steroid sulfatase 7.7
PMP22 7.6
jerky 7.6
2-oxoglutarate dehydrogenase 7.5
Smith-Lemli-Opitz syndrome 7.4
dach 7.3
microsomal triglyceride transfer protein 7.2
pleiotrophin 7.0
ATP7B 6.9
MR-1 6.8
lamin A/C 6.8
ferroxidase 6.7
Hsp40 6.6
CD79a 6.4
Iba1 6.4
SEP 6.3
AR protein 6.3
acid sphingomyelinase 6.2
myelin-associated glycoprotein 6.2
neurofilament protein 6.1
Wilson disease 6.1
frataxin 6.1
DAT 6.0
gamma2 5.9
pyruvate dehydrogenase complex 5.7
MIM 5.7
ADHD 5.6
IL2 5.5
HSP 5.5
ceruloplasmin 5.5
metabotropic glutamate receptor 5.4
phosphatase and tensin homolog 5.4
5-HT3 receptor 5.3
troponin I 5.3
MRI 5.1
sit 5.0
N-acetylaspartate 4.9
ubiquitin 4.8
beta-tubulin 4.8
myelin basic protein 4.6
strabismus 4.5
more...
Disease
X-Linked Mental Retardation 14.9
beta-Mannosidosis 14.2
XXYY syndrome 13.0
SCA12 12.7
Opsoclonus myoclonus 12.0
FXTAS 12.0
Neuroaxonal dystrophy 11.9
HPNS 11.3
SCA5 11.3
Optic disc drusen 11.2
Essential tremor 11.1
Speech impairment 11.1
Lack of insight 11.0
Paraneoplastic cerebellar degeneration 11.0
nervous disorder 10.6
Niemann-Pick disease type A 10.5
cerebellar syndrome 10.4
Cerebellar atrophy 10.4
XYY syndrome 10.3
Opsoclonus 10.2
basal ganglia disease 10.2
cardiofaciocutaneous syndrome 10.1
PDH deficiency 10.0
mannosidosis 9.9
eye movement disorder 9.7
choreoathetosis 9.3
Familial hemiplegic migraine 9.3
Minamata disease 9.2
Central pontine myelinolysis 9.2
Upper limb 9.2
radioulnar synostosis 9.1
FHM 9.0
MERRF 8.8
minimal brain dysfunction 8.7
Crigler-Najjar syndrome 8.6
fragile X syndrome 8.4
embryonal tumor 8.3
emotional disorder 8.3
Cerebellum 8.3
GM1 gangliosidosis 8.3
nystagmus 8.2
FIM 8.2
Copper deficiency 8.1
myoclonus epilepsy 8.0
brain atrophy 7.9
movement disorder 7.9
Spinocerebellar ataxia 7.9
speech disorder 7.8
generalized disease 7.7
Machado-Joseph disease 7.7
torsion dystonia 7.6
spastic paraplegia 7.6
Wilson's disease 7.5
Joubert syndrome 7.5
delayed puberty 7.5
cognitive disorder 7.5
visual dysfunction 7.4
macrocephaly 7.4
hemiplegic migraine 7.3
HFA 7.3
spastic diplegia 7.2
Smith-Lemli-Opitz syndrome 7.2
Cowden syndrome 7.2
parkinsonism 7.2
anaplastic astrocytoma 7.2
thyroid disorder 7.2
abnormal involuntary movements 7.1
moderate mental retardation 7.1
kernicterus 7.1
Dystonia 7.0
dyskeratosis congenita 7.0
exotropia 7.0
Leigh syndrome 6.9
akinesia 6.9
paraneoplastic syndrome 6.8
Dandy-Walker malformation 6.8
DVT 6.8
attention deficit disorder 6.7
peripheral neuropathy 6.7
night blindness 6.6
more...
Symptom
intention tremor 16.5
Dysdiadochokinesis 14.2
Postural tremor 12.9
Rest tremor 12.3
Primary orthostatic tremor 12.2
abiotrophy 12.1
Parkinsonian tremor 11.6
ataxic gait 11.5
Ataxic 10.3
tremor 9.8
ataxia 9.4
cerebellar ataxia 9.4
clumsiness 9.4
dysarthria 9.3
clonus 9.0
asterixis 8.8
myoclonus 8.5
athetosis 8.4
Physical findings 8.1
abnormal gait 7.9
consciousness disturbance 7.8
loss of balance 7.7
muscle cramps 7.7
incoordination 7.3
dystonia 7.2
neck stiffness 7.2
spasticity 7.1
hypotonia 7.1
chorea 7.0
torticollis 6.8
ophthalmoplegia 6.8
memory loss 6.7
blepharospasm 6.5
eds 6.4
muscle rigidity 6.4
decreased appetite 6.3
bradykinesia 6.3
hypertonia 6.2
hemiplegia 6.1
sore throat 6.0
dizziness 5.8
weakness 5.4
hepatosplenomegaly 5.4
dysuria 5.2
paresthesia 5.2
pallor 5.2
tachypnea 5.2
paraparesis 5.0
paresis 5.0
vertigo 4.7
thinning 4.6
neck pain 4.5
agitation 4.5
apathy 4.5
nausea 4.3
headache 4.2
numbness 4.1
shortness of breath 4.1
vomiting 4.1
lethargy 4.0
seizures 3.9
sleepiness 3.8
myalgia 3.8
tinnitus 3.8
anorexia 3.7
arthralgia 3.7
fatigue 3.6
spasm 3.6
insomnia 3.1
cough 2.9
erythema 2.8
hypothermia 2.4
pain 0.8
diarrhea 0.7
anesthesia -0.3
Drug
Glutethimide 11.3
Nadolol 9.1
Pregabalin 7.7
DBS 7.7
Singular 7.5
Vitamin B12 7.2
Ranitidine 6.8
Spectrum 4.5
CSF 4.1
Spectrum 3.5
vitamin E 2.4
Leaf 2.1
lysine 0.6
Enzyme
bilirubin oxidase 8.5
mannanase 8.2
CYP27A1 7.4
arylsulfatase 6.2
alpha-ketoglutarate dehydrogenase 6.2
DAT 6.0
ceruloplasmin 5.2
protein phosphatase 2A 4.9
hexosaminidase 4.7
kinesin 4.2
pyruvate dehydrogenase 4.0
creatine kinase 3.3
beta-galactosidase 2.6
tyrosine hydroxylase 2.6
calcineurin 2.4
proteasome 1.7
luciferase 1.3
catalase 0.7
Compound
Glutethimide 11.7
Harmaline 9.4
Botulinum toxin type A 8.5
Clonazepam 7.7
DBS 7.7
Flumazenil 7.5
NFS 7.5
2,5-hexanedione 7.0
Lamotrigine 6.9
Metoprolol 6.9
Metoprolol 6.8
Vincristine 6.6
T 1 6.5
norleucine 6.4
Histidine 6.0
DAT 6.0
UDP-galactose 5.9
DPA 5.9
DPA 5.9
DPA 5.9
DPA 5.9
DPA 5.9
Amiodarone 5.8
GM2 5.7
Propranolol 5.5
PPI 5.4
Propranolol 5.4
Retard 5.4
GM3 5.4
A 71 5.4
Capsaicin 5.1
ACM 4.9
5-hydroxytryptophan 4.8
N-acetylaspartate 4.8
Serine 4.8
Neuronal 4.6
hydroxyindoleacetic acid 4.5
EMS 4.4
MPTP 4.1
Cortisol 4.0
GM1 3.9
PAS 3.9
GlcNAc 3.8
Isoproterenol 3.7
2-oxoglutarate 3.6
CAT 3.3
CAT 3.3
Collagen 3.3
L-DOPA 3.3
mercury 3.3
toluene 3.3
CAT 3.2
His 3.2
oxalate 3.2
tin 2.9
MEK 2.8
Thyroid 2.6
gamma-aminobutyric acid 2.5
formaldehyde 2.5
acrylamide 2.4
GABA 2.4
GABA 2.4
formaldehyde 2.2
aluminum 1.7
creatinine 1.6
carbonate 1.6
copper 1.6
5-HT 1.5
manganese 1.4
glutamate 1.3
tryptophan 1.1
ADP 1.1
bromide 1.1
methanol 0.6
serine 0.5
alanine 0.4
galactose 0.3
Dec 0.2
lysine 0.1
DNA 0.1
more...