Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0234233 (Tenderness)
 375 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Four hundred ninety eight children of 15 months to 5 years of age were immunized with 0.5 ml of b-CAPSATM I Haemophilus influenzae type b polysaccharide vaccine (Hib). Every other child received the vaccine subcutaneously (S.C.) and the alternates received the vaccine intramuscularly (I.M.). Two hundred and two (81.1%) children in the S.C. group and 198 (79.5%) children in the I.M. group returned for follow-up visits 48-72 hours after the immunization and had the adverse reactions documented. The rest were contacted by telephone. After matching for sex and age, we had 194 pairs (103 males and 91 females) in each group with a mean age difference between the pairs of 0.4 month. Based on paired comparisons, pain, manifested as crying, at the time of inoculation was more frequent with intramuscular administration (p less than 0.01). Tenderness at the injection site occurred in 4 children in the I.M. group but none in the S.C. group and was of borderline statistical significance (p = 0.06). The occurrence of other adverse reactions was not significantly different between the two groups. The findings of this study suggest that subcutaneous injection is the method of choice for Hib vaccine administration.
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PMID:Subcutaneous versus intramuscular administration of Haemophilus influenzae type b vaccine. 250 May 25

The reliability and validity of an algometer pressure threshold meter (PTM) was evaluated on 45 individuals, 25 healthy volunteers and 20 patients with craniomandibular dysfunction. Tenderness upon palpation was measured at six points located on the masseter muscle, the anterior temporal muscle, and on the zygomatic arch. The validity of the PTM was evaluated by comparison of the PTM values obtained by one examiner with the finger palpation score obtained by another examiner (Part 1). A statistically significant correlation between PTM values and finger-palpation scores was found at all of the points recorded (p less than 0.05). A statistically significant difference between PTM values was obtained for the symptom-free group and the patient group. The reliability of the PTM was evaluated at six points by repeated recordings at each marked point (Part 2). High reliability coefficients (r = 0.79-0.94) were found at all the points. The study also showed that if the points were located with a certain inaccuracy (1.0 mm less than x less than 2.6 mm), the reliability coefficients were still of the same magnitude. The PTM can be recommended for evaluation of pressure pain thresholds in the masticatory system in clinical and experimental studies.
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PMID:Reliability and validity of a pressure threshold meter in recording tenderness in the masseter muscle and the anterior temporalis muscle. 263 11

A case of primary torsion of the omentum is reported. A 37-year-old male was admitted with the chief complaint of RLQ pain of 3 day's duration on June 10, 1986. Tenderness and Blumberg's sign were found at Mc Burney's point with leucocytosis of 11,500/mm3. His body temperature was not elevated. Operation was carried out under the diagnosis of suspicion of acute appendicitis. Laparotomy revealed a dark-red omental mass of 12 X 5 X 1 cm which had been formed by torsion (7 times, clock-wise) and a little clear ascites. The omental mass was resected, and appendectomy was also performed. The postoperative course was uneventful. Eighteen cases including this case in the Japanese literature were reviewed and reported.
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PMID:[Primary torsion of the omentum--report of a case and review of the Japanese literature]. 268 99

Tenderness in the anatomical snuff box (ASB) has long been accepted as an indicator of a possible scaphoid fracture. The longitudinal axis of the scaphoid lies in an anteroposterior plane, perpendicular to the remainder of the carpal bones, in the radially deviated wrist. The scaphoid tubercle can therefore be easily and accurately palpated on the palmar aspect of the radially deviated wrist. This study was devised to determine if tenderness over the scaphoid tubercle (ST) was superior to ASB tenderness in identifying definite fractures. Over a 10-month period 246 patients were seen who were suspected of having a scaphoid injury. Thirty (12%) were eventually proven to have definite fracture. Tenderness in the ASB had a sensitivity rate of 90% (95% confidence limits 80-100%) and specificity of 40% (33-47%) as an indicator of a definite fracture. ST tenderness had a sensitivity of 87% (75-99%) and specificity of 57% (50-64%). There is therefore no significant difference in the sensitivity between ASB and ST tenderness but ST tenderness is significantly more specific. However, the presence of either ASB or ST tenderness should be used in order to identify all fractures. Patients with neither ASB nor ST tenderness require symptomatic treatment only.
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PMID:Scaphoid tubercle tenderness: a better indicator of scaphoid fractures? 271 88

Electromyograms (EMGs) of the temporal and masseter muscles in sixty patients with temporomandibular joint disturbance syndrome (TMJDS) and thirty controls were recorded and integrated on-line in the postural position and during maximum clenching, before and after occlusal splint therapy. Contrasting with the controls, the myoelectrical activity of the patients was higher in the postural position and lower during maximum clenching, whilst the former in percentage terms increased when compared to the latter. After treatment, the EMG indexes in some patients returned partially, and in others completely, to a normal level. Tenderness in the mandibular elevators, deviated opening and organic change in the TMJ increased the postural myoelectrical activity, in percentage terms, against that of maximum clenching. The myoelectrical activity of the mandibular elevators in the postural position and during maximum clenching was smaller in patients with the occlusal splint than in those without. The results show that the mandibular elevators in the patients with TMJDS were hyperactive and tense, and that the occlusal splint was useful for treating such dysfunction.
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PMID:Postural and maximum activity in elevators during mandible pre- and post-occlusal splint treatment of temporomandibular joint disturbance syndrome. 271 63

A 49-year-old woman complained of 3 months of constant aching pain deep to the ingrown medial nail margin of her right hallux that was unaffected by shoe wear. Physical examination disclosed no purulence, discoloration, or obvious acute inflammation; an incurved medial nail plate was seen. There was mild chronic thickening of the medial nail fold. Tenderness was maximal 2 to 3 mm plantar to the medial edge of the nail. By roentgenogram, bony projections were seen arcing from the distal phalangeal tuft and the proximal metaphyseal flare toward each other. This was considered to be a "normal" radiological variant. A partial medial onychectomy and matricectomy (Winograd procedure) was performed. Further dissection 1 to 2 mm deeper along the medial phalangeal border revealed a 1-mm wide longitudinal ligament extending from the phalangeal distal tuft to the proximal metaphyseal flare. Bony projections and ligament were excised. The wound healed satisfactorily, and symptoms ceased.
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PMID:Lateral supporting ligament of the distal phalanx. 274 74

We have investigated the use of dolorimetry in the assessment of algodystrophy of the hand. Findings in 12 affected patients following Colles' fracture were compared with age- and sex-matched normal controls. Algodystrophy was associated with a significant increase in tenderness of both the finger joints and bones. Tenderness of the whole hand was quantified by summing the dolorimetry readings at each site within the hand and the ratio of the summed readings for the two hands was defined as the dolorimetry ratio. This ratio was highly reproducible and independent of external variables. It was significantly lower in patients with algodystrophy than in controls and may provide a method for the diagnosis and serial assessment of the disorder.
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PMID:The use of dolorimetry in the assessment of post-traumatic algodystrophy of the hand. 279 Apr

In the past, treatment of oral lichen planus (OLP) was usually discontinued by patients due to the many adverse effects such as drug-induced side effects, scarring, etc. In this study, 35 patients with severe OLP which was verified histologically were subjected to irradiation. The lesions were irradiated with ultraviolet (UV) light at wave lengths of 320-400 nm for 5-10 minutes per single exposure once a week. During each irradiation, the patients were protected with eye goggles and no photosensitizer was added. Soreness and discomfort of the oral lesions were markedly relieved after irradiation for 4 treatments. By comparing the pre- and post-treatment findings from clinical, histological and immunohistochemical examinations, 30(85.7%) out of the 35 patients were either cured or improved after 8 treatments of UV-A irradiation. The advantages of UV-A irradiation therapy are as follows: (1) fewer erythemic-induced side effects: (2) marked improvement of lesions within a short period; and (3) no malignant transformation during a period of 5 years following the irradiation.
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PMID:A newly developed method for treatment of oral lichen planus with ultraviolet irradiation. 279 23

To establish inter-rater and test-retest reliability of use of a pressure algometer, 5 males and 5 females suffering from chronic fibromyalgia ('fibrositis'), and a normal group of 5 males and 5 females, were examined 2 times by each of 2 independent examiners, using 1 kg/sec rate of application, over 10 paired and typical 'tender points,' localized by skin marker. Tenderness thresholds of tender points were coded and analyzed using repeated measures ANOVA, for factors sex, normal/fibromyalgia, and side, rater, and time 1/time 2. There was significantly lower tenderness thresholds of tender points in fibromyalgia compared to normal subjects. Generalizability coefficients were calculated and showed high inter-rater (0.85), and test-retest (0.85) reliability. Highly significant differences were found between specific tender points. A further 10 normals and 10 fibromyalgia subjects were then examined for 5 paired tender points and 5 paired non-tender points. A 2-way ANOVA was conducted for summed and averaged scores for all tender and non-tender points, with factors normal/fibromyalgia and tender/non-tender; again, there was a large difference between normal and fibromyalgia subjects, and between tender and non-tender points. The interaction was small but significant, but there was a larger difference between fibromyalgia and normal subjects observed on non-tender points. The low tenderness threshold observed at the tender points of fibromyalgia patients may reflect a more generalized lowering of tenderness thresholds, seen at non-tender points as well.
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PMID:Tender points in fibromyalgia. 316 24

During the past 6 years, ten children with reflex sympathetic dystrophy were treated. Pain in an extremity was the initial complaint in all patients. The pain was unilateral in 90% of the patients; upper and lower extremities were affected with equal frequency. Tenderness to palpation, extreme hyperesthesia, and dysesthesia were other dominant features. All patients had some evidence of autonomic nervous system dysfunction in the affected extremity (swelling, color change, decreased temperature, and/or hyperhidrosis). The median duration of symptoms prior to referral and diagnosis was 5 months. All children were treated as outpatients with a transcutaneous electric nerve stimulator and home-based physical therapy. With this regimen, seven patients had complete remission within 2 months. Two other patients improved with transcutaneous electric nerve stimulation therapy, and one patient had no response to transcutaneous electric nerve stimulation. Reflex sympathetic dystrophy is frequently underdiagnosed in children. Increased awareness of this syndrome is important because accurate diagnosis is crucial and transcutaneous electric nerve stimulation offers a safe, simple, and effective outpatient therapy for reflex sympathetic dystrophy in children.
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PMID:Reflex sympathetic dystrophy in children: treatment with transcutaneous electric nerve stimulation. 326 17


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