Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0234233 (Tenderness)
 375 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study investigated the natural history and treatment of cutaneous abscesses in an outpatient setting. Incision, drainage, aerobic and anaerobic cultures were done on all 78 patients entered in the study. Tenderness and fluctuance were noted in more than 80% of the patients; erythema and induration in more than 60%. Forty-one percent of all abscesses were in the anogenital region. Forty-two percent of cultured abscesses grew aerobes exclusively, 28% grew anaerobes exclusively, and 27% grew a mixture of aerobes and anaerobes. The predominant aerobic organisms were Staphylococcus and Streptococcus, which were mostly isolated from the head/neck, extremities, and axillary regions. The predominant anaerobic organisms were Peptococcus and Bacteroides, which were primarily isolated from the anogenital regions. Nearly 60% of the patients returned for reevaluation. They were equally divided between those patients taking antibiotics and those not on antibiotics. However, all patients were clinically improved.
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PMID:Cutaneous abscesses: natural history and management in an outpatient facility. 644 42

The clinical features of long bone infarction in patients with sickle cell disease have not been well defined, and differentiation of bone infarct from osteomyelitis has accordingly been difficult. We reviewed records from 192 children with sickle hemoglobinopathies and identified 41 episodes of acute long bone infarction in 21 patients. The most commonly affected bones were the humerus (38%), tibia (23%), and femur (19%). The distal segment was more commonly involved. Tenderness and prominent swelling occurred in all cases; other findings included impaired joint motion (68%), local heat (65%), and erythema (145). Fever was usually absent or low grade, and patients did not appear ill. Laboratory studies included negative bacterial cultures in all cases, absence of left shift in WBC count in most, and variable erythrocyte sedimentation rate. Plain roentgenographs were unremarkable. Contrary to previous reports, radionuclide bone and bone marrow scans were not helpful in differentiation of bone infarction from osteomyelitis. Patients received supportive therapy and improved within several days. Long-term sequelae were not evident. The rarity of osteomyelitis in our sickle cell population (five cases in 22 years) precluded direct comparison of most of its clinical features with those of bone infarction. Acute long bone infarction is at least 50 times more common than bacterial osteomyelitis in sickle cell disease.
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PMID:Acute infarction of long bones in children with sickle cell anemia. 709 7

Acute otitis externa is a common condition involving inflammation of the ear canal. The acute form is caused primarily by bacterial infection, with Pseudomonas aeruginosa and Staphylococcus aureus the most common pathogens. Acute otitis externa presents with the rapid onset of ear canal inflammation, resulting in otalgia, itching, canal edema, canal erythema, and otorrhea, and often occurs following swimming or minor trauma from inappropriate cleaning. Tenderness with movement of the tragus or pinna is a classic finding. Topical antimicrobials or antibiotics such as acetic acid, aminoglycosides, polymyxin B, and quinolones are the treatment of choice in uncomplicated cases. These agents come in preparations with or without topical corticosteroids; the addition of corticosteroids may help resolve symptoms more quickly. However, there is no good evidence that any one antimicrobial or antibiotic preparation is clinically superior to another. The choice of treatment is based on a number of factors, including tympanic membrane status, adverse effect profiles, adherence issues, and cost. Neomycin/polymyxin B/hydrocortisone preparations are a reasonable first-line therapy when the tympanic membrane is intact. Oral antibiotics are reserved for cases in which the infection has spread beyond the ear canal or in patients at risk of a rapidly progressing infection. Chronic otitis externa is often caused by allergies or underlying inflammatory dermatologic conditions, and is treated by addressing the underlying causes.
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PMID:Acute otitis externa: an update. 2319 73