Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0234215 (discomfort)
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Human Gene/Protein
transient receptor potential cation channel, subfamily M, member 8 8.8
VMAC 8.0
Prolactin-induced protein 7.5
HSCB 7.3
envelope polyprotein 7.2
FRMD5 7.2
MMP23B 7.2
cornifelin 6.9
PATE 6.8
AdPLA 6.6
GLRA3 6.6
NAP5 6.5
V2-6 6.4
PLA2G16 6.3
CLAN 6.3
VIPL 6.3
BRAP2 6.3
D4DR 6.3
mucosal vascular addressin cell adhesion molecule 1 6.2
STL3 6.1
V1-4 6.0
BAP-1 6.0
NIBP 5.9
histamine receptor H1 5.8
angiopoietin-3 5.8
SPAP 5.6
BGR 5.6
OAF 5.6
EMP2 5.5
XYLT2 5.5
GLC3A 5.4
Wah 5.4
HMIC 5.3
TDAG8 5.3
K10 5.3
V4-6 5.3
PIPP 5.3
BTBD9 5.3
CCBE1 5.3
Interleukin 17A 5.2
PDYN 5.2
SYR 5.2
CYP4F22 5.2
SOLO 5.1
HS6ST1 5.1
ST8SIA4 5.0
XT2 5.0
desmosomal glycoprotein 1 5.0
CCKBR 5.0
GL183 5.0
NIP1 4.9
CNTN3 4.9
Dermatopontin 4.9
mitochondrial aldehyde dehydrogenase 2 4.9
CLIP2 4.9
PG-Lb 4.9
CMPD 4.9
FLIR 4.8
ZFHX1B 4.8
MISS 4.8
TBX4 4.7
UBF1 4.7
CEAP 4.7
KMO 4.7
ILF 4.6
SEMG 4.6
LSM1 4.6
SCL 4.6
tec 4.5
IMP2 4.5
UST 4.5
FAG 4.5
ZAR1 4.5
FACT 4.5
MFT 4.5
NBAS 4.5
VDP 4.5
MUC5AC protein 4.4
fibrinogen alpha chain 4.4
LARS 4.3
more...
Disease
Trophic leg ulcer 10.3
Sleep Bruxism 10.3
Idiopathic vulvodynia 10.3
Venous lake 10.3
melanemia 10.3
metastatic gastrointestinal carcinoid tumor 10.3
Dental discomfort 10.3
Acquired Deafness 10.3
Extraskeletal Ewing's sarcomas 10.3
Infestation by land leeches 10.3
Premenstrual pain 10.3
Bronchial polyps 10.3
Other esophageal disorders 10.3
SPPK1 10.3
Self-incineration 10.3
Vestibular papillomatosis 9.3
Synchysis scintillans 9.3
Rectovesical fistula 9.3
Carcinomatous pleurisy 9.3
Chronic eczema 9.3
Diabetic gastropathy 9.3
Spinal claudication 9.3
Vulval edema 9.3
Uncomplicated diverticular disease 9.3
infective sinusitis 9.3
Follicular conjunctivitis 9.3
Butting 9.3
emotional distress 8.8
Non-bacterial prostatitis 8.8
Granular myringitis 8.8
Herpetic stomatitis 8.8
Acute iritis 8.8
Corlett 8.6
Syphilitic aortic aneurysm 8.3
Tuberculous epididymo-orchitis 8.3
Chronic post-thoracotomy pain 8.3
Axillary vein thrombosis 8.3
Macrodactylia 8.3
eustachian salpingitis 8.3
Psychogenic vomiting 8.3
recurrent malignant mesothelioma 8.3
Acute gangrenous cholecystitis 8.3
Pearly penile papules 8.3
Epithelioid leiomyosarcoma 8.3
Splenic cyst 8.3
Ocular discomfort 8.2
Gangliocytoma 8.0
Staphylococcus aureus mediastinitis 8.0
relationship disorder 8.0
Bicipital tendinitis 8.0
Generalized hyperhidrosis 8.0
Purulent peritonitis 8.0
Aqueous tear deficiency 8.0
Superior limbic keratoconjunctivitis 8.0
Involutional entropion 8.0
Acute dermatitis 8.0
Anterior epistaxis 8.0
stage III renal cell carcinoma 8.0
Postoperative chest infection 8.0
psychological disability 7.9
Tooth surface loss 7.9
Situational anxiety 7.8
Conjunctivochalasis 7.8
Thyrotoxicosis factitia 7.8
Aquagenic pruritus 7.8
Gastrointestinal fistula 7.8
Loin pain hematuria syndrome 7.8
Pelvic hemorrhage 7.8
Postoperative urinary tract infection 7.8
Mauclaire 7.8
cancer seeding 7.8
Functional dyspepsia 7.6
Eosinophilic gastritis 7.5
Psychogenic cough 7.5
Xanthine oxidase deficiency 7.5
Pyogenic hepatic abscess 7.5
Psychophysiological insomnia 7.5
Clitoris 7.5
Perianal Paget's disease 7.4
Irrationality 7.3
more...
Symptom
Back discomfort 10.3
Lumbar syndrome 10.3
Rough mouth 10.3
Eyelid margin hyperemia 10.3
discomfort 10.3
Shoulder discomfort 10.3
Thyroid pain 10.3
Leg discomfort 10.3
Idiopathic scrotal edema 10.3
discomfort 10.3
bad taste in mouth 10.3
Arm discomfort 10.3
Foot discomfort 10.3
Visual discomfort 10.2
Musculoskeletal discomfort 9.9
Neck discomfort 9.3
Postoperative dizziness 9.3
Nasal discomfort 9.3
Postoperative constipation 9.3
redness of the nose 9.3
Sensation of warmth 9.3
symptoms; development 9.3
Epigastric discomfort 9.3
Breast discomfort 9.0
General discomfort 8.8
Pruritus of pregnancy 8.8
trigonal irritation 8.8
Intercostal neuralgia 8.8
GI pain 8.7
prostatic tenderness 8.5
change in bowel movements 8.5
Vulval pain 8.3
Anorectal pain 8.3
Phonophobia 8.2
glossopyrosis 8.0
feeling of choking 8.0
Oral discomfort 8.0
Auspitz's sign 8.0
Chest discomfort 7.9
Early satiety 7.9
Vocal fatigue 7.8
Gastrointestinal discomfort 7.8
ovulatory bleeding 7.8
Lid lag 7.8
Oral Manifestations 7.8
Cognitive Symptoms 7.5
Rebound tenderness 7.5
feeling of malaise 7.5
respiratory pain 7.5
Multiple symptoms 7.5
sacralgia 7.5
vulval irritation 7.5
Scintillating scotoma 7.5
Mild pain 7.5
Rectal sensation 7.4
skin pain 7.4
change in stool 7.4
Transient neurological symptoms 7.3
Premenstrual symptoms 7.3
feeling dizzy 7.3
Other pain 7.2
Throat symptoms 7.2
Dyspnea at rest 7.2
Refractory angina pectoris 7.0
Penile pain 7.0
swollen penis 7.0
Incisional pain 7.0
Chills and fever 7.0
sinus pain 7.0
Purulent discharge 7.0
Perineal pain 7.0
Withdrawal Symptom 7.0
bloating 6.9
throat irritation 6.9
vaginal discomfort 6.9
skin impairment 6.9
Vulvodynia 6.9
Cutaneous allodynia 6.8
Harshness 6.8
Homan's sign 6.8
more...
Drug
Ricinoleic Acid 10.3
Tecadenoson 9.3
Alfenta 9.3
Bucladesine sodium 9.3
Scopolia extract 8.8
Histrelin acetate 8.8
Deracoxib 8.3
Methadyl acetate 8.3
Alosetron 8.1
Meteneprost 8.0
Privine 8.0
Hexabrix 320 8.0
Lacrisert 7.8
Cerebyx 7.5
IHMS 7.5
Protonix 7.5
Emla 7.4
Emla 7.4
Calcium polycarbophil 7.3
Podofilox 7.3
Percocet 7.3
Iopentol 7.3
Tegaserod 7.2
Darvon 7.1
Azopt 7.0
Ultiva 7.0
Cilansetron 7.0
Blenoxane 7.0
Mosapride citrate 7.0
Thyrogen 6.9
Versed 6.9
Tegaserod 6.9
Emla 6.9
Pro-Banthine 6.9
Patanol 6.9
Ecabet sodium 6.9
Myfortic 6.9
Pantoprazole sodium 6.8
Torecan 6.8
Torecan 6.8
Propine 6.8
Medicon 6.7
Iodixanol 6.7
Quinine sulfate 6.6
Sarpogrelate hydrochloride 6.6
Citanest 6.6
Citanest 6.6
Selenium sulfide 6.5
Apomorphine hydrochloride 6.5
Tantum 6.5
Amethocaine 6.5
Iotrolan 6.5
Roquinimex 6.4
Concor 6.4
Octapressin 6.4
Meridia 6.3
Ganda 6.3
C2H5Cl 6.3
Azelastine hydrochloride 6.3
Pranoprofen 6.3
Meridia 6.3
Medicon 6.3
Citrus unshiu peel 6.3
Calamine 6.3
Elmiron 6.3
Omniscan 6.2
Isopaque 6.2
Mizolastine 6.2
Tafluprost 6.2
Dioctyl sodium sulfosuccinate 6.2
Avanafil 6.2
Conray 6.2
Methyl aminolevulinate 6.1
Novafil 6.1
Cetrotide 6.1
Buscopan 6.1
Pentosan polysulfate sodium 6.0
Cefbuperazone 6.0
Myo-Inositol 6.0
Mircette 6.0
more...
Enzyme
PATE 6.5
MSAS 6.5
NAAT 4.9
RGP 4.5
CTS2 3.5
alliinase 3.4
SOR 3.4
homoserine kinase 3.3
PWD 3.3
SRR 3.3
IOR 3.1
inosine triphosphatase 3.1
NMT 3.0
phosphoribulokinase 2.9
MCS 2.7
HDR 2.7
chymopapain 2.7
DAT 2.6
chymopapain 2.6
TDH 2.6
ancrod 2.5
BIS 2.4
PPH 2.4
HVS 2.4
CFI 2.3
lactase 2.3
CAD 2.2
CAD 2.2
estrogen sulfotransferase 2.2
CAD 2.2
hyaluronidase 2.2
EPT 2.1
CCS 2.1
VOR 2.0
SCS 2.0
alpha-galactosidase 1.9
PNL 1.9
FPS 1.9
AOR 1.9
SOR 1.9
PRE 1.8
rhodopsin kinase 1.8
cathepsin C 1.7
hyaluronidase 1.7
PMT 1.7
creatine kinase 1.6
DMT 1.4
prostate-specific antigen 1.3
SPT 1.3
thiopurine methyltransferase 1.2
meprin 1.2
PTA 1.2
CDH 1.2
tryptophan hydroxylase 1.1
botulinum neurotoxin 1.0
BMT 1.0
CPM 1.0
tryptase 0.9
glycerol kinase 0.8
TACE 0.7
BAT 0.6
PST 0.6
AST 0.6
FFT 0.6
aldehyde dehydrogenase 0.6
aldehyde dehydrogenase 0.6
diacylglycerol acyltransferase 0.6
aldehyde dehydrogenase 0.6
MDP 0.5
SPT 0.5
BMA 0.5
prostaglandin synthetase 0.5
aldehyde dehydrogenase 0.5
carbonic anhydrase 0.5
urease 0.5
interstitial collagenase 0.5
gamma-glutamyl transpeptidase 0.4
bromelain 0.3
aldehyde dehydrogenase 0.3
thymidine phosphorylase 0.3
more...
Compound
Papyriferic acid 10.3
Pramoxine 10.3
Papyriferic acid 9.3
S 31 8.8
Lincomycin hydrochloride 8.8
9,10-Anthracenedicarboxaldehyde 8.3
Brinzolamide 8.2
Visnadine 7.8
Alverine citrate 7.8
Gadodiamide 7.3
11(R)-HETE 7.3
Moxisylyte hydrochloride 7.3
Mebeverine hydrochloride 7.2
Deaner 7.0
Trazodone hydrochloride 6.8
Torecan 6.8
Doxepin hydrochloride 6.6
2,4-Di-tert-butylphenol 6.6
2,4-DCA 6.5
Ketaset 6.5
CPDS 6.5
2ip 6.5
2,4-Di-tert-butylphenol 6.5
Cyclobenzaprine 6.4
Dipivefrin 6.4
I-123 BMIPP 6.4
Isopaque 6.3
Apomorphine hydrochloride 6.3
lauramide 6.3
Metaxalone 6.3
L-Proline, 6.2
Metipranolol 6.2
PDQ 6.1
Cytembena 6.1
Acotiamide 6.1
Eflornithine 6.1
ST-37 6.1
Levobunolol 5.8
Dicyclomine 5.8
Fosphenytoin 5.7
MHT 5.7
Pivampicillin 5.6
Rhizoxin 5.5
Josamycin 5.5
Josamycin 5.5
Josamycin 5.4
4-methylquinazoline 5.4
Prilocaine 5.4
Betnesol 5.3
Relax 5.3
SMP2 5.3
Sucralfate 5.3
1-methoxy-2-propanol 5.3
EPB 5.2
octyl acetate 5.2
Ditan 5.2
Bixin 5.1
Bixin 5.1
2-methylpropanamide 5.1
Azaperone 5.1
Tolterodine 5.0
Mafosfamide 5.0
Methylxanthine 5.0
Cisapride 5.0
A 99 4.9
3-O-methyldopamine 4.9
Clemastine 4.9
Rocuronium 4.9
Dorzolamide 4.9
Prochlorperazine 4.8
Mephenytoin 4.8
Etidocaine 4.8
Pantethine 4.8
tropic acid 4.8
MTN 4.7
Quine 4.7
Etoricoxib 4.7
Methazolamide 4.7
PBZ 4.7
Oxymetazoline 4.7
more...