Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0233794 (memory impairment)
 7,237 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
CA1 438
Sep 434
acetylcholinesterase 320
brain-derived neurotrophic factor 269
Mol 260
amyloid precursor protein 249
MRI 216
superoxide dismutase 187
TNF 167
GSH 157
CA3 155
caspase-3 144
catalase 126
lipopolysaccharide 126
NMDA receptor 125
Mem 120
APP 119
insulin 117
amyloid beta 108
glutathione peroxidase 103
glial fibrillary acidic protein 98
GABA 96
CREB 87
cytokine 84
tumor necrosis factor 84
choline acetyltransferase 83
olfactory 83
PS1 82
Bcl-2 82
tau protein 76
IL-6 75
synaptophysin 68
inducible nitric oxide synthase 59
axonal 53
GSK 49
BACE1 49
AChE 48
histone 47
muscarinic receptor 47
PSD-95 45
SOD 45
ROS 45
She 42
ATP 42
ERK 42
apolipoprotein E 40
CB1 39
glutamate receptor 38
neurotrophic factor 38
rat) 37
ERK1 37
DCX 36
cAMP response element-binding protein 35
mTOR 32
AKT 32
IL-10 32
NR2B 32
presenilin 1 31
MAPK 31
WMS 30
nerve growth factor 30
PKA 30
extracellular signal-regulated kinase 30
p65 30
Nrf2 30
LPS 29
CaMKII 29
nitric oxide synthase 29
mouse) 29
TLR4 29
gut 28
PI3K 28
neurotrophin 28
calmodulin 28
phosphodiesterase 28
COX-2 27
histone deacetylase 27
interleukin-6 27
nicotinic acetylcholine receptor 27
ATPase 27
esterase 26
FDG 26
p38 25
cage 25
butyrylcholinesterase 25
STZ 25
cytochrome c 24
JNK 24
APOE 23
opioid receptor 23
AMP 23
endoplasmic reticulum 23
calcineurin 23
protein kinase B 23
HO-1 23
synuclein 22
cyclooxygenase-2 22
cAMP response element binding protein 22
CSF 22
tyrosine hydroxylase 21
precursor protein 21
antioxidant enzyme 21
NR1 21
NR2A 20
neuronal nitric oxide synthase 20
Iba1 19
heme oxygenase-1 19
cannabinoid receptor 19
CA2 19
erythroid 19
phosphatase 18
glucocorticoid receptor 18
tap 18
5-HT1A 18
CAT 18
REM 17
P300 17
glucagon 17
cAMP-response element 17
ChAT 16
tropomyosin 16
neutral endopeptidase 16
ANOVA 16
SNAP 16
Apolipoprotein E 15
peroxisome proliferator-activated receptor 15
hole 15
parvalbumin 15
CA4 15
estrogen receptor 15
CB2 15
ubiquitin 15
NLRP3 14
brain-derived 14
threonine 14
dopamine D1 receptor 14
postsynaptic density protein 95 13
proteasome 13
caspase-9 13
IL-1 13
CD11b 13
BACE 13
amyloid protein 13
muscarinic acetylcholine receptor 13
IRS-1 13
ACS 13
Gen 13
Pol 13
5-HT2A 13
tyrosine kinase 13
GABA(A) receptor 13
somatostatin 13
IL-4 13
glutathione reductase 12
metabotropic glutamate receptor 12
PPAR 12
insulin receptor 12
Brain-derived neurotrophic factor 12
receptor kinase 12
PBS 12
more...
Disease
memory impairment 7237
Alzheimer's disease 2036
cognitive impairment 1234
dementia 941
depression 497
amnesia 345
epilepsy 257
schizophrenia 251
Parkinson's disease 177
GSH 157
stroke 147
ischemia 130
diabetes 128
cognitive deficit 112
temporal lobe epilepsy 108
cerebral ischemia 107
encephalitis 91
psychosis 91
multiple sclerosis 88
plaque 88
forgetting 76
posttraumatic stress disorder 71
confusion 70
disorientation 66
obesity 66
major depressive disorder 64
retrograde amnesia 60
hallucinations 60
hypertension 58
cancer 58
aphasia 56
brain atrophy 53
encephalopathy 52
anterograde amnesia 50
tumor 48
status epilepticus 48
mental illness 45
apraxia 43
fits 40
type 2 diabetes 39
brain dysfunction 39
Huntington's disease 38
delusions 37
Korsakoff's syndrome 35
parkinsonism 35
HIV 33
hyperglycemia 32
memory disorder 32
amnesic syndrome 32
autism 31
Evans 31
Down syndrome 31
Williams syndrome 31
WMS 30
WMS 30
neuroblastoma 28
aggression 28
chronic pain 27
transient global amnesia 27
hydrocephalus 26
senile dementia 26
amyotrophic lateral sclerosis 26
alcoholism 25
meningitis 24
sleep disorders 24
delirium 24
bipolar disorder 23
NAME 22
sleep disturbances 21
cognitive disorder 21
hypothyroidism 20
coma 20
mental retardation 20
AIDS 20
vascular disease 20
glioma 19
addiction 19
mental retardation 18
agnosia 18
sepsis 18
disinhibition 18
anhedonia 18
sepsis 18
ADHD 18
mania 17
herpes simplex 17
anxiety disorders 17
hepatic encephalopathy 17
psychological stress 17
systemic lupus erythematosus 16
breast cancer 16
anosognosia 16
affective disorder 16
amyloidosis 16
ECT 15
cold 15
obsessive-compulsive disorder 15
Dementia with Lewy bodies 15
cerebral infarction 15
Postoperative cognitive dysfunction 15
hemiparesis 15
incontinence 14
brain disorder 14
catalepsy 14
neuroticism 14
encephalomyelitis 13
Pick's disease 13
Vascular dementia 13
anomia 13
motor neuron disease 13
Limbic encephalitis 13
hypoglycemia 12
Brown 12
PCP 12
drug abuse 12
cardiovascular disease 12
heart failure 12
migraine 12
Cannabis 12
metabolic syndrome 11
SCH 11
hypercholesterolemia 11
drug addiction 11
emotionality 11
neuropathy 11
malnutrition 11
progressive supranuclear palsy 11
subarachnoid hemorrhage 11
neurological disease 11
hyperhomocysteinemia 10
asthma 10
hyperlipidemia 10
alcohol abuse 10
leukoencephalopathy 10
dysphasia 10
fibromyalgia 10
mutism 10
THC 10
Blocking 10
immunodeficiency 10
movement disorder 10
autoimmune disease 9
infectious diseases 9
hyperinsulinemia 9
cirrhosis 9
PDE 9
FAS 9
multi-infarct dementia 9
Autism 9
perseveration 9
behavior disorder 9
Wernicke's encephalopathy 9
drug withdrawal 8
intellectual impairment 8
brain edema 8
meningoencephalitis 8
atherosclerosis 8
West 8
Frontotemporal dementia 8
Streptococcus pneumoniae meningitis 8
more...
Symptom
seizures 283
memory loss 234
pain 94
anesthesia 87
headache 70
insomnia 69
fatigue 60
sleepiness 37
agitation 36
ataxia 34
weakness 33
apathy 29
tremor 28
analgesia 26
forgetfulness 24
functional recovery 24
dizziness 22
hypothermia 20
acute stress 18
vomiting 18
personality change 16
nausea 15
myoclonus 14
distraction 13
bradykinesia 13
anorexia 13
dysarthria 13
incoordination 12
thinning 11
diarrhea 11
vertigo 10
abnormal gait 9
dystonia 9
cerebellar ataxia 8
arthralgia 7
paraparesis 7
Psychiatric symptoms 7
hypersomnia 6
constipation 6
collapse 6
Depressive symptoms 6
paresis 6
catatonia 6
blackout 6
lethargy 5
stigma 5
hypercapnia 5
tinnitus 5
cough 5
despair 5
spasticity 5
hemiplegia 5
myalgia 5
overweight 4
numbness 4
chorea 4
Neuropathic pain 4
hangover 3
fasciculation 3
ataxic gait 3
neurological disability 3
paresthesia 3
hyperemesis gravidarum 3
muscle rigidity 3
nausea and vomiting 3
clumsiness 3
Behavioral symptoms 3
tonic-clonic seizure 2
lightheadedness 2
discomfort 2
discomfort 2
Gastrointestinal symptoms 2
exhaustion 2
loss of taste 2
twitching 2
ophthalmoplegia 2
orofacial pain 2
shortness of breath 2
consciousness disturbance 2
Poor sleep 2
dysesthesia 2
syncope 2
aphonia 2
dyspnea 2
abdominal pain 2
feeling depressed 2
Rebound insomnia 2
asthenia 2
blurred vision 2
night sweats 2
visual hallucination 2
urinary frequency 2
chest pain 2
decreased appetite 2
erythema 2
back pain 2
neck stiffness 1
hot flashes 1
cancer pain 1
abdominal cramps 1
hunger 1
partial seizure 1
Prodrome 1
polydipsia 1
Sedation 1
snoring 1
orthopnea 1
jaw pain 1
spasm 1
physical symptom 1
leg pain 1
splenomegaly 1
menopausal symptoms 1
meningism 1
Spastic 1
general problem 1
photopsia 1
muscle cramps 1
No adverse effect 1
exertional dyspnea 1
clonus 1
tense 1
alexithymia 1
Decreased activity 1
starvation 1
cyanosis 1
angina 1
motor symptom 1
rhinorrhea 1
adipsia 1
intention tremor 1
pallor 1
elevated mood 1
Multiple symptoms 1
bewilderment 1
acidity 1
Ill 1
Involuntary Movement 1
sore throat 1
polyuria 1
mental fatigue 1
metamorphopsia 1
respiratory distress 1
disturbed balance 1
amimia 1
nasal congestion 1
Mills 1
Wind 1
impaired motor coordination 1
tingling 1
hyperoxia 1
flushing 1
Drop attacks 1
hepatomegaly 1
Drug
Scopolamine 67
ROS 45
caffeine 33
Donepezil 27
CSF 24
Ethanol 17
Spectrum 12
Frontal 12
PCP 12
lysine 12
Piracetam 11
Propofol 10
ascorbate 9
Ginseng 9
Leaf 8
p75 8
Portal 8
vitamin E 7
Glutathione 4
ALA 4
Perindopril 4
THA 4
Zonisamide 4
Liraglutide 4
DHT 4
Triazolam 4
Vitamin E 4
Clonidine 4
TTC 4
Vinpocetine 4
DHT 4
Pilocarpine 4
Monit 4
Estrogens 4
Bifidobacterium 4
FAD 4
Simvastatin 4
9-THC 4
Rosiglitazone 3
Histamine 3
Atropine 3
Asn 3
EPA 3
Modafinil 3
Cilostazol 3
Cardiovasc 3
ROC 3
Parkin 3
TMS 3
Phenytoin 3
Parkin 3
Idebenone 3
Reserpine 3
Kainic acid 3
TAK 3
Hydergine 2
Heme 2
Agomelatine 2
Phosphatidylserine 2
MAP 2
Arsenic trioxide 2
Gel 2
Fluorescein 2
NVP 2
EE2 2
Moclobemide 2
Methylene blue 2
Angiotensin II 2
Indomethacin 2
Fipronil 2
Vitamin A 2
TAC 2
Aricept 2
Flunitrazepam 2
Monosodium glutamate 2
Ziconotide 2
Asthma 2
G-CSF 2
Safflower 2
Nilvadipine 2
IL-2 2
Aminoguanidine 2
DEX 2
Dermatol 2
IL-1ra 2
Escitalopram 2
Ginger 2
Hoelen 2
Cetrorelix 2
Horizon 1
Vitamin K2 1
Doxycycline 1
Acyclovir 1
Vardenafil 1
Fructose 1
CCL 1
Poloxamer 1
Lenalidomide 1
Exenatide 1
Flurothyl 1
Artesunate 1
Glycyrrhiza 1
Acthar 1
Rimonabant 1
ETA 1
Roflumilast 1
Sesamol 1
Swertia 1
Bumetanide 1
Atomoxetine 1
DFP 1
Forskolin 1
AraC 1
Rolipram 1
NBT 1
CFS 1
Sinemet 1
Dexibuprofen 1
DBS 1
Spiegel 1
Interferon beta 1
Gabapentin 1
Spectrum 1
Tao 1
Podophyllum 1
Kaolin 1
Finasteride 1
Morphine sulfate 1
Indeloxazine hydrochloride 1
Retinoic acid 1
Rutin 1
Maxipost 1
Ulinastatin 1
Areca 1
Mudanpi 1
Cobalamin 1
Flurazepam 1
Insulin glargine 1
Tubocurarine 1
Cantor 1
Rosuvastatin 1
Bv2 1
Myricetin 1
Alliance 1
ADM 1
citric acid 1
Ambien 1
Domperidone 1
Amifostine 1
Nadolol 1
Minocin 1
SR 57746A 1
nitroglycerin 1
GEO 1
Galactose 1
MDM 1
MDS 1
Pregabalin 1
Narcan 1
Vitamin B 1
more...
Enzyme
acetylcholinesterase 367
superoxide dismutase 222
protein kinase 142
catalase 142
mitogen-activated protein kinase 123
caspase-3 118
cholinesterase 105
glutathione peroxidase 103
choline acetyltransferase 84
GSK 52
ERK 50
protein kinase C 45
calcineurin 32
CaMKII 31
ATPase 29
phosphodiesterase 28
monoamine oxidase 21
tyrosine hydroxylase 21
CD10 17
PARP 16
AMP-activated protein kinase 15
proteasome 14
NOS 14
ACS 13
ACE 13
peroxidase 13
PCP 12
glutathione reductase 12
MEK 11
caspase-9 11
AMPK 11
focal adhesion kinase 10
PDE 10
caspase-1 10
insulin-degrading enzyme 10
lactate dehydrogenase 9
protein phosphatase 2A 8
cytochrome oxidase 8
creatine kinase 8
NADPH oxidase 8
NADPH oxidase 8
AMPK 7
phospholipase A2 7
NO synthase 7
beta-secretase 7
reverse transcriptase 7
complex I 6
CDR 6
glutathione S-transferase 6
methylenetetrahydrofolate reductase 6
luciferase 6
methylenetetrahydrofolate reductase 6
adenosine deaminase 6
adenosine deaminase 6
renin 5
tissue plasminogen activator 5
phosphoinositide 3-kinase 5
prolyl endopeptidase 5
succinate dehydrogenase 5
DAT 5
PKG 5
glutamine synthetase 5
alanine aminotransferase 5
tryptophan hydroxylase 5
gamma-glutamylcysteine synthetase 4
arginine decarboxylase 4
cathepsin B 4
arginine decarboxylase 4
aspartate aminotransferase 4
5'-nucleotidase 3
TMT 3
PRE 3
CYP3A4 3
arginase 3
pyruvate dehydrogenase 3
Thy1 3
phosphatidylinositol 3-kinase 3
MIP 3
phospholipase C 3
AST 3
xanthine oxidase 3
monoacylglycerol lipase 3
glutamate decarboxylase 3
heme oxygenase 3
glutamate dehydrogenase 3
glutamate dehydrogenase 3
NQO1 3
glutamate dehydrogenase 3
P-glycoprotein 3
lipoxygenase 2
RNA polymerase 2
caspase-8 2
ATP synthase 2
PAL 2
demethylase 2
APC 2
histone acetyltransferase 2
plasmin 2
furin 2
neuropsin 2
carbonic anhydrase 2
glyceraldehyde-3-phosphate dehydrogenase 2
SpeB 2
proteinase K 2
MAP 2
delta-aminolevulinic acid dehydratase 2
phosphorylase 2
glyceraldehyde-3-phosphate dehydrogenase 2
lipoprotein lipase 2
collagenase 2
DCF 2
glutaminyl cyclase 2
cathepsin D 2
NADH dehydrogenase 2
prostaglandin synthetase 2
diaphorase 2
TdT 2
serine racemase 2
cdc2 2
tryptophan 2,3-dioxygenase 2
pepsin 2
transcriptase 1
mu-calpain 1
SDMT 1
HOA 1
m-calpain 1
STK 1
PAL 1
caspase-2 1
thymidylate synthase 1
CPM 1
AMP-activated kinase 1
caspase-7 1
proprotein convertase 1
isopeptidase 1
subtilisin 1
myrosinase 1
lysine acetyltransferase 1
cysteine synthase 1
methionine synthase 1
caspase-7 1
pyruvate kinase 1
Alternating 1
NMT 1
caspase-2 1
adenylate cyclase 1
beta-galactosidase 1
type 1 protein phosphatase 1
prolyl hydroxylase 1
peroxiredoxin 1
prostate-specific antigen 1
ECH 1
granzyme B 1
DTA 1
factor C 1
cystathionine beta-synthase 1
micrococcal nuclease 1
TSA 1
nucleotidase 1
proprotein convertase 2 1
more...
Compound
water 1182
Dec 437
Clin 385
glutamate 189
oxygen 171
TNF 167
glucose 166
GSH 158
GSH 158
ethanol 133
calcium 114
nitric oxide 97
DNA 97
GABA 96
GABA 96
NMDA 85
cAMP 78
galactose 75
5-HT 74
SEE 68
sodium 66
DSM 43
ATP 42
AMPA 40
arginine 39
MDA 39
Neuronal 39
GSSG 36
His 34
caffeine 33
STZ 31
potassium 29
aluminum 29
hydrogen 29
leucine 28
tyrosine 28
gamma-aminobutyric acid 27
Cereb 26
AMP 25
iron 25
tryptophan 25
threonine 24
phosphate 24
serine 24
noradrenaline 24
methionine 23
acetate 23
Nicotine 23
tryptophan 23
Insulin 23
dUTP 22
tryptophan 22
tryptophan 22
homocysteine 21
Melatonin 21
CO2 20
ACh 20
zinc 20
Memantine 19
CAT 19
cGMP 19
CAT 18
CAT 18
fluorine 18
Sevoflurane 18
copper 17
Ketamine 17
lysine 15
bromide 14
nicotinamide 14
Curcumin 14
H2S 13
ACS 13
aspartic acid 13
ACS 13
Morphine 12
Estrogen 12
PCP 12
Malondialdehyde 12
nitrate 12
Estrogen 12
toluene 12
Quetiapine 12
pyridine 12
MPTP 12
NAD 12
Glutamate 12
Resveratrol 11
ADP 11
Letter 11
manganese 11
TBI 11
Propofol 11
Asp 11
MTT 11
cadmium 10
Methamphetamine 10
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 10
nitrogen 10
Cardiol 10
Lead 10
ethyl acetate 10
NAD 10
sulfate 10
Diazepam 10
Corticosterone 10
MK801 9
N-acetylcysteine 9
ADP 9
ADP 9
Clozapine 9
Minocycline 9
MEK 9
selenium 9
DHA 9
gallic acid 9
formaldehyde 9
8-OHdG 9
Glycogen synthase 8
iodine 8
Salt 8
dipropyl 8
valine 8
Physostigmine 8
Okadaic acid 8
Lithium 8
Histone 8
Congo red 8
Gly 8
Quercetin 8
piperazine 8
PAC 8
TOF 8
phenol 8
Dopamine 8
aspartic acid 8
cysteine 7
Isoflurane 7
H2S 7
N-acetylaspartate 7
Naringin 7
L-carnitine 7
urea 7
formaldehyde 7
DHA 7
glycerol 7
glutamic acid 7
FK506 7
creatinine 7
salt 7
butyric acid 7
DHA 7
isoleucine 6
Adenosine 6
silver 6
DMSO 6
Methylphenidate 6
Phe 6
retinoic acid 6
Sulforaphane 6
more...