Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0233565 (bradykinesia)
 2,352 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
KIAA1024L 13.7
BBG-TCC 12.7
USP31 10.7
ATP1B4 10.7
phosphodiesterase 8B 10.4
SNCAIP 9.7
CHD6 9.6
ANO10 9.6
STX6 9.5
NMD3 9.4
Kufor-Rakeb syndrome 9.2
IRX2 9.1
PANK2 9.1
HNMT 9.0
Synaptojanin 1 9.0
calmodulin-like skin protein 8.9
with Parkinsonism 8.8
CHCHD2 8.8
CIT 8.7
PKAN 8.7
Alpha synuclein 8.7
ATP13A2 8.7
vacuolar protein sorting 35 8.7
F-box only protein 7 8.7
PARK8 8.7
STN 8.6
SCA8 8.6
Hallervorden-Spatz syndrome 8.6
USP30 8.5
KCNJ6 8.5
SCA17 8.5
EIF4G1 8.4
STK39 8.4
DYT11 8.4
DBS 8.3
LRRK2 8.3
PRKACB 8.2
MOBP 8.2
Dopamine transporter 8.1
SV2C 8.1
MUL1 8.1
PARK7 8.1
SLC18A2 8.0
dopa-responsive dystonia 8.0
DCI 8.0
AFG3L2 7.9
iron regulatory protein 2 7.9
leucine-rich repeat kinase 2 7.6
SNCA 7.6
Engrailed-2 7.6
alpha synuclein 7.6
HTR2C 7.5
PSP 7.5
GPR37 7.5
TMEM106B 7.4
5-HT-1A 7.4
NADH: ubiquinone oxidoreductase 7.4
PABP1 7.3
Leucine-rich repeat kinase 2 7.3
Monoamine oxidase B 7.3
pantothenate kinase 7.3
RET protein 7.3
GCH1 7.2
TRIM24 7.2
5-HT6 7.2
PARK6 7.2
CHMP2B 7.2
parkin 7.2
spinocerebellar ataxia type 2 7.2
colony stimulating factor 1 receptor 7.2
SCA2 7.2
catechol O-methyltransferase 7.2
glial cell derived neurotrophic factor 7.1
amylase 1 7.1
DTN 7.1
Frataxin 7.1
ddc 7.0
MSA 7.0
synuclein 7.0
N33 7.0
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Disease
Pallidonigral degeneration 13.7
early parkinson's 13.7
Bradyphrenia 13.1
Supranuclear gaze palsy 12.7
SCAR6 12.1
CRCL 12.1
Secondary parkinsonism 11.9
Vascular parkinsonism 11.7
PARK12 11.4
Striatonigral degeneration 11.3
SCA21 11.1
Vertical gaze palsy 10.7
PARK3 10.6
hemiparkinsonism 10.3
Juvenile Parkinsonism 10.3
organic delusional syndrome 10.3
CNS degenerative disease 10.3
Ideational apraxia 10.3
mild memory disturbance 10.0
organic personality syndrome 10.0
Parkinson's disease and parkinsonism 10.0
akinesia 10.0
Ideomotor apraxia 9.8
Corticobasal degeneration 9.6
Cerebellar degeneration 9.3
REM sleep behavior disorder 9.1
camptocormia 9.0
PARK8 9.0
parkinsonism 8.9
dysbasia 8.9
Progressive dementia 8.9
pseudobulbar palsy 8.9
dyskinesia 8.8
anarthria 8.6
extrapyramidal disorder 8.6
movement disorder 8.5
Parkinson's disease 8.5
DYT11 8.5
progressive supranuclear palsy 8.5
SCA17 8.4
basal ganglia disease 8.4
Hallervorden-Spatz disease 8.4
abnormal involuntary movements 8.1
Cranial nerves 8.0
Cranial nerves 8.0
Multiple system atrophy 8.0
Pontocerebellar hypoplasia 8.0
KRS 7.9
impulse control disorder 7.8
SCA8 7.8
delusions of persecution 7.8
psycho-organic syndrome 7.8
apraxia 7.7
Globus 7.7
Demented 7.7
Dementia with Lewy bodies 7.6
Dystonia 7.6
olivopontocerebellar atrophy 7.6
PSP 7.5
Pure autonomic failure 7.5
adult HD 7.5
cerebral degeneration 7.4
mutism 7.4
dysautonomia 7.4
Essential tremor 7.4
choreoathetosis 7.3
autonomic disorder 7.3
PARK7 7.3
catalepsy 7.3
Cerebral metastases 7.2
Autoimmune encephalitis 7.1
SCA2 7.1
flat affect 7.1
Binswanger 7.1
encephalomyelopathy 7.1
PARK6 7.0
primary lateral sclerosis 7.0
MSA 7.0
blunted affect 6.8
motor aphasia 6.8
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Symptom
Cog-wheel rigidity 13.7
bradykinesia 13.7
Freezing phenomenon 12.7
Fine tremor 12.7
Marked rigidity 12.1
Extrapyramidal rigidity 12.1
Rest tremor 11.6
impaired body balance 11.4
Antecollis 10.9
Parkinsonian rest tremor 10.7
motor symptom 10.4
muscle rigidity 10.2
tremor 9.8
Postural tremor 9.6
waxy flexibility 9.5
Extrapyramidal symptoms 9.4
abnormal gait 8.4
chorea 8.4
hemihypesthesia 8.1
dystonia 8.1
abnormal reflex 7.9
dysarthria 7.9
Decreased activity 7.7
Involuntary Movement 7.6
Kayser-Fleischer ring 7.5
clumsiness 7.4
Behavioral symptoms 7.4
Motor dysfunction 7.4
Parkinsonian tremor 7.3
athetosis 7.3
Fear of falling 7.2
Fear of falling 7.2
asterixis 7.0
myoclonus 6.9
ataxic gait 6.9
drooling 6.9
blepharospasm 6.7
excessive sweating 6.6
apathy 6.5
catatonia 6.4
cerebellar ataxia 6.4
intention tremor 6.3
hypertonia 6.2
arm weakness 6.2
personality change 6.2
adipsia 6.2
Lower urinary tract symptoms 6.2
aphagia 6.1
forgetfulness 5.9
disturbed balance 5.9
ataxia 5.9
aphonia 5.8
incoordination 5.7
ophthalmoplegia 5.7
memory loss 5.7
auditory hallucination 5.7
spasticity 5.7
consciousness disturbance 5.6
lassitude 5.6
visual hallucination 5.6
muscle stiffness 5.5
thirsty 5.4
Psychiatric symptoms 5.4
constipation 5.3
eds 5.3
prostration 5.2
anosmia 5.1
paraparesis 5.1
torticollis 5.1
pallor 5.0
fasciculation 5.0
muscle cramps 4.9
sleepiness 4.8
insomnia 4.7
retching 4.6
urinary frequency 4.6
Fluctuation 4.5
tonic-clonic seizure 4.4
Sedation 4.3
partial seizure 4.3
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Drug
Tandospirone citrate 12.1
Flunarizine hydrochloride 11.7
Dophamine 11.1
Succinobucol 10.7
Bupleurum root 10.6
Lergotrile mesylate 10.6
Mirapex 10.3
Lergotrile 10.2
Blonanserin 10.0
Sinemet 9.9
Sinemet 9.7
Droxidopa 9.2
Benserazide 9.0
Istradefylline 9.0
Madopar 8.9
Sinemet 8.8
Topamax 8.8
Eldepryl 8.8
Metoclopramide hydrochloride 8.7
Eldepryl 8.6
Azilect 8.4
DBS 8.3
Lisuride 8.2
Parlodel 8.1
Rasagiline 8.0
Tianma 8.0
Carbidopa 8.0
Parlodel 8.0
Primperan 7.7
3,4-Dihydroxyphenylalanine 7.4
Rosin 7.2
Sodium benzoate 7.1
Safflower 6.8
MDS 6.6
Moclobemide 6.2
Pramipexole 6.0
Apomorphine 6.0
Pramipexole 6.0
Parkin 5.7
Parkin 5.7
CFT 5.5
Donepezil 4.6
Frontal 4.3
Tocopherol 4.3
Posture 4.1
Bupivacaine 4.1
Android 4.1
NVP 3.8
Reserpine 3.8
DM1 3.1
Triclosan 3.1
Diurnal 3.0
niacin 2.8
Portal 2.7
uPA 2.7
Dakar 2.7
TMS 2.5
pyridoxal phosphate 2.4
CSF 2.4
HCG 2.3
ICI 2.3
PCP 1.9
caffeine 1.3
CTX 1.3
CTX 1.2
vitamin E 1.2
ascorbate 0.8
ROC 0.8
Spectrum 0.8
ENT 0.7
ROS 0.5
citric acid 0.5
CTX 0.4
MAP -0.2
NADH -0.7
Monit -1.4
Enzyme
pantothenate kinase 7.8
nicotinamide N-methyltransferase 7.2
catechol O-methyltransferase 6.7
GD3 synthase 6.2
MPP 6.0
DAT 6.0
tyrosine hydroxylase 5.9
DOPA decarboxylase 5.3
monoamine oxidase 5.1
cyclohydrolase 5.0
CNPase 4.7
isopeptidase 4.6
myrosinase 4.6
aldehyde oxidase 4.2
FAST 4.2
GABA transaminase 4.1
ceruloplasmin 4.0
Thy1 3.5
heme oxygenase 3.3
glucocerebrosidase 3.2
complex I 3.2
Alternating 3.1
PAL 3.1
paraoxonase 3.0
MEKK1 2.9
paraoxonase 2.7
caspase-3 2.7
cholinesterase 2.7
PAL 2.7
phosphoglycerate kinase 2.6
caspase-9 2.4
PKG 2.4
acetylcholinesterase 2.3
proteasome 2.2
AMPK 2.1
choline acetyltransferase 2.1
granzyme B 2.0
GSK 2.0
hexosaminidase 1.9
PDE 1.9
PCP 1.8
proteinase K 1.7
cathepsin B 1.7
transglutaminase 1.5
aldehyde dehydrogenase 1.4
AMPK 1.1
glyceraldehyde-3-phosphate dehydrogenase 1.1
AMP-activated protein kinase 1.1
superoxide dismutase 1.1
papain 1.0
NOS 0.9
beta-galactosidase 0.9
glutathione peroxidase 0.9
MAP 0.9
succinate dehydrogenase 0.7
guanylate cyclase 0.7
phosphodiesterase 0.5
glutathione reductase 0.5
CD10 0.5
NADPH oxidase 0.4
urokinase-type plasminogen activator 0.3
phosphatidylinositol 3-kinase 0.3
catalase 0.3
ACS 0.3
NADPH oxidase 0.3
tissue plasminogen activator 0.3
protein kinase 0.2
ATPase 0.1
P-glycoprotein 0.0
PARP -0.0
mitogen-activated protein kinase -0.2
calcineurin -0.3
MEK -0.4
creatine kinase -0.5
ERK -0.5
protein kinase C -0.9
lactate dehydrogenase -1.1
peroxidase -1.3
Compound
tris(2-chloropropyl) phosphate 10.9
1-benzyl-1,2,3,4-tetrahydroisoquinoline 9.7
nicotinaldehyde 9.3
nicotinaldehyde 9.3
nicotinaldehyde 9.3
nicotinaldehyde 9.3
4-phenyl-1,2,3,6-tetrahydropyridine 9.2
nicotinaldehyde 9.2
nicotinaldehyde 9.2
nicotinaldehyde 9.1
nicotinaldehyde 9.1
nicotinaldehyde 9.0
nicotinaldehyde 9.0
Ropinirole 9.0
1,3-dihydro-2H-benzimidazol-2-one 8.7
Monoolein 8.7
nicotinaldehyde 8.6
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 8.5
MPTP 8.5
Metoclopramide hydrochloride 8.4
DBS 8.3
Biopterin 8.2
Pergolide 8.0
PDQ 8.0
L-DOPA 7.9
DCI 7.9
HFr 7.9
Biperiden 7.9
Loganin 7.7
PAPP 7.6
Selegiline 7.6
PAPP 7.4
Deguelin 7.4
PSP 7.4
1-Methyl-4-phenylpyridinium 7.2
CIT 7.2
CIT 7.1
Isatin 7.1
Amantadine 7.1
Amantadine 7.1
hydroxytyramine 7.0
Amantadine 7.0
Bromocriptine 7.0
TLA 7.0
Dopa 6.7
Amantadine 6.7
cyclohexanecarboxylic acid 6.5
cyclohexanecarboxylic acid 6.5
cyclohexanecarboxylic acid 6.5
cyclohexanecarboxylic acid 6.5
cyclohexanecarboxylic acid 6.5
Geniposide 6.4
Rotenone 6.4
Anthraquinone 6.3
MPP 6.1
NOP 6.1
MPP 6.1
1,2,3,4-tetrahydroisoquinoline 6.1
tris(2-chloroethyl) phosphate 6.1
DAT 6.0
Dopamine 6.0
3,4-dihydroxyphenylalanine 6.0
Cabergoline 5.8
Quetiapine 5.8
MPE 5.7
Ethylene oxide 5.7
Pantothenate 5.7
Paeoniflorin 5.5
Thiabendazole 5.4
MHPG 5.4
Alba 5.4
TDT 5.4
Tannin 5.3
Haloperidol 5.2
Carvacrol 5.2
MCE 5.1
Methysergide 5.1
THIP 5.1
Haloperidol 5.1
Riluzole 5.1
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