Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0233565 (bradykinesia)
 2,352 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 149
MRI 116
tyrosine hydroxylase 64
synuclein 52
She 51
Mol 46
alpha-synuclein 39
dopamine transporter 35
olfactory 32
CIT 29
LRRK2 22
Pol 22
asymmetrical 21
GABA 21
DBS 21
STN 20
ubiquitin 20
axonal 19
caspase-3 17
MAO-B 17
MDS 16
parkin 14
tau protein 13
glial cell line-derived neurotrophic factor 12
PSP 12
CSF 12
REM 11
SNCA 10
DJ-1 10
tap 10
PINK1 10
Bcl-2 10
leucine-rich repeat kinase 2 9
ATP 9
with Parkinsonism 9
proteasome 9
MPP 9
SCH 8
dopa decarboxylase 8
MSA 8
more...
Disease
Parkinson's disease 1684
parkinsonism 526
dementia 226
akinesia 175
dyskinesia 174
depression 166
movement disorder 122
cognitive impairment 122
Alzheimer's disease 106
progressive supranuclear palsy 89
Huntington's disease 76
psychosis 65
hallucinations 48
apraxia 43
dysphagia 38
sleep disorders 31
sleep disturbances 30
stroke 28
catalepsy 27
Dementia with Lewy bodies 24
encephalopathy 22
neurological disease 22
schizophrenia 21
incontinence 21
encephalitis 20
REM sleep behavior disorder 18
epilepsy 18
myelodysplastic syndrome 16
hemiparkinsonism 16
MDS 16
mutism 14
hemiparesis 14
Wilson's disease 14
confusion 14
disorientation 14
delusions 13
pneumonia 13
memory impairment 13
abnormal involuntary movements 13
diabetes 13
more...
Symptom
bradykinesia 2352
tremor 1251
dystonia 167
muscle rigidity 93
ataxia 69
dysarthria 67
chorea 51
motor symptom 47
myoclonus 39
pain 38
weakness 33
seizures 32
constipation 29
apathy 28
abnormal gait 28
sleepiness 27
fatigue 25
spasticity 24
cerebellar ataxia 22
insomnia 20
nausea 17
memory loss 14
ophthalmoplegia 13
agitation 12
Rest tremor 12
headache 12
vomiting 11
Extrapyramidal symptoms 10
dizziness 8
Decreased activity 8
blepharospasm 8
paresis 7
paraparesis 7
anesthesia 7
catatonia 7
clumsiness 7
hypertonia 7
incoordination 7
Involuntary Movement 6
dyspnea 6
more...
Drug
DBS 21
Sinemet 18
MDS 16
Sinemet 15
Sinemet 15
CSF 12
Parkin 7
Parkin 7
Posture 7
Apomorphine 6
caffeine 4
Parlodel 4
Madopar 4
Parlodel 3
Carbidopa 3
Rasagiline 3
ascorbate 3
Frontal 3
Lisuride 3
vitamin E 3
ROS 2
CFT 2
Blonanserin 2
Lergotrile 2
ICI 2
niacin 2
Benserazide 2
Portal 2
Android 1
Tianma 1
MAP 1
Eldepryl 1
CTX 1
citric acid 1
Tocopherol 1
NADH 1
Dophamine 1
Azilect 1
Dakar 1
Triclosan 1
more...
Enzyme
tyrosine hydroxylase 63
monoamine oxidase 28
caspase-3 17
acetylcholinesterase 10
proteasome 10
superoxide dismutase 9
MPP 9
DAT 7
protein kinase 7
ACS 7
ceruloplasmin 6
complex I 6
cholinesterase 6
mitogen-activated protein kinase 6
catalase 5
ATPase 5
ERK 5
pantothenate kinase 4
heme oxygenase 3
catechol O-methyltransferase 3
caspase-9 3
DOPA decarboxylase 3
glutathione peroxidase 3
choline acetyltransferase 2
AMP-activated protein kinase 2
AMPK 2
phosphodiesterase 2
beta-galactosidase 2
peroxidase 2
GSK 2
protein kinase C 2
AMPK 2
granzyme B 1
cyclohydrolase 1
glutathione reductase 1
lactate dehydrogenase 1
phosphatidylinositol 3-kinase 1
GABA transaminase 1
aldehyde dehydrogenase 1
creatine kinase 1
more...
Compound
L-DOPA 161
Dec 153
Clin 140
MPTP 135
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 86
Dopamine 41
His 35
glutamate 31
CIT 29
CIT 29
oxygen 27
manganese 26
iron 23
DBS 21
GABA 21
GABA 21
water 19
DNA 18
calcium 17
5-HT 16
Dopa 14
glucose 13
noradrenaline 13
PSP 12
Neuronal 12
4-phenyl-1,2,3,6-tetrahydropyridine 11
Bromocriptine 10
MPP 9
nitric oxide 9
MPP 9
ATP 9
potassium 8
PDQ 8
NMDA 7
ACS 7
gamma-aminobutyric acid 7
DAT 7
copper 7
ACS 7
Haloperidol 6
more...