Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0233565 (bradykinesia)
 2,352 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
KIAA1024L 13.7
BBG-TCC 12.7
ATP1B4 10.7
USP31 10.7
phosphodiesterase 8B 10.4
SNCAIP 9.7
CHD6 9.6
ANO10 9.6
STX6 9.5
NMD3 9.4
Kufor-Rakeb syndrome 9.2
IRX2 9.1
PANK2 9.1
HNMT 9.0
Synaptojanin 1 9.0
calmodulin-like skin protein 8.9
with Parkinsonism 8.8
CHCHD2 8.8
CIT 8.7
ATP13A2 8.7
Alpha synuclein 8.7
PARK8 8.7
PKAN 8.7
vacuolar protein sorting 35 8.7
F-box only protein 7 8.7
STN 8.6
SCA8 8.6
Hallervorden-Spatz syndrome 8.6
KCNJ6 8.5
USP30 8.5
SCA17 8.5
EIF4G1 8.4
STK39 8.4
DYT11 8.4
DBS 8.3
LRRK2 8.3
PRKACB 8.2
MOBP 8.2
Dopamine transporter 8.1
SV2C 8.1
MUL1 8.1
PARK7 8.1
SLC18A2 8.0
dopa-responsive dystonia 8.0
DCI 8.0
AFG3L2 7.9
iron regulatory protein 2 7.9
leucine-rich repeat kinase 2 7.6
SNCA 7.6
Engrailed-2 7.6
alpha synuclein 7.6
HTR2C 7.5
PSP 7.5
GPR37 7.5
TMEM106B 7.4
NADH: ubiquinone oxidoreductase 7.4
5-HT-1A 7.4
PABP1 7.3
Leucine-rich repeat kinase 2 7.3
Monoamine oxidase B 7.3
pantothenate kinase 7.3
RET protein 7.3
GCH1 7.2
TRIM24 7.2
5-HT6 7.2
PARK6 7.2
CHMP2B 7.2
parkin 7.2
spinocerebellar ataxia type 2 7.2
colony stimulating factor 1 receptor 7.2
SCA2 7.2
catechol O-methyltransferase 7.2
glial cell derived neurotrophic factor 7.1
amylase 1 7.1
DTN 7.1
Frataxin 7.1
ddc 7.0
MSA 7.0
synuclein 7.0
N33 7.0
alpha-synuclein 7.0
PARKIN 7.0
Arylsulfatase A 6.9
EIF2AK3 6.9
synphilin-1 6.8
MFT 6.8
SCA1 6.8
DUSP5 6.8
IRP2 6.8
TAC1 6.8
IRP1 6.7
dopamine transporter 6.7
DJ-1 6.7
SRO 6.7
PINK1 6.7
PPX 6.7
MDS 6.6
ATP1A3 6.5
SCA3 6.5
MAO-B 6.5
OMD 6.5
GD3 synthase 6.5
SLC6A3 6.5
mGluR4 6.4
jerky 6.4
SIRT5 6.4
hnRNPA1 6.4
neurturin 6.4
COMT 6.4
PSG 6.3
NST 6.3
IPT 6.3
ferroportin 1 6.3
SYP 6.2
Nicotinamide N-methyltransferase 6.2
VMAT2 6.2
VPS35 6.2
TH protein 6.2
RARS 6.2
S100beta 6.2
MPP 6.2
MAOB 6.1
vesicular monoamine transporter 2 6.1
Presenilin 1 6.1
glial cell line-derived neurotrophic factor 6.1
NRM 6.1
Interleukin 4 6.1
DAT 6.0
catechol-O-methyltransferase 5.9
NFKBIA 5.9
GCH 5.9
ubiquitin C-terminal hydrolase 5.9
NR4A2 5.9
UCHL1 5.9
AG1 5.9
MTH1 5.9
SUMO-2 5.9
GRN 5.9
malin 5.9
DRD2 5.9
PSEN1 5.9
HS3 5.8
NRG 5.8
tyrosine hydroxylase 5.8
transferrin receptor 2 5.8
UCH-L1 5.8
SWI2 5.8
leucine-rich repeat protein 5.8
PARK2 5.8
BBS 5.8
ENA 5.7
dopa decarboxylase 5.7
GPE 5.7
HLA-B51 5.7
nuclear respiratory factor 1 5.7
activator 1 5.7
Parkin 5.7
HDS 5.7
tre 5.6
neurotrophin-4 5.6
more...
Disease
early parkinson's 13.7
Pallidonigral degeneration 13.7
Bradyphrenia 13.1
Supranuclear gaze palsy 12.7
SCAR6 12.1
CRCL 12.1
Secondary parkinsonism 11.9
Vascular parkinsonism 11.7
PARK12 11.4
Striatonigral degeneration 11.3
SCA21 11.1
Vertical gaze palsy 10.7
PARK3 10.6
hemiparkinsonism 10.3
CNS degenerative disease 10.3
organic delusional syndrome 10.3
Ideational apraxia 10.3
Juvenile Parkinsonism 10.3
mild memory disturbance 10.0
Parkinson's disease and parkinsonism 10.0
organic personality syndrome 10.0
akinesia 10.0
Ideomotor apraxia 9.8
Corticobasal degeneration 9.6
Cerebellar degeneration 9.3
REM sleep behavior disorder 9.1
camptocormia 9.0
PARK8 9.0
parkinsonism 8.9
Progressive dementia 8.9
dysbasia 8.9
pseudobulbar palsy 8.9
dyskinesia 8.8
anarthria 8.6
extrapyramidal disorder 8.6
movement disorder 8.5
Parkinson's disease 8.5
DYT11 8.5
progressive supranuclear palsy 8.5
SCA17 8.4
basal ganglia disease 8.4
Hallervorden-Spatz disease 8.4
abnormal involuntary movements 8.1
Cranial nerves 8.0
Cranial nerves 8.0
Multiple system atrophy 8.0
Pontocerebellar hypoplasia 8.0
KRS 7.9
impulse control disorder 7.8
delusions of persecution 7.8
SCA8 7.8
psycho-organic syndrome 7.8
apraxia 7.7
Globus 7.7
Demented 7.7
Dementia with Lewy bodies 7.6
Dystonia 7.6
olivopontocerebellar atrophy 7.6
PSP 7.5
Pure autonomic failure 7.5
adult HD 7.5
cerebral degeneration 7.4
mutism 7.4
dysautonomia 7.4
Essential tremor 7.4
choreoathetosis 7.3
autonomic disorder 7.3
PARK7 7.3
catalepsy 7.3
Cerebral metastases 7.2
Autoimmune encephalitis 7.1
SCA2 7.1
flat affect 7.1
Binswanger 7.1
encephalomyelopathy 7.1
PARK6 7.0
primary lateral sclerosis 7.0
MSA 7.0
blunted affect 6.8
motor aphasia 6.8
DRD 6.8
pediatric HD 6.8
TSH deficiency 6.8
HIV encephalopathy 6.8
SCA1 6.7
Machado-Joseph disease 6.7
Parinaud's syndrome 6.7
acanthocytosis 6.7
Neurodegenerative Disorders 6.6
Meige syndrome 6.6
acalculia 6.6
actinomycetoma 6.5
hemichorea 6.5
Ritual 6.5
Familial hemiplegic migraine 6.5
MDS 6.5
hallucinations 6.4
Frontotemporal dementia 6.4
behavior disorder 6.4
intellectual impairment 6.3
cognitive disorder 6.3
retrobulbar neuritis 6.3
anomia 6.3
Wilson's disease 6.3
cerebellar syndrome 6.2
Huntington's disease 6.2
echolalia 6.2
Toxoplasma encephalitis 6.2
disorientation 6.2
sleep disturbances 6.2
vCJD 6.2
Fahr's disease 6.1
Spinocerebellar ataxia 6.1
tardive dyskinesia 6.1
FTLD 6.1
agnosia 6.1
Pick's disease 6.1
Inborn errors of metabolism 6.1
public drinking 6.1
Lissauer 6.0
SCA6 6.0
Neonatal sepsis 6.0
speech disorder 6.0
restless legs syndrome 6.0
Herpes simplex encephalitis 6.0
hypoadrenocorticism 6.0
sleep disorders 5.9
NMS 5.9
asthenopia 5.9
Akathisia 5.9
GM2 gangliosidosis 5.8
torsion dystonia 5.8
dementia 5.8
Lower limb 5.7
aspiration pneumonia 5.7
PARK2 5.7
visual dysfunction 5.7
reactive depression 5.7
chondritis 5.7
complete paraplegia 5.6
Relapsing polychondritis 5.6
brain disorder 5.5
RARS 5.5
BPP 5.5
GM1 gangliosidosis 5.5
cognitive impairment 5.5
sensory disturbance 5.5
Canavan 5.5
polychondritis 5.5
dyscalculia 5.4
primary central nervous system lymphoma 5.4
Nystagmus 5.4
presenile dementia 5.4
seborrheic dermatitis 5.3
HIV encephalitis 5.3
Abdomen 5.3
AIDS dementia complex 5.3
parasomnia 5.3
Gerstmann 5.3
melancholia 5.2
more...
Symptom
Cog-wheel rigidity 13.7
bradykinesia 13.7
Fine tremor 12.7
Freezing phenomenon 12.7
Marked rigidity 12.1
Extrapyramidal rigidity 12.1
Rest tremor 11.6
impaired body balance 11.4
Antecollis 10.9
Parkinsonian rest tremor 10.7
motor symptom 10.4
muscle rigidity 10.2
tremor 9.8
Postural tremor 9.6
waxy flexibility 9.5
Extrapyramidal symptoms 9.4
abnormal gait 8.4
chorea 8.4
hemihypesthesia 8.1
dystonia 8.1
abnormal reflex 7.9
dysarthria 7.9
Decreased activity 7.7
Involuntary Movement 7.6
Kayser-Fleischer ring 7.5
clumsiness 7.4
Behavioral symptoms 7.4
Motor dysfunction 7.4
Parkinsonian tremor 7.3
athetosis 7.3
Fear of falling 7.2
Fear of falling 7.2
asterixis 7.0
myoclonus 6.9
ataxic gait 6.9
drooling 6.9
blepharospasm 6.7
excessive sweating 6.6
apathy 6.5
catatonia 6.4
cerebellar ataxia 6.4
intention tremor 6.3
hypertonia 6.2
arm weakness 6.2
personality change 6.2
adipsia 6.2
Lower urinary tract symptoms 6.2
aphagia 6.1
forgetfulness 5.9
disturbed balance 5.9
ataxia 5.9
aphonia 5.8
incoordination 5.7
ophthalmoplegia 5.7
memory loss 5.7
auditory hallucination 5.7
spasticity 5.7
consciousness disturbance 5.6
lassitude 5.6
visual hallucination 5.6
muscle stiffness 5.5
thirsty 5.4
Psychiatric symptoms 5.4
constipation 5.3
eds 5.3
prostration 5.2
anosmia 5.1
paraparesis 5.1
torticollis 5.1
pallor 5.0
fasciculation 5.0
muscle cramps 4.9
sleepiness 4.8
insomnia 4.7
retching 4.6
urinary frequency 4.6
Fluctuation 4.5
tonic-clonic seizure 4.4
Sedation 4.3
partial seizure 4.3
stridor 4.1
dysuria 4.0
paresis 4.0
neurological disability 3.9
dysesthesia 3.8
orofacial pain 3.8
agitation 3.8
hypersomnia 3.7
weakness 3.6
decreased appetite 3.5
dizziness 3.5
paresthesia 3.5
tingling 3.4
asthenia 3.4
nasal discharge 3.3
nausea 3.3
lethargy 3.2
bloating 3.0
oliguria 2.9
hypotonia 2.8
Depressive symptoms 2.8
hemiplegia 2.8
leg pain 2.7
twitching 2.7
fatigue 2.7
blurred vision 2.7
skin irritation 2.7
myalgia 2.6
functional recovery 2.6
vertigo 2.5
seizures 2.4
tachypnea 2.4
numbness 2.4
knee pain 2.3
cachexia 2.3
snoring 2.2
vomiting 2.2
nausea and vomiting 2.1
epigastric pain 2.0
anorexia 2.0
hypothermia 2.0
spasm 1.9
thinning 1.9
cyanosis 1.8
neck pain 1.8
discomfort 1.6
syncope 1.5
dyspnea 1.5
headache 1.5
wheezing 1.5
discomfort 1.5
low back pain 1.4
shortness of breath 1.4
back pain 1.2
exhaustion 1.0
pain 1.0
distraction 0.5
respiratory distress 0.5
Ill 0.3
cough 0.2
stigma 0.0
anesthesia -0.2
analgesia -1.1
collapse -1.1
diarrhea -1.1
abdominal pain -1.2
Drug
Tandospirone citrate 12.1
Flunarizine hydrochloride 11.7
Dophamine 11.1
Succinobucol 10.7
Bupleurum root 10.6
Lergotrile mesylate 10.6
Mirapex 10.3
Lergotrile 10.2
Blonanserin 10.0
Sinemet 9.9
Sinemet 9.7
Droxidopa 9.2
Benserazide 9.0
Istradefylline 9.0
Madopar 8.9
Sinemet 8.8
Topamax 8.8
Eldepryl 8.8
Metoclopramide hydrochloride 8.7
Eldepryl 8.6
Azilect 8.4
DBS 8.3
Lisuride 8.2
Parlodel 8.1
Rasagiline 8.0
Tianma 8.0
Carbidopa 8.0
Parlodel 8.0
Primperan 7.7
3,4-Dihydroxyphenylalanine 7.4
Rosin 7.2
Sodium benzoate 7.1
Safflower 6.8
MDS 6.6
Moclobemide 6.2
Pramipexole 6.0
Apomorphine 6.0
Pramipexole 6.0
Parkin 5.7
Parkin 5.7
CFT 5.5
Donepezil 4.6
Frontal 4.3
Tocopherol 4.3
Posture 4.1
Bupivacaine 4.1
Android 4.1
NVP 3.8
Reserpine 3.8
DM1 3.1
Triclosan 3.1
Diurnal 3.0
niacin 2.8
Portal 2.7
uPA 2.7
Dakar 2.7
TMS 2.5
pyridoxal phosphate 2.4
CSF 2.4
HCG 2.3
ICI 2.3
PCP 1.9
caffeine 1.3
CTX 1.3
CTX 1.2
vitamin E 1.2
ascorbate 0.8
ROC 0.8
Spectrum 0.8
ENT 0.7
ROS 0.5
citric acid 0.5
CTX 0.4
MAP -0.2
NADH -0.7
Monit -1.4
Enzyme
pantothenate kinase 7.8
nicotinamide N-methyltransferase 7.2
catechol O-methyltransferase 6.7
GD3 synthase 6.2
MPP 6.0
DAT 6.0
tyrosine hydroxylase 5.9
DOPA decarboxylase 5.3
monoamine oxidase 5.1
cyclohydrolase 5.0
CNPase 4.7
isopeptidase 4.6
myrosinase 4.6
aldehyde oxidase 4.2
FAST 4.2
GABA transaminase 4.1
ceruloplasmin 4.0
Thy1 3.5
heme oxygenase 3.3
glucocerebrosidase 3.2
complex I 3.2
Alternating 3.1
PAL 3.1
paraoxonase 3.0
MEKK1 2.9
paraoxonase 2.7
caspase-3 2.7
cholinesterase 2.7
PAL 2.7
phosphoglycerate kinase 2.6
caspase-9 2.4
PKG 2.4
acetylcholinesterase 2.3
proteasome 2.2
AMPK 2.1
choline acetyltransferase 2.1
granzyme B 2.0
GSK 2.0
hexosaminidase 1.9
PDE 1.9
PCP 1.8
proteinase K 1.7
cathepsin B 1.7
transglutaminase 1.5
aldehyde dehydrogenase 1.4
AMPK 1.1
glyceraldehyde-3-phosphate dehydrogenase 1.1
AMP-activated protein kinase 1.1
superoxide dismutase 1.1
papain 1.0
NOS 0.9
beta-galactosidase 0.9
glutathione peroxidase 0.9
MAP 0.9
succinate dehydrogenase 0.7
guanylate cyclase 0.7
phosphodiesterase 0.5
glutathione reductase 0.5
CD10 0.5
NADPH oxidase 0.4
urokinase-type plasminogen activator 0.3
phosphatidylinositol 3-kinase 0.3
catalase 0.3
ACS 0.3
NADPH oxidase 0.3
tissue plasminogen activator 0.3
protein kinase 0.2
ATPase 0.1
P-glycoprotein 0.0
PARP -0.0
mitogen-activated protein kinase -0.2
calcineurin -0.3
MEK -0.4
creatine kinase -0.5
ERK -0.5
protein kinase C -0.9
lactate dehydrogenase -1.1
peroxidase -1.3
Compound
tris(2-chloropropyl) phosphate 10.9
1-benzyl-1,2,3,4-tetrahydroisoquinoline 9.7
nicotinaldehyde 9.3
nicotinaldehyde 9.3
nicotinaldehyde 9.3
nicotinaldehyde 9.3
4-phenyl-1,2,3,6-tetrahydropyridine 9.2
nicotinaldehyde 9.2
nicotinaldehyde 9.2
nicotinaldehyde 9.1
nicotinaldehyde 9.1
nicotinaldehyde 9.0
nicotinaldehyde 9.0
Ropinirole 9.0
1,3-dihydro-2H-benzimidazol-2-one 8.7
Monoolein 8.7
nicotinaldehyde 8.6
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 8.5
MPTP 8.5
Metoclopramide hydrochloride 8.4
DBS 8.3
Biopterin 8.2
Pergolide 8.0
PDQ 8.0
L-DOPA 7.9
DCI 7.9
Biperiden 7.9
HFr 7.9
Loganin 7.7
PAPP 7.6
Selegiline 7.6
PAPP 7.4
Deguelin 7.4
PSP 7.4
1-Methyl-4-phenylpyridinium 7.2
CIT 7.2
CIT 7.1
Isatin 7.1
Amantadine 7.1
Amantadine 7.1
hydroxytyramine 7.0
Amantadine 7.0
Bromocriptine 7.0
TLA 7.0
Dopa 6.7
Amantadine 6.7
cyclohexanecarboxylic acid 6.5
cyclohexanecarboxylic acid 6.5
cyclohexanecarboxylic acid 6.5
cyclohexanecarboxylic acid 6.5
cyclohexanecarboxylic acid 6.5
Geniposide 6.4
Rotenone 6.4
Anthraquinone 6.3
MPP 6.1
NOP 6.1
MPP 6.1
1,2,3,4-tetrahydroisoquinoline 6.1
tris(2-chloroethyl) phosphate 6.1
DAT 6.0
Dopamine 6.0
3,4-dihydroxyphenylalanine 6.0
Cabergoline 5.8
Quetiapine 5.8
MPE 5.7
Ethylene oxide 5.7
Pantothenate 5.7
Paeoniflorin 5.5
Thiabendazole 5.4
MHPG 5.4
Alba 5.4
TDT 5.4
Tannin 5.3
Haloperidol 5.2
Carvacrol 5.2
MCE 5.1
Methysergide 5.1
THIP 5.1
Haloperidol 5.1
Riluzole 5.1
Methylphenidate 5.0
DDC 5.0
DDC 5.0
Olanzapine 4.9
Citalopram 4.9
Cannabidiol 4.8
PDP 4.8
Crystal Violet 4.8
TDP 4.8
BDS 4.8
NFS 4.7
CAA 4.7
methylformamide 4.7
HVA 4.6
Coronal 4.5
galanthamine 4.3
Tramadol 4.3
TAR 4.3
Metoclopramide 4.2
5-HIAA 4.2
Bupivacaine 4.2
coenzyme Q10 4.1
Muscimol 4.1
Docosahexaenoic acid 4.0
DDC 3.9
DOPAC 3.9
Pima 3.9
Neuronal 3.8
Minocycline 3.8
Valproic acid 3.7
neopterin 3.7
IMP 3.7
Epigallocatechin gallate 3.7
A 71 3.6
Dipyridamole 3.6
Dipyridamole 3.6
Dipyridamole 3.6
Dipyridamole 3.6
DMD 3.6
Coenzyme Q10 3.5
Berberine 3.5
FTA 3.5
Ribavirin 3.4
dipropyl 3.4
MK801 3.4
Catechol 3.4
Ubiquitin 3.4
manganese 3.3
Formal 3.3
4-chlorophenyl 3.3
4-chlorophenyl 3.3
TMA 3.2
TMA 3.2
Catechol 3.1
5-hydroxytryptophan 3.1
PLP 3.0
TAP 3.0
GABA 3.0
GABA 3.0
Clozapine 3.0
Valproic acid 3.0
GM2 3.0
Morphine 3.0
Flux 3.0
LPC 2.9
cyclopentyl 2.9
hydroxyindoleacetic acid 2.8
MCP 2.8
5-HT 2.8
Piper 2.7
Reserpine 2.7
Resveratrol 2.6
His 2.6
gamma-aminobutyric acid 2.6
NMDA 2.6
Nicotine 2.5
Letter 2.5
glutamate 2.5
SEE 2.4
noradrenaline 2.4
more...